Mr. Wang is 45 years old and has a son
After my son went to high school boarding
The couple is ready to have a second child
Considering the advanced age, Mr. and Mrs. Wang went
Guangdong Provincial Reproductive Hospital conducts eugenic consultation
Preconception tests were carried out separately
But that's the check
Pushed their marriage to the cusp
Mr. Wang was found to have no sperm in his semen
Mr. Wang was surprised
Since I am an azoospermia
So where did the son come from?
That moment
Mr. Wang suspected that his wife was having an affair
The wife was furious
Proposed to do a paternity test
After an anxious wait
Mr. Wang finally got the appraisal opinion
The results showed that the child was Mr. Wang's biological son
Mr. Wang was very happy to get the results
But there are still doubts in my mind:
"Why did I have sperm in my previous semen,
But now there are no sperm in the semen"?
Hospital eugenic genetics experts recommend
Mr. Wang did further examinations
The first is to check whether it is due to genital tract infection
Causing the vas deferens to block and the sperm to fail;
The second is to see if there is a genetic defect,
Leads to a decrease in spermatogenesis function.
In the end, Mr. Wang was diagnosed
Y chromosome microdelete
(Report prompts: AZFc region is missing)
What is a Y chromosome microdeletion?
Zheng Lixin, chief expert of eugenic genetics at Guangdong Reproductive Hospital, introduced that everyone has 46 chromosomes, of which the Y chromosome is unique to men and plays a vital role in the process of male spermatogenesis.
There are azoospermia factor (AZF) regions that affect spermatogenesis on the long arm of the Y chromosome, including AZFa, AZFb, and AZFc, and the deletion of these regions may lead to oligospermia, weak sperm, and azoospermia in men. Among them, the loss of the AZFc region is the most common, accounting for about 80%, which is manifested as oligospermia, weak sperm, and azoospermia, and can present progressive spermatogenesis dysfunction.
"Mr. Wang is a patient with the loss of the AZFc area, the semen quality decreases progressively with age, and when he is young, he may manifest as a small number of weak sperm, and in certain circumstances, there is a probability that the woman will be conceived normally."
Zheng Lixin said that the micro-deletion of Y chromosomes in such patients will often expand during the transmission process, resulting in the occurrence of offspring infertility, it is recommended that Mr. Wang's son be examined for semen after the age of 18, if there are sperm in semen, it is recommended to apply for sperm cryopreservation and early fertility, so as to avoid the phenomenon of sperm production disorders with age.
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Correspondents: Gu Heng, Zhang Jing, Cai Jiaqi