For expectant mothers who want to get pregnant through IVF, of course, they all hope to succeed in getting pregnant at one time, but there will be many unforeseen situations during the entire IVF fertility period, and some people always have repeated transplant failures in the transplantation stage, which is more disheartening, thinking that if it still fails, should it be abandoned? So today, Beilai test tube will give you a specific analysis of what factors are related to transplant failure.
The most widely accepted repeated failures of IVF transfers are defined as infertile patients under the age of 40 who have undergone at least 3 cycles of fresh or freeze-thaw embryo transfers, and who have transferred at least 4 high-quality embryos or 2 blastocysts that still cannot conceive and have not obtained clinical pregnancy.
The first is the embryonic factor, which is an important factor that determines the success of the transfer. Abnormal number or structure of chromosomes, genetic abnormalities and embryonic development potential are important factors affecting embryo quality. The quality assessment of the embryo is particularly important. At present, the quality assessment of embryos mainly uses embryo morphological scoring. Although this scoring method is convenient and practical, and there is a certain correlation between the score and the implantation rate of the embryo, it does not truly reflect the quality of the embryo and the ability to implant and develop.
Poor embryo quality is closely related to poor egg quality. Egg quality is related to age, body mass index, ovarian or pelvic surgery, or some other factor, so there is an option to adjust the ovulation promotion regimen in light of the woman's actual condition to obtain high-quality eggs to improve embryo quality.
Patients who have multiple transfers of high-scoring embryos without pregnancy may also consider blastocyst cultures to further screen embryos. Since blastocysts are embryos that have undergone further screening, the implant success rate of the transfer is higher.
Uterine factors are also not negligible. Just as fertile soil is needed for farming, the occurrence of planting requires a suitable endometrium. When uterine abnormalities occur, such as sub-uterine malformations, endometrial polyps, submucosal fibroids, adenomyomas, uterine adhesions, endometrial fibrosis, endometritis, and most commonly, hydrosalpinx, water poured into the uterine cavity, causing inflammatory changes in the uterine cavity, etc., may affect the implantation of the embryo. Clinically, B-ultrasound is widely used to measure the thickness, morphology, morphology of the uterine cavity and blood flow to assess the ability of the endometrium to accommodate embryos.
In short, the IVF process is long and full of uncertainty, once on this road, no matter what difficulties will be faced in the middle, please do not be sad, Belai IVF hopes that you will always maintain an optimistic and good attitude, no matter what the final result is, on this road, we will do our best first.