Eat statin, 5 types of people are prone to side effects! 5 solutions, commonly used by doctors
Original
2022-04-21 15:24
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Dr. Zhang Zhiying
With so many people who eat statin, who should pay special attention to preventing the occurrence of side effects? Let Dr. Zhang say that 5 types of people are relatively more likely to have adverse reactions (side effects), pay special attention!
In the real world, there are more and more people around us who eat statin. There are two main reasons behind this: first, more and more people with high blood lipids eat statins to reduce blood lipids; second, there are more and more patients with cardiovascular and cerebrovascular diseases, and eating statins can prevent and treat cardiovascular and cerebrovascular diseases. It is precisely because of these two reasons that there are now many people who eat statin so much that he has suddenly become the biggest "drug star". But who needs to pay more attention to the occurrence of adverse reactions? Dr. Zhang will tell you about 5 categories of people who need special attention.
First, 5 types of people eat statin, easy to have side effects
Today, Dr. Zhang told you that the following 5 types of people should pay special attention to preventing the side effects caused by statins, or the following 5 types of people are relatively more prone to statin-related side effects.
1, the elderly
When it comes to the concept of "old and old", many people do not understand. In fact, this concept refers to the elderly, generally referring to the elderly aged 75 or even over 80 years old. These elderly people's physical function is reduced, and it can even be said that they are relatively fragile, and eating statin at this time is indeed more important to pay attention to the occurrence of adverse reactions. The important mention here is that older women are relatively prone to statin side effects, and special attention should be paid to them.
2. Small weight and weak body
In the real world, for some people who are small and frail, if they decide to use statin lipid-lowering drugs, pay special attention to regularly reviewing related adverse reactions. Because these people are relatively prone to adverse reactions, which is what everyone calls side effects.
3. Combined multi-system disease
For many people who eat statins, there may be multiple systemic diseases, especially people with serious chronic diseases such as diabetes and renal insufficiency, the chance of side effects is relatively greater, and special attention should be paid to monitoring the occurrence of adverse reactions.
4. People who drink alcohol
For many people who are eating statins, they do not quit drinking, but stick to the habit of drinking. This type of person has a greater chance of developing statin-related side effects, and special attention should be paid to it. Because both stigmatin and alcohol are metabolized by the liver, people who drink alcohol are more likely to have side effects when they eat statin.
5. People who are eating certain foods and medications
When it comes to foods and drugs that tatin may react to, it really needs to be explained to everyone in detail:
When it comes to foods that may affect statin, Dr. Zhang would like to point out that grapefruit is rich in furancoumarin, which has the highest content of grapefruit, followed by grapefruit, oranges, oranges, lemons and other similar foods. Eating too much of this type of food may affect the metabolism of atorvastatin, simvastatin, and lovastatin (lipid profile), which in turn leads to a high incidence of side effects. Because these 3 types of statins are all metabolized by the liver cytochrome enzyme P450 3A4, and foods rich in furan coumarin will seriously affect this enzyme system, which in turn will cause side effects of statin lipid lowering drugs. Therefore, if you eat these 3 types of statins, you should pay attention to eating less fruits such as grapefruit.
When it comes to drugs that affect statin, the guidelines are of the following categories: macrolide antibiotics (azithromycin, erythromycin, clarithromycin, roethromycin), nefazodone, pyrrole antifungals (ketoconazole, miconazole, fluconazole, itraconazole, and voriconazole), cyclosporine, verapamil, amiodarone, protease inhibitors (ritonavir, nefenavir). These drugs may affect the cytochromase P450 system, increasing the chance of adverse reactions in statins.
Second, there are side effects, what should be done?
What should we do about some people who have already discovered statin side effects? My advice is to seek medical attention promptly and make adjustments under the guidance of a doctor. However, even if the doctor takes the lead in the adjustment, we can get a rough idea of the treatment options that may be available:
1. Stop statin
For some patients who have serious side effects, whether it is severe liver function damage or muscle damage, statin lipid lowering drugs can be discontinued under the guidance of a doctor. Generally speaking, the side effects of statin are reversible and gradually disappear with the prolongation of the discontinuation time.
2. Switch to another statin
Clinically, for cases where statins bring obvious side effects, they can also be switched to statin lipid-lowering drugs with relatively small side effects under the guidance of professional doctors.
3. Reduce the dose of statin use, combined with other lipid-lowering drugs
In cases where statins have side effects, another treatment option is to reduce the dose of statin used, such as halving the dose, in combination with other lipid-lowering drugs. This is also a common treatment scenario.
4. Interval medication
There are a small number of patients who have side effects by taking statins, and the problem of side effects can also be solved by the method of interval medication. For example, some statins with a longer half-life can be taken every other day to make blood lipids meet the standard and reduce the occurrence of side effects. However, this method of taking medicine every other day is relatively rare and is not routinely recommended.
5. Remove precipitating factors
As we told you earlier, some diets and drugs are precipitating factors that increase the occurrence of statin side effects, and we must pay attention to these precipitating factors that can be removed. If there are these precipitating factors, we must pay attention to removing them in time, so that the side effects related to his estin occur less.
The above is Dr. Zhang's answer to these questions, I hope this article can help more people, everyone feels good can also be forwarded to friends and relatives around. If you think it's good, you can forward it to your friends and relatives in time.