The author | Brother Cat comes from | source Big Cat Finance
There is such a part-time job, sometimes 7 days to earn 100,000, sometimes 3 days to earn 15,000, package food and housing, cash is settled, the work content is lying in the hospital, you can brush the mobile phone to read books, and the nurse sister comes to measure blood pressure, measure a weight, draw a little blood, etc., but what dirty work does not have to be done.
Do you want to, want to come?
There are still many job opportunities in this place, what exactly? It's about trying drugs.
Sometimes some mysterious projects, complete the experiment can earn 180,000, how many people's annual salary is far from this number.
Why can you give so much money, what kind of industry is the drug test? Brother Cat will come to tell you about it.
After the release of "I Am Not a Medicine God", many bigwigs in the medical circle were very resistant.
Say that the director only cares about rendering emotions and ignores the truth - why are these drugs so expensive? Because the R & D expenses invested in the early stage are sky-high, basically in the unit of 100 million or even billion, if you can't always get back the cost, no one will develop it in the future.
So what is this money spent on?
Scientists' salaries are small heads, and the big heads are experiments.
A new drug had to be experimented on mice, in pigs, and in monkeys. In just two years since the new crown, the price of experimental monkeys in the world has soared from 15,000 to 100,000, and the cost is evident.
But humans and animals are not the same, and the next thing to do for people is called clinical trials:
● Phase I: Toxicity tests are conducted in the middle of healthy populations to determine that more is the safe amount;
●Phase II: Testing the efficacy and safety of new drugs in clinical patients;
●Phase III: After summarizing the clinical data of the first two phases, new drugs can be submitted for approval and marketing, and after successful listing, more patients will be recruited for clinical trials to achieve mature and wide application;
● In the case of good luck, this drug was successfully put on the market, and there was a four-phase clinical return visit to investigate the use of drugs, but it was not mandatory in China.
The first three phases of clinical trials in humans are steps that must not be omitted.
Where do the contents of "dosage", "precautions", "adverse reactions" and even "contraindications" on the drug box and instruction manual come from? It was derived from clinical trials.
And the drug trial people are the people who do clinical trials.
In China, on average, more than 300 new drugs are introduced every day, and the demand for drug trialists is very large, and the rewards offered are also very generous.
Although this industry comes to money quickly, because no one has eaten before, I don't know what impact it has on the body after eating, and the risk is not low.
A young man named He Jinhu regretted his drug trial experience very much, "If you start again, you will not choose to try the drug."
In 2009, he went from Shandong to Beijing as an apprentice, earning 800 yuan a month, and he was very poor. One day in 2010, he saw a drug trial advertisement on the Internet "3 days 2500", the physical examination passed, a few days later, He Jinhu successfully completed the first drug trial, 2500 yuan easily arrived, nothing happened.
This money was earned easily, and since then it has been out of control, frequently participating in drug trials, and unwilling to go out to find other jobs.
Over the course of two years, he participated in more than a dozen drug trials, the most intensive, once twice in a month.
In August 2010, a drug trial changed his life.
▲ He Jinhu, who was healthy at that time, now needs to take many breaks to carry a bucket of water Picture source: Phoenix Satellite TV documentary "I bet my life on tomorrow"
The pharmaceutical company called He Jinhu and said that there was an experiment that could take 10,000 yuan in more than three months. He Jinhu checked in as usual, signed the "Informed Consent Form", planned to send some money to his home after trying the medicine, and could also change a new mobile phone for himself.
More than ten seconds after the injection, He Jinhu felt that the part of the injection was very painful. Soon there was a strong drug reaction, thirst, panic, headache, and the pulse even dropped to 40 beats per minute. Such a clinical response, the doctor is also helpless, the electrocardiogram has been showing arrhythmia, treatment for three days, He Jinhu was discharged home.
But his heart can no longer recover health, always feel chest tightness, chest like a stone pressed, and even more can not do a little more intense exercise, the drug test career is broken, the job can not be found again.
There are also some people's sequelae, which directly lead to "no face to see people".
