What about chromosomal-induced fetal cessation? Hello doctors at Antai Hospital, when I was doing a check with my husband recently, I found that my husband's chromosomes had abnormal changes. But in his father there are no obvious genetic symptoms, want to consult a man with chromosomal abnormalities can have children?
Chromosomes are carriers of genetic material, the forms of dna (DNA) and nucleoproteins that appear when cells divide, Antai Hospital said. The number of somatic chromosomes in normal people is 46, and it has a certain morphology and structure. Abnormalities in the morphological structure or number of chromosomes are called chromosomal abnormalities, and diseases caused by chromosomal abnormalities are chromosomal diseases. There are more than 100 kinds of chromosomal diseases that have been found, and chromosomal diseases can often cause miscarriage, congenital stupidity, congenital multiple malformations, and cancers in the clinic. The incidence of chromosomal abnormalities is not uncommon, reaching 0.5 million in the general neonatal population. 5％－0． 7％。
In early spontaneous abortion, about 50%-60% is caused by chromosomal abnormalities in the "embryo". The main reasons for the occurrence of embryonic chromosome abnormalities are positive anti-embryonic antibodies (greater than 1:64), intrauterine environment abnormalities, such as mediastinum, fibroids, polyps and endocrine abnormalities, followed by exposure to ionizing radiation, chemicals, microbial infections and genetics during pregnancy.
It is worth noting that chromosomal abnormalities leading to early miscarriage refer to chromosomal abnormalities in the embryo, not to chromosomal abnormalities in the couple,99. 99% of embryos have abnormal chromosomes, and the couple's chromosomes are normal; while the couple has one chromosomal abnormality, the embryo does not necessarily have an abnormality. Clinically, many doctors and patients believe that chromosomal abnormalities in couples can lead to miscarriage.
Couple chromosomal abnormalities do not lead to habitual miscarriage, couple chromosomal abnormalities are carrying hereditary type, that is, mild chromosomal abnormalities, such as balance translocation, inversion [46, XY, t(5, 12)], etc., genetic information is not much, but the chromosomal fragments are displaced, such people have normal appearance and reproductive glands, and will not lead to miscarriage, at best, the offspring born have the same chromosomes as the previous generation. The so-called dragon gives birth to the dragon, and the phoenix gives birth to the phoenix. If one of the couples has a carrier chromosomal abnormality, it must be aborted, then is there no one in the world without chromosomal abnormalities? It can be seen that when screening the causes of habitual miscarriage, the chromosomal examination of couples should not be taken as the focus, and it is even more wrong to list those with abnormal habitual abortion of couples as incurable diseases.
Chromosomal abnormalities in embryos are the result, not the cause. The main reasons for the abnormal occurrence of embryonic chromosomes are positive anti-embryonic antibodies (greater than 1:64), intrauterine environment abnormalities, such as mediastinum, fibroids, polyps and endocrine abnormalities, followed by exposure to ionizing radiation, chemicals, microbial infections and genetics during pregnancy.
Therefore, Antai Hospital recommends that if one of the couples with a habitual miscarriage has a mild chromosomal abnormality, do not consider it an incurable disease and abandon treatment. The corresponding person's chromosomes should be checked according to the family lineage, such as parents, grandparents, siblings, if they are also the same as your chromosomes, does not mean that your chromosomal abnormalities are normal inheritance, not the cause of miscarriage? We have treated more than 300 such patients, who have more than 300 other reasons in addition to mild chromosomal abnormalities, and most of them have children after treatment.
What should I do if I stop having a fetus? Those who have been diagnosed with fetal cessation (pregnancy), there is no abortion, do not cherish this once-in-a-lifetime opportunity, it is best to make an appointment to Beijing Antai Hospital immediately to do hysteroscopic embryo extraction, preoperative examination of vaginal four-dimensional color ultrasound, electrochemiluminescence immunosteroids 6 items, anti-embryonic antibodies, etc.; intraoperative to see the embryonic status, uterine cavity situation, embryo implantation position, etc.; postoperative check embryo chromosomes and pathology. The implantation site and chromosomes of the embryo can only be found at the time of fetal cessation. Diagnosis is made in the shortest possible time and then treated for the disease.
If you have a history of fetal arrest, uterine cessation, and spontaneous abortion, you should find the cause before your next pregnancy to avoid repeating the mistakes. Select non-menstrual period, electrochemilumine-luminescence to check endocrine and anti-embryonic antibodies; do colposcopy, dynamic digitized hysterosalpingogram and vaginal four-dimensional color ultrasound. Generally, it can be diagnosed, and the time for diagnosis in Beijing Antai Hospital is one day. A clear diagnosis can be contracted for treatment, and the full amount can be refunded if the purpose is not achieved.
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