Inter-arm inversion of the Y chromosome requires a third-generation IVF pregnancy. Chromosome interarm inversion will lead to a series of adverse pregnancy outcomes such as infertility, miscarriage, stillbirth, deformity, etc., and the third generation of IVF uses PGS/PGD technology to test the number and structure of its chromosomes before implanting the embryo into the mother's uterus, screen out healthy embryos of normal chromosomes for transplantation, fundamentally eliminate the adverse effects of chromosomal interarm inversion on fertility, and ensure healthy fertility.
The inversion between the arms of the chromosome cannot be adjusted by drugs, so the best and most effective way for patients with abnormalities in the chromosome is to assist in pregnancy through the third generation of IVF technology, screen out the abnormal embryos in the chromosomes, transfer normal embryos, and reduce the probability of the occurrence of risk situations such as miscarriage, stillbirth or development into a congenitally malformed fetus:
1. Avoid miscarriage and fetal cessation. The phenomenon of miscarriage in patients with chromosomal interarm inversion occurs in the first trimester, and the third generation of test tubes greatly reduces the risk of fetal chromosomal abnormalities through PGD and PGS technology, and avoids the occurrence of fetal abortation from the root;
2. Avoid embryonic growth retardation. Before embryo transfer, three generations of test tubes can screen out abnormal structural changes and abnormal division of abnormal chromosomes that appear in inverted positions, avoiding abnormal fetal development due to abnormal chromosomal abnormalities;
3. Avoid congenital malformations of the fetus. Children born with chromosome interarm inversion may have congenital malformations such as heart, kidney and scalp defects, and in severe cases, it will affect intelligence, while the third generation of test tubes screens out chromosomally abnormal embryos to avoid fetal malformations caused by chromosomal abnormalities.
In summary, the third generation of IVF technology from the perspective of biological genetics, preimplantation genetic diagnosis, selection of the best quality embryos for transfer, to a large extent to reduce the incidence of bad pregnancy, birth defects, for future parents with genetic diseases to provide opportunities to have healthy children, to achieve more infertile families of fertility dreams.
Chromosomes are the genetic material of the organism, and there are tens of thousands of genes distributed on the chromosomes, which determine the characteristics and normal physiological processes of the organism, and have a very significant impact on eugenics. The third generation of IVF through PGD and PGS technology, so that chromosomal abnormalities patients see the hope of giving birth to healthy children, help many infertile couples successfully have their own baby:
PGD technology. PGD is primarily used to check whether embryos carry genes that are genetically defective. After the sperm egg combines to form a fertilized egg and develops into an embryo, genetic testing is performed before it is implanted in the uterus. At present, preimplantation genetic diagnosis can diagnose some diseases caused by single gene defects, such as thalassemia and other diseases;
PGS technology. PGS refers to the detection of the number of chromosomes and structural abnormalities of early embryos before IVF embryo transfer, mainly by detecting the 23 pairs of chromosomal structure and number of embryos, and analyzing whether the embryos have genetic material abnormalities by comparison.
The third-generation test tube technology is more mature and advanced than the first and second generation test tubes, and the screening accuracy rate for abnormal problems such as chromosomal deletion, repetition, translocation, and inversion can reach more than 99.9%, so as to avoid chromosomal abnormalities parents passing on genetic diseases to the next generation, and it is also particularly suitable for some couples who are elderly, recurrent miscarriage, women's ovarian failure, and difficulty ovulation.