"Nurse, I have breast lobular hyperplasia after physical examination, and it will have an impact on using this hormone drug to induce ovulation!"
"Miss nurse, I have been receiving stimulation injections for several days, and the doctor said that today I saw more than a dozen eggs in ultrasound, and my eggs have been overdrawn in advance, and they will age early!"
"Nurse, look, since I started to promote the injection I have gained 3 pounds, my stomach is full of meat, so I have been fat, I am so worried!"
"Nurse, during the stimulation treatment, be sure to limit exercise and strengthen food intake to improve the success rate of IVF!"
In the assisted reproductive care outpatient clinic, in the injection room of the assisted reproductive department, patients often encounter similar problems with consultation, which shows that there are still certain misunderstandings in everyone's understanding of IVF ovulation induction treatment. In the face of some rumors and misunderstandings that appear before patients undergo ovulation induction treatment, we need to correctly understand and be prepared.
01
Ovulation induction, eggs will be used in advance,
Will menopause be advanced?
Image source: Shanghai Jiao Tong University School of Nursing Undergraduate Tang Still
This misconception is common, but purely thoughtful. There are about 300,000 eggs on a woman's adolescent ovaries and about 30 per day for decades after that, atresia and apoptosis at a rate of about 30. Even without the use of ovulation induction drugs, only one egg in each menstrual cycle of a woman can mature and ovulate, but this does not mean that only 1 egg in the ovarian reserve is used in a menstrual cycle, in fact, a menstrual cycle usually recruits a large number of follicles, the most sensitive one of which matures and completes ovulation under the action of hormones in the body, while other eggs in the same batch die with it. Ovulation induction injection, mainly so that this part of the originally apoptotic eggs can also grow and mature, which belongs to "waste into treasure, resource recovery", will not consume the "stock" of eggs, so it will not make menopause come early or aging early.
As the name implies, ovulation induction treatment refers to the appropriate use of ovulation induction drugs under the guidance of a doctor, in the menstrual cycle to promote the simultaneous development of multiple follicles to increase the chance of conception A treatment method, mainly for women who do not ovulate or have ovulation disorders, is a clear indication. Like other treatments, ovulation induction treatment can cause some side effects, such as dizziness, nausea, bloating, breast tenderness, low mood, etc., but it can generally be tolerated.
However, it is worth noting that the various drugs used in ovulation induction treatment are prescription drugs, because, as one of the key steps of assisted reproductive technology to assist pregnancy, the reasonable choice of treatment plan, the size of the dosage, the length of time, the complementarity between various drugs, etc. need to be dynamically adjusted under the close monitoring of specialists, otherwise it may lead to multiple pregnancy and even ovarian hyperstimulation syndrome.
Studies have shown that compared with singleton pregnancies, the burden on the heart, liver and kidneys of mothers who conceive multiple births will be increased, and there is a higher risk of miscarriage and premature birth; Severe ovarian hyperstimulation syndrome can lead to hydrops, metabolic abnormalities, endocrine disorders, and more. Therefore, although IVF ovulation induction treatment is "waste utilization", it cannot be "developed" at will, and it is only safe to apply under the guidance of professional doctors in formal medical institutions.
02
Can ovulation induction injections make people fat?
As the saying goes: everyone has a heart for beauty, fat and thin will always be one of the most concerned issues for the majority of female compatriots. Some patients often complain that they gain weight after ovulation injections. This phenomenon, on the one hand, is because ovulation induction injections can increase estrogen levels, so that water is trapped in the body, resulting in weight gain or edema in parts of the body. But this phenomenon is temporary, with the end of treatment, drug metabolism, hormone levels return to normal, this temporary "water retention" will be excreted with the body water, weight can return to normal, edema will gradually disappear.
On the other hand, some women think that restricting exercise and strengthening food supplements can improve the success rate of IVF, so big fish and meat, abalone wing belly take turns, which naturally leads to excess energy, fat accumulation, and weight gain. In fact, during ovulation induction treatment, it is recommended to eat a balanced and light diet, appropriately increase the intake of high-quality protein, such as fish, shrimp, eggs, milk and crude fiber foods, such as celery, spinach, etc., which not only helps to promote follicle development, but also helps to maintain normal weight.
Image source: Shanghai Jiao Tong University School of Nursing Undergraduate Tang Still
At the same time, with the orderly use of ovulation induction treatment drugs, the follicles in women's ovaries gradually grow, and the volume of the ovaries increases; Therefore, during the stimulation treatment, it is recommended to match an appropriate amount of exercise every day, such as walking, jogging, yoga, etc., to increase the body's energy expenditure, which can also help the weight to return to the original level quickly after stopping the drug; However, strenuous exercise such as heavy physical exertion and rapid body twisting should be avoided to avoid increasing the risk of ovarian torsion and rupture. In addition, care should be taken to avoid sex as much as possible, in addition to increasing the risk of ovarian torsion and rupture, sexual life may also lead to vaginal infection, affecting the smooth progress of puncture egg retrieval and embryo transfer surgery in the later stage.
03
Having IVF increases the risk of breast cancer
In recent years, there have been some false reports and rumors: ovulation induction may increase the risk of cancer; There is also gossip that a certain celebrity suffered from breast cancer because he had done IVF treatment many times. The American Society for Reproductive Medicine (ASRM) guidelines state that the available data suggest that patients undergoing ovulation induction therapy with IVF do not have a significantly increased risk of breast cancer. In fact, breast cancer mainly occurs in women who carry the gene for breast cancer, and bad lifestyle habits are also the main factors that increase the risk of disease.
Like the normal population, some patients who do IVF will develop breast cancer. However, the results of a large sample of Swedish scientists show that women who do IVF have a slightly lower risk of cervical carcinoma in situ and breast cancer than the normal population, so IVF itself does not increase the risk of breast cancer.
Image source: Shanghai Jiao Tong University School of Nursing Undergraduate Tang Still
It can be seen that IVF ovulation induction treatment is actually only to save those follicles that should disappear, and include them in the team that continues to grow, so that they can also grow into mature follicles, thereby helping patients to obtain more eggs, which will not lead to the occurrence of malignant diseases of the reproductive system, and the weight gain caused by it is also temporary, so we don't have to worry too much.
Author|Hu Yulian Nurse in charge, Department of Assisted Reproduction, International Peace Maternal and Child Health Care Hospital, China Welfare Association
Review|Professor Zhang Yaqing, doctoral student/postdoctoral supervisor, director of the editorial department of the Journal of Shanghai Jiao Tong University School of Medicine, former dean of the School of Nursing, vice chairman of the Medical Science Popularization Committee of the China Science Writers Association
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