For friends with cardiovascular and cerebrovascular diseases, the most important drugs are aspirin and statin drugs.
Everyone is familiar with aspirin, but it is relatively unfamiliar with statin drugs, and there are many questions about statin drugs, which we summarize one by one today.
First, statin drugs have 4 major effects
Many people are not his drugs that lower blood lipids? To be more precise, isn't it a cholesterol-lowering drug?
If you know statins in this way, it is too small to look at statin drugs, and the effect of statin drugs is far more than that simple.
1. Statin drugs are drugs that adjust blood lipids
Statin is mainly to reduce the scurebemia of LDL cholesterol, because after the increase of serupine, more vascular garbage will be generated, so he is reducing the role of vascular garbage by lowering the scurebemia of LDL cholesterol.
Statin drugs can also raise high-density lipoprotein cholesterol, which is a good blood lipid, because after the good blood lipids are elevated, it will clean up too much blood vessel garbage, so he tingtin drugs reduce blood vessel garbage by raising high-density lipoprotein cholesterol, which is a good blood lipid.
Statin drugs also have a mild reduction of triglycerides, which have the effect of reducing blood lipids, and long-term elevation of triglycerides will also aggravate atherosclerosis, and statins can reduce mild triglyceride elevations, thereby preventing atherosclerosis from worsening.
So histin is not only a lipid-lowering drug, but a lipid-adjusting drug that lowers bad blood lipids and raises good blood lipids. The main purpose of lipid regulation is also to protect blood vessels.
2. Anti-inflammatory, protect vascular endothelium
One of the main reasons for the atherosclerosis of arterial blood vessels, that is, the growth of many plaques in the inner wall of blood vessels, is that the endothelium of blood vessels is inflamed, that is, the inflammatory response. Statin drugs are able to resist inflammation, inhibit the inflammatory response, and thus reduce the degree of delaying atherosclerosis. That is what everyone calls the protection of blood vessels.
3. Clean up apoptotic cells in blood vessels
Arterial angiogenesis plaques, in addition to being associated with elevated LDL cholesterol, are not only related to inflammatory responses. It is also related to the fact that apoptosis cells in the blood are not easily metabolized. Statin drugs can clean up the apoptosis cells in the blood vessels, thereby delaying atherosclerosis and protecting the blood vessels.
4. Stabilize the plaque, prevent the plaque from rupturing, prevent blood clots, and then prevent myocardial infarction and cerebral infarction
The reason why we have myocardial infarction or cerebral infarction is because of thrombosis. Thrombosis is formed after the rupture of an unstable plaque within a blood vessel. Therefore, it is especially important to ask about plaques and prevent plaque rupture.
Statins stabilize plaques and reverse unstable plaques into stable plaques. Plaque is stable, it is not easy to rupture, it is not easy to form a thrombus, without thrombosis, there will be no myocardial infarction and no cerebral infarction, so hetin is the basic drug to prevent thrombosis, prevent myocardial infarction and cerebral infarction.
Although statin has so many effects, everyone is still unfamiliar with statin, especially related to the following 4 issues:
Second, the attention of statin drugs 4 items:
1. Does statin have to be eaten at night?
not necessarily!
First- and second-generation statins, such as simvastatin, lovastatin, pravastatin, fluvastatin are short-acting statins, the duration of action is short, so it must be taken at night.
And the third generation of statin: rosuvastatin, pitvastatin, atorvastatin, all belong to the long-acting statin, eating during the day and eating the same effect at night.
2. What can't I eat with statin?
Do not drink alcohol while taking statins. so as not to increase the burden on the liver!
During the period of taking simvastatin, lovastatin, and atorvastatin, do not eat grapefruit as much as possible, and do not take anti-inflammatory drugs such as erythromycin and clarithromycin. so as not to increase the side effects of the drug.
3. Can I eat it every other day?
Eat statin as much as possible once a day, not every other day.
As for whether you can eat half a tablet of statin, it varies from person to person, if you eat half a amount of statin, LDL can also meet the standard, indicating that you can do half a amount. If you eat a full amount of statin, the low density is not up to standard, then you can not increase the amount, but to combine with the folding wheat cloth or lipid-lowering needles to lower fat.
4. When is the review?
Taking statin everyone is most concerned about drug side effects, in addition to doing the above 3 points, can reduce drug side effects, remember that you must be in the 1st month, 3 months, 6 months, 12 months, and then every year should be regularly reviewed.
Third, take statin to do 4 re-examinations:
The main thing is the following 4 blood tests
1. 4 items of blood lipids:
Total cholesterol, low density, high density, triglycerides, mainly depends on whether low-density lipoprotein has reached the standard. There are 3 indicators of LDL cholesterol, and the ideal level of different populations is different, which is lower than 3.4mmol/L, less than 2.6mmol/L, and less than 1.8mmol/L. According to your own specific situation, reach the target level.
2. Liver function:
Mainly look at transaminases, because taking statins, there will be a small number of people transaminases elevated, if the transaminases are more than 3 times higher, you need to stop the drug, so the re-examination of liver function mainly to see if there are side effects of the tampin.
3. Creatine kinase:
Statin drugs can theoretically cause muscle damage, manifested by muscle pain, soreness, fatigue, etc., the most serious may lead to muscle lysis, kidney failure. Therefore, during the period of taking statin, it is necessary to recheck the creatine kinase, mainly to see if the humanin has caused muscle damage.
4. Blood glucose:
Mainly whether the statin has caused blood sugar to rise and cause diabetes. If an elevated blood sugar is detected, a visit to the endocrinologist is required rather than taking the liberty of discontinuing the statin without permission.
Of course, if it is a simple hypolipidemic drug, you can replace other lipid-lowering drugs, but if it is to protect blood vessels, then it is not recommended to stop the drug casually.
Today, he Tantine drugs, the problems that everyone is most concerned about, have been summarized, please collect and read.