It is said that test tube mothers should break through three levels in a row: blastocyst off, implantation off, and fetal heart off. So it is not difficult to understand why the most cheerful girl has begun to become entangled after transplantation.
I am afraid that if I am not careful, my precious embryos will be lost!
What causes affect implantation?
1. Embryo quality
When it comes to fertility, a woman's age is crucial. In general, even if a man is over fifty years old, as long as his testicles can produce sperm, the effect on fertility is not obvious. For women, especially after the age of 35, the ovarian function is a linear decline, and the egg quality will naturally become very poor (such as chromosomal abnormalities, etc.).
If the quality of the woman's eggs is not good, the embryos formed will be unhealthy, weak vitality, and poor implantation ability. If it is transferred into a woman's uterus, such embryos will not implant to a large extent.
So egg quality, embryo quality is the foundation, is the premise.
Second, the uterine environment
Determine whether the embryo can implant and the reason for the endometrium, if the thinning of the endometrium of the woman is more harmful to the woman, it will cause the appearance of symptoms such as menstrual irregularities, uterine blood and vaginal discharge abnormalities in women, which will have a great impact on women's normal birth, work and life.
The endometrium is thin for IVF, and the implantation of early embryos is very unstable, and even causes the consequences of not being able to implant. Even if the embryo is able to implant normally, the embryo will not receive adequate nutrition, which can easily cause miscarriage, so as to reduce the success rate of IVF.
Among the many complex factors that determine embryo implantation, biochemical problems are also very important, roughly equivalent to what experts often call endometrial receptivity, which has not been thoroughly studied in medicine. In addition, various diseases involving the intima, such as inflammation of the intima, fibroids, adenomyosis, etc. The uneven fertility of the "soil" that leads to fertility and thinness, and the fewer places that can be transplanted, are also important influencing factors.
3. Endocrinology
In general, after embryo transfer, reproductive medical specialists will inject progesterone into the woman to achieve the synchronization of luteal function with the development of the embryo. Uterine cavity problems are common, such as uterine contractions, as a result of uterine contractions may leave the embryo out of bed or in a free state after implantation for a few days after the transfer (including after natural pregnancy). Therefore, luteal support is mainly to strengthen the function of the endometrium and prevent the occurrence of ectopic pregnancy and miscarriage.
If the endocrine level is not reached, it is very likely that the embryo will not be able to implant and reduce the success rate of IVF.
Fourth, psychological factors
Many patients always have various worries and anxieties after receiving embryo transfer surgery, and they are in a state of nervous tension all day long.
Some experts have done relevant research and show that if there is anxiety and uneasiness for a long time, it can lead to endocrine disorders and affect embryo implantation.
After all, women's endocrine is very fragile, and it can even cause emotional diseases.
5. Other factors
1) Immune factors
Embryo implantation is a semi-isograft that relies on the regulation of the immune system, and implantation failure (RIF) may also be associated with abnormal immune function in the body.
2) Prethrombotic state
The study found that serum antithrombin III (AT-III) activity decreased during IVF-ET treatment in infertile patients with RIF, and the serum D dimer level and platelet aggregation rate increased, and it was speculated that the patient's prethrombotic state was related to the occurrence of embryonic RIF. Patients with RIF may also have a risk factor mouth for inherited or acquired thrombosis.
3) Transplant operation
Meticulous embryo transfer techniques are undoubtedly essential for a successful pregnancy.
Researchers have long recognized that the presence or absence of blood staining of the transplant tube, the placement of the embryo in the lumen, and the type of transfer tube all affect the implantation and IVF outcomes of the embryo.
It will stimulate the vagina or cervix, causing the production of local oxytocin and the release of prostaglandins in the uterus, which increases the activity of uterine contraction.
"Mom's squinting edge" has a good effect on the decline of ovarian function and poor egg quality caused by various factors. And it can regulate immunity in both directions, anti-inflammatory response, can fight endometrial inflammation and ectopia, thereby improving the environment within pregnancy. It can significantly increase the rate of first-degree eggs, high-quality embryos, and embryo implantation in IVF patients.