#A new breakthrough in artificial design of proteins by the TEAM of the University of Science and Technology of China #In a paper launched this week by the top academic journal Nature, led by Professor Liu Haiyan and Associate Professor Chen Quan of the University of Science and Technology of China

In a paper launched this week by the top academic journal Nature, the research team led by Professor Liu Haiyan and Associate Professor Chen Quan of the University of Science and Technology of China showed a new route of protein design from scratch, especially for a major problem of artificial design of proteins - how to fully explore the structure space of protein backbones, providing a systematic solution.

It is reported that the team of Professor Liu Haiyan and Associate Professor Chen Quan has been committed to developing data-driven protein design methods for more than ten years in order to discover novel and "highly designable" main chain structures. After a long period of unremitting efforts, they broke through the limitation that only natural fragments can be used to stitch together to produce new backbone structures, and designed novel structures that are different from known natural proteins.

The press release of the University of Science and Technology of China pointed out that this work has achieved original innovation of key core technologies in the frontier science and technology field of protein design, laying a solid foundation for the design of functional proteins such as industrial enzymes, biomaterials, and biomedical proteins. Professor Liu Haiyan and Associate Professor Chen Quan of the Faculty of Life Sciences and Medicine are the corresponding authors of the paper, and doctoral students Huang Bin, Xu Yang and Hu Xiuhong are the co-first authors of the paper.

(Kenshi Bureau| 23)