We are about to have more "weapons" that reduce blood lipids, and no matter how difficult it is to reduce blood lipids, there is hope! At the beginning of the new year, I would like to dedicate this article to those who have high blood lipids.
High blood lipids have become an eternal pain in the hearts of modern people. The good days are too long, but the longer the good days pass, more and more people now have elevated blood lipids. So many people with high blood lipids, part of the reason is because of our unhealthy lifestyle, and part of the reason is because our medical conditions are better, and the high blood lipids that were not found before are now found through examination. However, with so many patients with high blood lipids, the existing treatment methods can only make some of them better, and many people cannot be cured. So, what should these people do? Is there a better treatment for humans?
Speaking of which, Dr. Zhang would like to give you some good news. On january 20, 2022, Professor Lale, former president of the European Atherosclerosis Society, and Dr. Peter, the founder of the theory of atherosclerotic inflammation and Dr. Peter of Harvard Medical School in the United States, jointly published a paper in the well-known "European Heart Journal" that lipid-lowering therapy may usher in a new era, and we may have more "new weapons" to reduce blood lipids.
In the past 20 years, human lipid-lowering drugs have undergone great changes
Speaking of which, it has to be said that we humans have experienced several lipid-lowering stages.
The first stage is only statin stage, this stage is not far away, about twenty years ago in this period of time, that is, 1999-2014 this time, people control blood lipids only statins a class of drugs, this time people blood lipid control is not good, so many people even if the stent, atherosclerotic plaque will still progress, myocardial infarction, cerebral infarction and other cardiovascular and cerebrovascular diseases are difficult to control.
The second stage, that is, about 2014-2018, human medicine in addition to statins, began to have other lipid-lowering drugs, such as ezetimibu, a drug that inhibits cholesterol absorption, which can cooperate with statin lipid-lowering drugs to control blood lipids better. At this time, we began the era of hypolipidemic lipids of statin + ezez-mebe.
The third stage is that in the past 3 years, we have a better treatment to control blood lipids, such as PCSK9 inhibitors, which is often called "lipid-lowering vaccines" by the people. In fact, this drug is not a vaccine drug, it is just a lipid-lowering drug administered by injection. This drug lowers blood lipids more intensely, and for many patients who do not have obvious effects on statins or have large side effects, it is relatively better to use PCSK9 inhibitors.
Speaking of which, we also want to bring you some new good news, that is, two new lipid-lowering drugs that are doing Phase 3 clinical trials in Europe, which are "antisense oligonucleotide preparations" and "small interference RNA preparations". These two new lipid-lowering drugs may have a better lipid-lowering effect, and even have a good reducing effect on lipoprotein (a), a blood lipid index that humans have not been able to achieve. At the same time, the good news to report to you is that in the near future, lipid-lowering therapy may usher in a new era of targeted therapy, which is also very gratifying.
At the end of this article, Dr. Zhang still wants to tell you that for this stage, the friends in front of the mobile phone are most contacted by oral lipid-lowering drugs represented by statin and ezezémaebe, and many drugs have not yet entered our lives. During this period of time, for those patients with cardiovascular and cerebrovascular diseases or hyperlipidemia, we must try to control blood lipids under the guidance of doctors, minimize the harm of high blood lipids to our bodies, and wait for better drugs to enter our daily lives, I believe that time will not be too far.