February 4, 2022 when does not need to exclude the placebo effect of the drug. There will always be some people who will jump out to accuse me: poor medical literacy, do not understand evidence-based medicine, and are inferior to second-class hospitals

February 4, 2022 When the placebo effect of the drug is not needed to be ruled out.

There will always be some people who will intermittently jump out to accuse me: poor medical literacy, do not understand evidence-based medicine, not as good as the level of doctors in second-class hospitals, etc., some deliberately black do not mention, some look is not, but my peers, medical students or new clinics.

In fact, because of their lack of knowledge, they have not yet recognized the limitations of evidence-based medicine in clinical practice, these people are actually worth my writing articles to explain and progress, it is recommended to read more of my previous articles, you will learn a lot.

For example, some doctors say that my scientific literacy is low, I do not know how to exclude the placebo effect of drugs, and think that all drugs need to exclude the placebo effect, which is actually a completely wrong concept.

Let me explain:

Previously written: Novartis spinal muscular atrophy gene therapy Zolgensma, priced at $2.47 million, was only phase II, no randomized control, no placebo, only used 21 patients, looked at the efficacy and safety of the one-arm study, in 2019 was approved for marketing by the FDA.

Not only that, but there are many similar drugs.

This fact confirms that the use of drugs to treat disease does not necessarily require the exclusion of placebo effects.

When the doctor determines that a disease cannot be self-healing, such as spinal muscular atrophy, or advanced malignancy, that is, it will inevitably become worse and worse after not treating, then as long as some patients have a significant improvement after taking the drug, we directly think that the drug works, even if there is no placebo to compare. Think about it, right?

So, the placebo effect needs to be ruled out only for some cases, not all of them, in medicine, when do you need to rule it out? When medications do not work well and the disease may heal itself.

Some doctors or medical students take a good look at the above two paragraphs, and don't be completely brainwashed by the placebo effect, which is only applicable to part of the current medical situation.

The last sentence is written to these doctors, when their level is low, think more, learn more and understand knowledge, you need to see a lot of correct objective knowledge, try to see the comprehensive. Before blaming anyone, don't blindly draw conclusions, be sure before you say.