Repeated embryo transfer failures are a roadblock for many IVF mothers on the road to a good pregnancy. Embarking on the road of IVF with the determination of "must be cherished", I did not expect to meet with the narrow road of "repeated transplant failure", which was simply sad and reversed into a river.
To know that although the IVF technology is advanced, it is not a panacea, it has a very rigorous medical step, step by step to complete each IVF link, in order to successfully conceive the baby, repeated transplant failure of patients, may wish to carefully check the cause with the help of doctors, find the right cause in order to treat the symptoms. Today Xiaobian will take you to understand the reasons for transplant failure?
Embryo quality
The quality of the embryo is a key factor in determining the success of IVF, and there is no doubt that the higher the embryo level, the higher the success rate of the transfer.
The reasons for the poor embryo quality are mainly the following aspects, one is the poor egg quality, the second is the poor sperm quality, and the third is the serious fragmentation of the embryo at the cleft stage.
In the final analysis, the quality of sperm and eggs is crucial to the formation of embryos and their development potential, and both husband and wife should improve their lifestyles, quit bad eating habits and living habits, do not contact toxic and harmful substances, maintain a healthy physique, try their best to provide high-quality sperm and eggs, and make the first pass for the starting line of embryonic babies.
Maternal uterine environmental factors
Endometrium can be said to be an important factor in the success of test tube transplantation can not be ignored link, such as the endometrium thin does not reach the standard to 8-12cm, too thin even if the transplantation is successfully implanted then there is a risk of miscarriage, too thick and not conducive to rooting, and the uterine environment is abnormal, such as polyps, fibroids, adhesions, endometritis, uterine basal destruction, and other various lesions will affect the outcome of transplant implantation.
Both husband and wife have chromosomal abnormalities
Chromosomes are full of human genetic material, and their importance is self-evident, there are 23 pairs of normal people, the first 22 pairs are called autosomal, and the 23rd pair is called sex chromosomes. The main reasons for the occurrence of abnormalities are pairing, deletion, inversion and separation between chromosomes, etc. In in vitro cultured embryos, the incidence of chromosomal abnormalities can reach 30-40%, and there is no difference between these embryos and normal embryos from the outside, of course, preimplantation genetic screening technology can choose chromosomally normal embryo transfer, but there are still about 30% of patients who have transferred PGS screened embryos and still have repeated failures of unknown reasons.
Immune antibody factors
If the maternal immune mechanism is abnormal, pregnancy will lead to rejection of the embryo by the endometrium, abnormal increase in the activity of systemic or local natural killer cells, which may have a toxic effect on the embryo and hinder the planting results.
Coagulation dysfunction
The dependence of embryo implantation on the blood supply of the endometrium, insufficient blood supply to the endometrium, and thrombosis in the small blood vessels of the placenta can cause a decrease in the chance of embryo implantation or an increased risk of miscarriage. Diseases that cause coagulation abnormalities include "antiphospholipid syndrome" and "thrombophilia", which can be prevented and treated with aspirin, corticosteroids, and low molecular weight heparin.
Psychological factors
Women who do IVF will face a lot of pressure, especially the most difficult days after transplantation, expectant mothers out of the desire for the baby, afraid of causing the embryo to not implant because of themselves, the heart will be uneasy, all day in a state of nervous tension, the most prone to anxiety and uneasiness, resulting in endocrine disorders, and then affect the implantation of the embryo.
The above is to sort out the factors of repeated transplant failure, etc., in addition, there are 10-20% of repeated transplant failures in the clinic for unknown reasons. If repeated failures, follow-up treatment does not achieve the expected effect, you can comprehensively consider your own physical condition, time cost and economic cost, etc., and choose a more suitable for your own situation of assisted reproduction methods.
Finally, Xiaobian warmly reminds that whether it is natural conception or IVF conception, we must respond scientifically to the entire pregnancy preparation process, make sufficient psychological preparations, adjust the mentality to meet all the unknowns and good pregnancy in the later stages.