Metformin and Oslita can both lose weight, which effect is good?
Two days ago, Dr. Zhang's mother chatted with Dr. Zhang and said that she never expected that obesity has now become a big health problem. If you think about it, the incidence of obesity among mainland adults is very high, and it has caused a series of complications that pose a huge threat to people's health. Weight loss has become a mainstream topic, and now many friends are using educational drugs to lose weight.
There are many common types of weight loss medications that are taken with metformin and orlistat. Compared with these two drugs, which one has a better effect on weight loss?
A recent study in a domestic journal elaborated on this issue. This article is a study of polycystic ovary syndrome.
Polycystic ovary syndrome is the most common endocrine disease in women of childbearing age, obesity occurs in patients with polycystic ovary syndrome as high as 30% to 70%, the incidence of type 2 diabetes, diseased hypertension, cardiovascular disease has increased significantly, and weight loss plays a key role in the treatment of obese and overweight PCOS patients.
Many experts recommend metformin and orlistat as weight loss drugs. Metformin is a more familiar drug for the treatment of type 2 diabetes, and its principle of weight loss is to reduce appetite and inhibit gastrointestinal peristalsis, so as to achieve the purpose of weight loss. The main role of orlistat is to inhibit the absorption of lipids by the intestine. Which of these two drugs works better?
This study found that both metformin and orlistat can significantly reduce weight, BMI, and hip circumference in people with overweight or obese POLYOS.
Orolistat is more significant in weight loss than metformin. The rate of improvement for BMI was similar.
In terms of glucose metabolism, orlistat improves insulin resistance in obese patients associated with the course of medication, and after 3 to 6 months, fasting blood glucose is found, and insulin levels will decrease significantly.
Suggests that orlistat can improve insulin resistance in overweight and obese patients, both in short-term and slightly longer courses of treatment. However, it cannot be used alone as a hypoglycemic drug.
In terms of lipid control, the decrease in cholesterol and triglyceride levels after orlistat treatment is more pronounced than metformin.
Therefore, orlistat has an advantage in improving metabolism in obese and overweight patients, which is related to the mechanism by which orlistat inhibits the absorption of lipids in the intestine.
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