I heard that "statin" drugs raise blood sugar and increase the risk of new diabetes, and some people are worried, don't have high blood pressure and coronary heart disease that are not cured, but they have diabetes.
Therefore, he did not dare to take the drug.
To say that "statins raise blood sugar and increase the risk of new diabetes" is not an empty phrase.
Studies in recent years have indeed found that statins raise blood sugar and increase the risk of new-onset diabetes.
Moreover, this adverse reaction belongs to the "class effect" of statins, that is, the adverse reactions of different statins and such drugs.
However, things are not so simple.
Studies of statins raising blood sugar and increasing the risk of new-onset diabetes have found several findings.
* Onset of the disease.
The study found that statin treatment of 255 patients for 4 years increased the number of new diabetes patients by 1 case, and the risk was mainly in the elderly. So the incidence is still very low and age-related.
* Causes, i.e. why do statins raise blood sugar and increase the incidence of diabetes?
Studies have suggested that statin drugs may be related to the fact that in the process of lowering cholesterol, it affects the release of insulin and reduces cell uptake of glucose.
But here's the problem. Diabetes in cardiovascular patients and "three high" patients is related to their own conditions. Many patients are themselves at high risk for diabetes. Therefore, the study also found that in patients with multiple diabetes risk factors, in patients with metabolic syndrome, obesity, and elevated blood sugar, the risk of developing diabetes after taking statins increased.
Therefore, some patients who develop diabetes after taking statins cannot be simply attributed to taking drugs, but are related to their own risk factors.
* The risk of developing diabetes is related to the dose of statin drugs.
Studies have found that taking large doses of statins will significantly increase the incidence of diabetes. For example, atorvastatin 10 mg per day will increase the risk of diabetes by 4%, if you eat 80 mg per day, it will increase the risk of diabetes to 15%; rosuvastatin 10 mg per day, increase the risk of diabetes by 11%, if you eat 20 mg per day, it will increase the risk of diabetes by 25%. These large doses are beyond the daily doses taken by mainlanders.
* The risk of developing diabetes and the variety of tatines are also related.
Studies have found that pravastatin and pitvastatin cause blood sugar increases and increase the risk of new diabetes.
* Most importantly, the benefits of statins for cardiovascular disease far outweigh the risks compared to the increased risk of elevated blood sugar and new diabetes.
That is, the benefits of taking statins clearly outweigh the disadvantages.
Statistical results show that adding 1 new diabetes to every 255 cases treated can avoid 5.4 deaths from coronary heart disease or non-fatal myocardial infarction, and also reduce about the same number of strokes and coronary artery resvascularization (stenting, bypass). In this way, the ratio of benefit to risk is 9:1, and the benefit is far greater than the risk.
Although taking statins increases the risk of new diabetes, it is beneficial to prevent and treat cardiovascular disease and should be taken.
Diabetics are at high risk of cardiovascular disease, and diabetes is a critical disease of coronary heart disease. Diabetics should lower blood lipids, anti-atherosclerosis, but also to eat statin.
Moreover, studies have found that diabetics taking statin drugs also have the effect of improving atherosclerosis and protecting the heart muscle. Therefore, statins are also commonly used drugs in people with diabetes.
To reduce and avoid the adverse effects of statin drugs raising blood sugar, we can do this.
* Improve lifestyle and reduce risk factors for diabetes.
For example, controlling diet, reducing weight, increasing exercise, etc.
* Avoid taking statin in large doses.
For cholesterol-lowering therapy in the mainland, it advocates moderate-intensity statins, which is equivalent to the conventional daily dose of statin drugs. If a single statin is not up to standard, you can also take "mebe" drugs that inhibit the absorption of intestinal cholesterol, and you can fold mebrabe and haibo mebra. No more, there are cholesterol-lowering injections, such as iloclimumab, alisidimab, the effect of cholesterol lowering is very strong (coronary heart patients, cholesterol-lowering treatment standard "four steps").
* Statin drugs with less effect on blood glucose can be used.
In clinical studies, it was found that there are few adverse reactions of pitvastatin and pravastatin to raise blood sugar, and can be selected according to the patient's situation.
* Pay attention to monitoring.
For patients with cardiovascular disease, for patients at high risk of cardiovascular disease, such as patients with hypertension, it is necessary to screen for diabetes. In the process of taking statins, it is also necessary to pay attention to monitoring blood sugar and glycosylated hemoglobin. Because these patients are prone to diabetes mellitus and can be developed sequentially. Pay attention to monitoring during treatment, you can detect early and treat early.