Aspirin and statin drugs are the basis for the treatment of cardiovascular and cerebrovascular diseases!
So when exactly when will these two drugs be effective?
There is also a question that everyone is most concerned about, that is, when to take the least side effects?
1. Aspirin
1, what is the role
Small-dose aspirin, that is, about 100mg of aspirin, is the basic drug for the treatment of cardiovascular and cerebrovascular diseases. Because aspirin can resist platelet aggregation, it plays a role in preventing blood clots.
Therefore, for patients with clear coronary heart disease, angina, myocardial infarction, cerebral infarction (atherosclerotic type), cardiac stents, cardiac bypass, etc., long-term aspirin is needed to prevent thrombosis.
2. Aspirin is divided into two types according to the dosage form
Aspirin enteric-coated tablets or enteric-coated aspirin, then this aspirin is generally recommended to be taken on an empty stomach.
Enteric-coated aspirin has a thin film on the surface to ensure that the drug passes smoothly through the stomach, reaches the intestine, and begins to be absorbed. If you take enteric-coated aspirin after eating, then aspirin enteric-coated tablets will be blocked by food in the stomach and will not easily reach the intestine. The longer you spend in the stomach, the greater the stimulation of aspirin to the stomach and the easier it is to cause stomach damage. If you eat enteric-coated aspirin on an empty stomach, then the pill will pass through the stomach smoothly and reach the intestine, which will reduce the damage of aspirin to the stomach.
Therefore, enteric-coated aspirin is generally recommended to be taken on an empty stomach.
The other is the common dosage form of aspirin, which is generally recommended to be taken after a meal. This is also the truth that everyone understands, if this kind of aspirin is taken on an empty stomach, it will quickly decompose in the stomach, then it is easy to cause stomach damage. So take it after a meal, there is food in the stomach, reduce the stimulation of the drug on the stomach.
In short, remember one sentence: enteric-coated aspirin, taken on an empty stomach; regular aspirin, taken after a meal.
3. Do you take it in the morning or at night?
Regarding whether aspirin is taken on an empty stomach in the morning or on an empty stomach before going to bed at night, it is currently said that the public is reasonable, and there are two theories, each of which has a certain truth. The guidelines do not give us a clear time point for taking it.
So according to personal habits, there is no requirement sooner or later.
4. Reduce side effects
Remember that different dosage forms are taken differently, and remember not to drink alcohol while taking aspirin to avoid increasing the risk of bleeding. At the same time, during the period of taking aspirin, pay attention to the color of the stool, and if it turns black, go to the doctor in time. And do regular review to avoid failing to find drug side effects.
2. Statin drugs
Aspirin is actually a drug, which is aspirin. Statin is a large class of drugs, including simvastatin, lovastatin, pravastatin, fluvastatin, atorvastatin, rosuvastatin, pitvastatin and so on.
Statins can lower the bad lipid of LDL cholesterol and can increase the good lipid of HDL cholesterol. At the same time, statin drugs can be anti-inflammatory, protect the vascular endothelium; remove vascular endothelial apoptotic cells; stabilize vascular plaques, prevent plaque rupture, and prevent blood clots.
It is suitable for patients with clear coronary heart disease, angina, myocardial infarction, cerebral infarction (atherosclerotic type), cardiac stents, cardiac bypass, etc., and is the golden partner of aspirin.
2. Is statin eaten during the day or at night?
There is a saying that statin must be eaten at night, and this statement is true. As long as everyone remembers this sentence, it is all statin to eat before going to bed, it is certainly not wrong.
This is because statins lower cholesterol by inhibiting the secretion of enzymes by the liver. But the liver secretes this enzyme in a characteristic, that is, they only come out to work at night. So if you take statin drugs during the day, statin works, but the liver does not secrete this enzyme during the day, and statin does not have a lipid-lowering effect. When the liver secretes this enzyme at night, but the statin fails, the result is to eat statin during the day, which is equivalent to eating it for free.
So only take statin at night, just in time for the liver to secrete this enzyme, statin also just inhibit the liver does not allow the liver to secrete more enzymes, and then will not produce more cholesterol, play a lipid-lowering effect.
But not all statins have to be taken at night.
Statin is divided into short-acting statins, there are also long-acting statins, short-acting is a short period of action, so it must be taken at night to be effective, such as simvastatin, lovastatin, pravastatin, fluvastatin.
But the third generation of statin belongs to the long-acting statin, atovastatin, rosuvastatin, pitvastatin, then you can take it during the day, because even if you take it during the day, it can still play a role in inhibiting the liver at night, and can also play the same lipid-lowering effect. So the third generation of statin is taken day and night with the same effect.
3. Reduce side effects
During the period of taking statin, do not drink alcohol, so as not to increase the burden on the liver; try not to eat grapefruit; at the same time pay attention to the review, the 1st, 3rd, 6th, 12th months need to be drawn for blood tests, and blood tests should be drawn every year after that: liver function, creatine kinase, blood sugar, blood lipids four items.
On the one hand, it is to reduce side effects, on the other hand, small problems are found early and solved as soon as possible, so as not to cause big problems.
In short, for ischemic cardiovascular and cerebrovascular diseases, aspirin and statin are a golden partner. However, be sure to choose the right time to take it, so as not to have a bad effect, so as not to aggravate the risk of side effects.