When taking 12 kinds of medicines, "avoid smoking", and inhaling a mouthful will affect the efficacy of the drug

Regarding the "taboo" of taking medicine, people often pay more attention to diet and drinking, such as avoiding spicy food, cephalosporin can not be mixed with wine, etc., but ignoring the hidden harm of smoking.

In fact, the scope of contraindications for taking drugs also includes tobacco, which makes the drugs ineffective at the slightest and produces serious drug side effects.

Life Times (search for "LT0385" within WeChat to follow) interviews experts to tell you why you should avoid smoking when taking medication, and reminds you that you must not smoke when taking 12 drugs.

Experts interviewed

Wu Jiankun, chief pharmacist of the Department of Pharmacy of Beijing Hospital of Traditional Chinese Medicine

Jin Jian, deputy director of the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Why can't I smoke while taking the drug?

When the nicotine contained in cigarettes enters the body, it has an effect on the metabolic enzyme system in the liver. This process has two main effects:

Weakening or losing efficacy: Nicotine accelerates the rate at which the liver breaks down drugs, and smoking when taking the drug causes a decrease in the concentration of the drug in the blood, affecting the efficacy, especially within 30 minutes after taking the drug.

Increased adverse drug reactions: The above process will also slow down the process of drug metabolism, resulting in an increase in the effective concentration of the drug in the blood, greatly increasing the side effects of the drug.

Strictly speaking, smoking should not be taken while taking any medication. Studies have shown that smoking within half an hour before and after taking the drug will greatly reduce the active ingredient of the drug in the blood; smoking will also delay the emptying time of gastric contents and slow down the absorption of the drug.

It should be reminded that in order to ensure the efficacy and safety of medication, at least 3 points should be done:

Avoid smoking while taking the drug;

If you can't quit smoking for a short time, at least make sure not to smoke for half an hour before and after taking the drug;

If someone around you is taking medication during this time, you should also try to avoid smoking in front of them.

Smoking has a greater effect on 12 medicines

The alkaloids contained in the flue gas, such as nicotine and polycyclic aromatic hydrocarbon compounds, can affect the effect of many types of drugs such as the respiratory system, cardiovascular system, mental illness, acid suppression and stomach protection.

Specifically, smoking mainly adversely affects the following drugs.

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Antipyretic analgesics

Such as pain tablets. Smoking speeds up the metabolism of such drugs in the body, reducing their efficacy to even 1%. In addition, a large number of metabolites are difficult to quickly excrete from the body, which may lead to the accumulation of drug components and cause poisoning.

Sedative hypnotics

Such as alprazolam, diazepam and the like. Tobacco contains a large number of polycyclic aromatic hydrocarbon compounds, which can speed up the metabolism of such drugs; high concentrations of nicotine can stimulate the central nervous system, which has an excitatory effect on the central nervous system, thereby counteracting the sedative and sleep-aiding effects produced by drugs.

Vitamins

Such as vitamin C. A number of literatures have confirmed that vitamin C has the effect of enhancing human immunity, blocking carcinogens, and preventing excessive blood lipids, and after smokers take vitamin C, their blood drug concentrations are about 30% lower than those of non-smokers.

Diuretics

Such as furosemide. The nicotine in tobacco can reduce the blood concentration of furosemide and weaken its diuretic effect.

Asthma medications

Such as aminophylline. Patients with bronchial asthma often use aminophylline, if smoking at the same time, not only will reduce the efficacy, but also the drug is destroyed and excreted 3 times faster than non-smokers, so that its asthma effect is weakened and the maintenance time is shortened.

antidepressant

Such as amitriptyline and so on. Smoking can reduce the concentration of amitriptyline, chlorpromazine and other drugs in the blood, thereby reducing the efficacy of antidepressants.

Antacids

Such as cimetidine. Antacids are mainly used to treat peptic ulcers. Smoking constricts blood vessels and delays the emptying time of the stomach, so it slows down the absorption rate of the drug, reduces the efficacy and delays the healing of ulcers.

Hypoglycemic drugs

These include oral hypoglycemic drugs and insulin. Smoking can promote the release of catecholamines, constrict peripheral blood vessels, reduce the body's absorption of insulin, and release endogenous substances that antagonize insulin, further reducing the efficacy of insulin.

Therefore, smoking will not only interfere with the efficacy of insulin, but also reduce the efficacy of oral hypoglycemic drugs that promote insulin secretion.

Anticoagulants

Such as heparin, etc. The plasma half-life of heparin in the body of smokers is shorter than that of non-smokers, and their blood concentrations decline rapidly, thus affecting the efficacy of the drug.

Antianginal drugs

Such as propranolol and so on. Patients with angina with a history of smoking will have a significant decrease in blood concentration compared with non-smokers after taking propranololol, atenolol and other drugs, and the amount of drug excretion will increase.

contraceptive

Studies have found that women who smoke have a higher incidence of myocardial infarction after taking oral contraceptives than non-smokers.

aerosol

The endotracheal membrane of long-term smokers can form a layer of smoke tar, which affects the absorption of various types of aerosols in the trachea and reduces the efficacy of such drugs.

Chinese and Western medicines have their own scope of taboos

Doctors say that taking medicines should be avoided according to the nature of the specific drugs to distinguish the diet that should be avoided. The following guidelines are recommended:

Take Traditional Chinese Medicine

1. Avoid raw, cold, greasy, fishy and irritating foods

Raw and cold food is cold and easy to hurt yang qi; greasy food helps wet phlegm and is difficult to digest; fishy foods mostly contain certain hormones or heterogeneous proteins, which may induce allergic reactions; spicy foods are warm and easy to consume pneumatic fire.

2. Avoid foods that have adverse reactions to the disease

Liver disease should not drink alcohol, 90% to 95% of alcohol is metabolized in the liver, increasing the oxygen consumption capacity of the liver, prone to hypoxic necrosis;

Patients with asthma and allergic dermatitis should eat less fishy foods such as pork head, sheep, fish, shrimp, crabs and so on;

Diabetics should eat less of a diet high in sugars;

Patients with edema should not consume too much table salt;

People with weak spleen and stomach should avoid fried sticky, hard and indigestible foods;

Patients with poor sleep or insomnia should not drink tea, coffee, etc.

3. Contraindications to taking medicines recorded in ancient literature

Such as chinese medicine prescription licorice, huanglian, bellflower, ume taboo pork, honey avoid raw onions, etc., Chinese medicine should not pay attention to more, do not eat food contrary to the medicinal properties or affect the treatment during the medication.

Take Western medicine

Aspirin should not drink alcohol and juice, drinking alcohol can cause liver damage or aggravate the patient's condition, juice will aggravate aspirin irritation to the gastric mucosa;

When taking berberine, avoid drinking tea, because the tannin in the tea will decompose into tannic acid after entering the body, so that the alkaloids precipitate and reduce the efficacy;

Take ibuprofen to avoid drinking coffee and cola, so as not to cause stomach bleeding or gastric perforation;

When taking multi-enzyme tablets, avoid drinking hot water to avoid denaturation of the active proteins in them, weakening or losing their efficacy. ▲

Editor of this issue: Zhang Yu

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