In China today, more and more people take statin lipid-lowering drugs in their daily lives. So much so that statin is now the biggest "drug star", and its aura even surpasses the famous aspirin. The reason behind this is the increase in two types of people: on the one hand, there are more and more patients with hyperlipidemia, and on the other hand, there are more and more patients with cardiovascular and cerebrovascular diseases. Both types of people need to reduce blood lipids by taking statin lipid-lowering drugs, thereby reducing the incidence of cardiovascular and cerebrovascular diseases.
Can eating statins cause diabetes? Listen to Dr. Zhang's explanation
However, in the process of taking statin lipid-lowering drugs, many people have heard from different ways that eating statins may lead to elevated blood sugar and the occurrence of diabetes. Therefore, many people are still very worried that statin will raise blood sugar and lead to diabetes problems. How to put this problem in perspective. Today, Dr. Zhang Zhiying will explain this problem to you carefully.
First, the origin of statin lipid-lowering drugs
The widespread use of statin lipid-lowering drugs, strictly speaking, is still after 2000, especially in the first decade of the new millennium, many people began to eat such drugs because cardiovascular and cerebrovascular diseases need to lower blood lipids. However, after people have eaten for a while, some people develop diabetes-related problems. Therefore, clinicians who are slowly more careful will feel that some patients have high blood sugar because of long-term eating statin lipid-lowering drugs. This received recognition from the authoritative medical community in 2012.
In 2012, the U.S. FDA (Food and Drug Administration) issued a statement on its official website that his lipid-lowering drugs may trigger the possibility of elevated blood sugar and new-onset diabetes.
In the same year, the European Medicines Agency's Pharmacovigilance Task Force required that all statin-containing instructions for listing in Europe must be added as a warning that statins may trigger diabetes.
In 2013, China's CFDA (Food and Drug Administration) also required all statin lipid-lowering drugs to add to their labels an indication of adverse reactions that statins may cause elevated blood sugar. (The picture below is the expression of this part in the statin specification listed in China)
These are these changes, and for a time statin lipid-lowering drugs will cause diabetes, and many people even refuse to take statin lipid-lowering drugs for fear of developing diabetes.
In China, this is a statin fat-lowering drug instruction manual
Second, the research data of statin lipid-lowering drugs to raise blood sugar
Long-term consumption of statin lipid-lowering drugs raises blood sugar, and there have been different conclusions in different studies. A comprehensive analysis of 13 studies before 2014 showed that more than 90,000 patients using statins were comprehensively analyzed, and the results found that the 5 commonly used statins, namely atorvastatin, rosuvastatin, simvastatin, pravastatin, and lovastatin, all had adverse reactions to elevated blood sugar, especially leading to new-onset diabetes, and the incidence was 9%.
In 2011, a related meta-study published in jama, the authoritative medical journal "American Annals of Internal Medicine", comprehensively analyzed more than 30,000 patients who ate statin without diabetes, and finally found that high-intensity statin treatment led to a 12% increase in the probability of new diabetes.
Many subsequent medical studies have refined the screening of the subjects of the study, and found that those who are elderly, obese, prediabetes, lack of physical exercise, and high-sugar diets are more likely to develop diabetes by taking statin lipid-lowering drugs.
American Annals of Internal Medicine, JAMA Magazine
Why do statin lipid-lowering drugs raise blood sugar?
1. Statin causes mitochondrial dysfunction of muscle cells, fat cells, β islet cells, etc., resulting in insulin secretion disorders, which in turn leads to insulin resistance;
2. Cause the sensitivity of fat cells to insulin to decrease, which in turn leads to insulin resistance;
3. Cause muscle damage and decrease muscle mass, reduce muscle activity, thereby reducing energy consumption, and also trigger insulin resistance.
Fasting blood sugar is high
Fourth, how to objectively and fairly view the problem of statin raising blood sugar?
After reading the above content, many people who should have eaten statins may not be willing to take statin lipid-lowering drugs anymore. So, how should we look at this? Dr. Zhang's advice is: you should eat or eat. Why?
Because at this stage, more in-depth medical research has found that the ratio of cardiovascular benefits that may be brought about by taking statin lipid-lowering drugs to the risk of new diabetes is 9:1. In layman's terms, that is, eating statin brings 9 benefits, while the risk is only 1 part, it can be said that the benefits are far greater than the risks. Seeing this, I guess everyone can see it clearly. In fact, for patients with hyperlipidemia and cardiovascular and cerebrovascular diseases, as long as there are indications for taking statins and there are no contraindications, the use of the situation can still be used under the guidance of professional doctors. Just because you have heard about the adverse effects of statin lipid-lowering drugs, you should not delay regular treatment because of fear. That way, your losses could be even greater.
9 points of return, 1 point of risk
In fact, at this stage, most of the statin doses Chinese eat are small and medium doses, and the risk of side effects such as blood sugar rise brought by this small and medium dose of statin is even smaller, and there is no need for everyone to be grass and trees. Especially those who have a high risk of cardiovascular and cerebrovascular diseases, they should take statins or take them under the guidance of a doctor.
V. How to deal with the adverse reactions of statins that raise blood sugar?
1. Before taking statin lipid-lowering drugs, pay attention to screening your own blood glucose, such as pre-meal blood glucose, postprandial 2 hours of blood glucose and glycosylated hemoglobin, for those who have elevated pre-diabetic states, pay attention to choosing statin lipid-lowering drugs that have a relatively small impact on blood sugar.
2. In the process of eating statin lipid-lowering drugs, pay attention to improving lifestyle, pay attention to scientific diet and moderate physical exercise, so as to further reduce the incidence of diabetes.
3. For patients who have already developed diabetes, professional hypoglycemic treatment can be carried out under the guidance of professional doctors, and blood sugar can be controlled as soon as possible to reduce its damage to cardiovascular and cerebrovascular diseases.
The above is Dr. Zhang Zhiying's answer to the question that statin will raise blood sugar, I hope that everyone can help after reading it. If you think this article is not bad, you can also forward it to friends and relatives who are eating statin, so that more people can benefit.