In three generations of IVF, embryos of couples who have failed many times have repeated large, unpredictable cell fragments.
What is cell debris?
Fragmentation means that there is a small part of the cell membrane around the cell that wraps the cytoplasm, unlike normal cells that contain nuclei, and there is no DNA structure or chromosomal structure in the cell fragments, only a little cytoplasm, which is spherical, elliptical or irregular in size.
How is cell debris produced?
When an embryo encounters its own genetic damage or a poor in vitro environment, it activates and initiates the self-protection mechanism of DNA repair, and when the problem continues to become serious and cannot be solved, the embryonic cells can remove the DNA damage through the apoptosis mechanism to avoid passing these genetic damage to offspring.
The number, size and distribution of debris are an important basis for judging the embryo level, and are closely related to the embryonic development potential, embryo implantation rate and clinical pregnancy rate!
Medically, embryo fragments are divided into 4 grade criteria
1. The fragmentation rate of the first-level embryo is between 0 and 5%, the cells are uniform, the transparency is high, and the fragments have no impact on the quality of the embryo, and can be directly transferred;
2. The fragmentation rate of secondary embryos is between 6% and 20%, the cell morphology is slightly affected, the quality is not affected, and the embryo itself can repair itself, and does not affect the transfer.
3. The fragmentation rate of tertiary embryos is 20%-50%, in this case, the self-repair ability of embryos is useless, and the quality of embryos is extremely low and cannot be used for transfer.
4. The fragmentation rate of fourth-level embryos is as high as 50%, and this embryo is basically eliminated and cannot be used for transfer.
How does IVF reduce embryo fragmentation?
1. Moderate exercise, balanced nutrition, targeted conditioning, strengthening egg activity, following the doctor's advice, and using a suitable ovulation promotion program.
2. In order to avoid the adverse effect of hydrosalpinx on the pregnancy rate of IVF, women should do a good job of pretreatment before IVF.
3. Men actively cooperate with the examination, smoke and alcohol before the treatment, exercise more, appropriately supplement micro-elements and folic acid, and improve sperm quality. 4, choose a good hospital, laboratory culture environment and conditions are equally important for embryo culture, the proficiency of the operator, reduce the exposure time of the embryo.