What is more desperate than hopelessness is the absence of hope; what is more painful than "can't" is "dare not."] While some people complain about the difficulties on the road to fertility, others, for various reasons, are deprived of the opportunity to reach the end point before they are on the road. 】
After a hard october pregnancy, all I want to have is a child, a healthy and lively hope with an infinite future. However, not everyone can get what they want.
According to a study, on average, a defective child is born every 30 seconds on the mainland, and a total of 30 million families have given birth to children with congenital disabilities or defects, accounting for about 1/10 of the total number of families in the country.
What a terrible number, even with foolproof preparations, genetic diseases and congenital diseases are always overwhelming.
For onlookers, this number may simply be surprised and then left behind. But for a family, this probability is the unbearable weight of life, and for a child, this probability can become a dark abyss throughout their lives, a disaster that we need to do our best to block for them.
With the maturity and application of three generations of test tube technology, many people's first impression of it is "I heard that genetic diseases can be detected, and genetic disease transmission can be avoided...", but how to operate this technology, what benefits and limitations there are for ordinary people, but few people can say clearly.
However, I don't want to waste a lot of space explaining the principles of this technology, and I often say that professional things are left to professional people. For fathers-to-be and mothers-to-be, it is enough to figure out two issues.
First question: Who is suitable for three generations of IVF embryos?
Second question: What are the advantages and disadvantages of this technology?
First of all, I will briefly explain the difference between three-generation test tube technology PGD and PGS, although both are genetic examinations of embryos, but PGD is mainly for family genetic diseases or personal major diseases and targeted diagnosis, while PGS is mainly for the screening of abnormal chromosome structure and number.
Both take the same technical means, the purpose is to block the occurrence of genetic defects, there is no distinction between high and low, only to adapt to the differences of the population, which is more suitable for themselves, the doctor will give the most suitable diagnosis and treatment plan according to the specific situation of the patient, do not have to be too entangled.
So, who would recommend doing three generations of IVF?
First group: Expectant parents with a family genetic history.
Once, in the face of ruthless probability problems, for families with a family genetic history, or one of the couples carrying the disease-causing gene, there were only two choices in the matter of having children, either to take a risk or to be completely dead, but the third generation of test tube technology provided a third option.
For example, if both husband and wife carry the recessive genetic disease gene of thalassemia and do not do PGD screening when they are trying to conceive, the possibility of children suffering from thalassemia in the future is 1/4, and there is no room for luck. By genetically diagnosing embryos before transplantation in vitro, embryos without defective genes can be selected for transfer, thereby blocking the inheritance of disease-causing genes and allowing regrets not to repeat themselves in the next generation.
Second group: pregnant mothers with recurrent miscarriages.
For many women, in the process of pregnancy preparation, there is a more painful thing than "not being able to conceive", that is, repeated fetal abortion.
Whether it is natural conception or IVF fertility, confirming pregnancy is only the first step towards success, and there is still a 20% elimination rate in the 10 months of life.
After experiencing the joy of a new life, being ruthlessly deprived of hope is a blow that is too cruel. For all parents who aspire to a new life, this is the most painful experience.
Although there are many reasons for this result, with the deepening of research in the field of genetic genetics in the scientific community, many doctors believe that chromosomal abnormalities are a major cause of embryonic non-development and early miscarriage.
In this case, through three generations of screening, the embryo chromosomes can be examined at the source, and normal embryos can be selected for transfer, so that expectant mothers can be spared physical and mental torture.
The third group: ivory mothers who have been transplanted multiple times without implantation.
Why do I take a lot of eggs at a time and not match them into embryos?
Why do you always say that the embryos are of good quality, but always fail to implant?
Is there an immune rejection, mood, or a problem with the uterine environment? Many people who have experienced one or more failed test tubes will repeatedly explore the details of the process, try to find their own flaws, and even fall into self-blame, depression and can not extricate themselves. However, when you have searched for various reasons and still don't know where the problem is, it is better to look for the cause from another angle.
Even the highest level of embryologists cannot see genetic problems with the naked eye. Some people may think that both husband and wife are genetically fine, and the embryo must be normal. This idea is wrong, and normal couples without genetic problems will also produce embryos with abnormal chromosomal abnormalities.
You know, in the process of egg and sperm binding, chromosomes are also recombining, if there is confusion in this process, it will cause abnormal embryonic chromosomes, and it will fall short. For example, if you raise 6 blastocysts at a time, assuming that three of them are normal and three are abnormal, then each transplant is a gamble. In case of bad luck, the transfer is an abnormal embryo, and the later result is likely to be no bed, early miscarriage, fetal stoppage... At this time, if PGS is done in advance, you can know in advance which are normal embryos, thereby reducing the risk of ineffective transfer.
The fourth group: the elderly fertility group.
Although a person is pregnant, not ovulation can be decided, but the ovary regular ovulation, is definitely an important part of fertility, whether it is a test tube embryo, a healthy, good quality egg, can largely determine whether to conceive.
From the perspective of age alone, as women age, it will not only lead to an increase in the probability of abnormal chromosomes of eggs and embryos, but also an increase in the abortion rate and a decrease in the live birth rate, but also cause genetic diseases. This is related to the aging of the egg, the fact that after the sperm and the egg are combined, there is no way to carry out normal division.
Although this fact is very cruel, we have to admit that age takes away not only beauty, but also healthy eggs, which is a normal natural law of the human body, and no one can reverse it. The only thing we can do is to use the third generation of technology to eliminate abnormal chromosomes and genetic diseases, improve the pregnancy rate to a certain extent, and maximize the escort of the baby's health.
In the traditional concept of Chinese, it attaches great importance to genetic inheritance, hoping that their children can inherit the best genes, not to mention the disease, it is not allowed to carry. Therefore, more than one parent who loves their son has proposed to the doctor: "Give us a good screening screening, it is best to remove all bad genes, is it okay?" ”
May be in the eyes of many people who do not understand, the third generation of test tube technology on the detection of genes, just like buying vegetables to cook, throw away the bad leaves, only keep the freshest on the line, but in fact, professional genetic testing is like demining, there is no thunder do not know, where the mine does not know, and the whereabouts of this mine will be unpredictable, even if the use of the most advanced detection technology in the United States, can only screen more than 400 genetic diseases, and can not prevent the occurrence of all diseases.
However, just as we cannot control the life of our children, but we can provide support, although we cannot let the children in the embryonic stage once and for all as everyone expects, we try to reduce their shackles as much as possible, which can make them go further and easier, which is also the first gift that parents give them.