For the treatment of asthma, which is better, budesonide formoterol or salmeterol fluticasone? 沙美特罗氟替卡松白天用好还是晚上用好？
Budesonide formoterol and salmeterol fluticasone are a combination of inhaled glucocorticoids and long-acting bronchodilators, which are controlling drugs for the treatment of bronchial asthma, budesonide and fluticasone are inhaled glucocorticoids, with local anti-inflammatory effects, can reduce the inflammatory response of the airways, improve asthma symptoms, prevent asthma attacks, and have fewer systemic adverse reactions with topical medication. Formoterol and salmeterol are long-acting bronchodilators, can relax bronchial smooth muscle, expand the bronchi, thereby relieving shortness of breath, wheezing symptoms, the use of a single action can be maintained for at least 12 hours, and has a certain anti-inflammatory effect, can effectively inhibit the release of allergic mediators, is an effective drug for the treatment of asthma.
Budesonide combined with formoterol, salmeterol combined with fluticasone, not only can control airway inflammation, but also relieve bronchospasm, play a synergistic anti-inflammatory and anti-asthmatic effect, can obtain a considerable or double dose of budesonide or fluticasone effect, reduce the adverse reactions of large doses of inhaled glucocorticoids, improve medication compliance, especially suitable for medium and severe asthma and long-term controlled treatment of COPD stability, through the correct medication can maintain a normal standard of living, Reduces acute attacks of asthma and COPD and irreversible damage to lung function, so that asthma and COPD are well controlled.
In terms of efficacy, compared with budesonide, fluticasone has better lipophilicity, stronger affinity with glucocorticoid receptors in the airway, anti-inflammatory effect is the strongest of all inhaled glucocorticoids, and the action time is long, local selectivity is good, and there are fewer systemic side effects. The advantage of budesonide is that it has a quick onset of action and is suitable for pregnant and lactating women. Formoterol is moderately hydrophilic and lipophilic, can be effective in 3 minutes, similar to salbutamol, can be used for first aid in acute attacks of bronchial asthma and COPD, salmeterol takes at least 30 minutes to take effect, not suitable for first aid, should carry salbutamol.
Clinical studies have found that for patients with bronchial asthma, when the treatment time is less than 6 months, budesonide formoterol and salmeterol fluticasone have little difference in the effect of asthma exacerbation, when the treatment time reaches 1 year, budesonide formoterol has a lower chance of exacerbation relative to salmeterol fluticasone, that is, budesonide formoterol has a better effect on asthma control.
Due to the nocturnal vagus nerve excitement, inducing bronchial contractions, so bronchial asthma often occurs or intensifies at night or in the early morning, which makes many friends think that the drug for the treatment of asthma should be used better at night, but this view is not the same, salmeterol fluticasone is a long-acting inhalation preparation, inhalation of a duration of action can reach 12 hours or more, so it is recommended to use it once every morning and evening, which can ensure that the time of action covers 24 hours throughout the day. Salmeterol fluticasone is effective at least 30 minutes after use, not suitable for acute asthma attacks, so once an asthma attack occurs at night, short-acting bronchodilators such as salbutamol sulfate should be used in time to quickly relieve asthma symptoms and save lives.
Tiotropinium is a long-acting bronchodilator, belongs to anticholine drugs, is currently clinically treated in the treatment of chronic obstructive pulmonary disease, chronic bronchitis and emphysema control drugs, suitable for maintenance therapy in the stable period, mainly through competitive binding with M1 and M3 choline receptors on the smooth muscle of the bronchi, to achieve the purpose of expanding bronchial smooth muscle, inhibiting respiratory glandular secretion, preventing colonization of bacterial infection, once a day medication, bronchodilation effect can last for 24 hours, good compliance, Long-term regular use can effectively alleviate breathing difficulties, improve lung function, reduce the frequency of acute exacerbations of COPD and related hospital stays, improve exercise tolerance, improve quality of life, and reduce the risk of death.
COPD is called chronic obstructive pulmonary disease, characterized by sustained airflow restriction, progressive development, slow onset, long course of disease, common cough, sputum production, dyspnea, chest tightness, asthma and other respiratory symptoms, initially patients only feel chest tightness and shortness of breath when going upstairs, climbing, with the progression of the disease, patients will feel wheezing when walking, and even rest, if not controlled in time, can develop into chronic respiratory failure and lung-derived heart disease, and eventually respiratory failure and death, COPD can not be cured, Controlling progressive exacerbations is key to treatment.
The goal of COPD treatment is to control symptoms for a long time, prevent the occurrence of future risks, improve the quality of life of patients, tiotropium bromide is a long-term control drug for the treatment of COPD, its role is to reduce the number of acute exacerbations of COPD, delay the progressive decline of lung function, improve the patient's exercise endurance, improve the quality of life, and long-term drug safety and tolerance is good, should be adhered to, even lifelong use. #Rumor Zero Plan # #守护银龄世界 #