Shen Yuchen, a young man in Wuxi, Jiangsu Province, is a post-90s, because the cultural level is not high, the salary is also low, just after accidentally entering the drug trial industry, he feels that he has picked up a big bargain, frequent drug trials, a drug trial in 2010, let him regret his life.
After the drug test, he was highly paralyzed, his mouth could not be closed and his eyes could not move, and the mask never left his face. The skin of the body has also become very rough, and it will "molt" in the autumn and winter, and the cleaning of the home can sweep away the dander of the half dustpan, and the weight has also soared, from 140 pounds to 200 pounds.
After such a thing, will the pharmaceutical company treat the rehabilitation all-inclusive? Not.
Because the drug tester signed only a thick stack of "informed books", from dozens of pages to hundreds of pages, basically no one looked closely. They had no specific concept of risk before they participated in the experiment, and no one warned:
Don't talk about the drug trial person himself, there are reporters who secretly visit to do the drug trial intermediary, commonly known as the drug head, and when training, they are also educated that "the efficacy and safety of the drug are more than 90%, absolutely assured.".
If something happens, the hospital where the drug tester is located will be rescued, but if there are sequelae, some will symbolically give a little compensation, and some will not even compensate, because the drug tester has signed the "Informed Letter".
In the most serious case, people are gone, and there is not much money lost:
This was obtained after the husband of the deceased had been fighting for 4 years.
In fact, most of the drug trialists in the early years were scientific researchers and medical students.
When Tu Youyou developed artemisinin, when the human trial began, the scientists who did the research together signed up, and Tu Youyou took twice as much as others, and she said that it was more convenient for her to take it:
▲Image source: TV series "Meritorious Service"
But the dose is twice as high as others, the risk is also higher, and Tu Youyou later developed toxic hepatitis.
Now, on the bulletin boards of some colleges and universities, especially on the campuses of medical colleges, you will often see some notices that recruit students to volunteer "subjects", and medical students do this line themselves, and the registration is also very enthusiastic.
However, this number is limited after all, and there is simply not enough sample data, so it is still necessary to recruit people who are paid to try drugs for the society.
Most of the people who came to participate in the drug trial were the bottom of the life difficulties and urgent need for money, and in recent years, it has attracted a large number of young people who are bankrupt or crazy to owe online loans:
Coupled with the promotion of the drug heads, many people will be "addicted" after experiencing it once and feel good.
These people who have been trying drugs for a long time, once a drug has irreversible and serious consequences on the body, they will no longer be able to pass the physical examination, and they will not be able to test the drug in the future.
Many of them are unemployed before they try drugs, so what can they do if they can't try drugs? Switch careers as a medicine head, introduce more people to join, and earn referral fees.
It can be said that once you enter the circle, you can no longer go out, and you are getting bigger and bigger with the pharmaceutical industry.
Although many drug heads used to be drug trialists, after they became medicine heads, in the face of interests, they often broke the bottom line, after all, their income is to earn referral fees by pulling people's heads, and the list is less earned.
There are medicine heads that directly teach applicants to cheat to conceal their blood donation experience:
They also drilled the loopholes in the drug taking regulations, and the common practice in the hospital was to require the drug tester to try the drug for 3 months and not continue to try the drug.
This provision actually makes many drug testers very dissatisfied: there is a lack of money to earn money, and I have to wait for the month, and what do I eat when I wait.
So the drug leaders "kindly" handed over the second trick - to find a hospital that is not connected to the Internet to try drugs.
As for the two drugs taken in a short period of time, they are not responsible for what consequences they will have on the body when they are combined.
Do you think that's the end of it? There are also darker operations.
There is an unspoken rule in the drug trial circle.
Drug trial risk formula: the number of money ÷ days = the danger of the drug.
In layman's terms, the higher the daily salary, the more dangerous the medicine is behind it, and some intermediaries will suggest that the drug trial person should not do too expensive, there will definitely be harm:
But there are also black medicine heads that pit people.
Some dangerous drugs, the daily salary of the test drugs prescribed is very high, which scares off the drug testers and delays the recruitment of enough people.
In the end, the drug head shook a shot, reduced the price of recruitment, after the money was given less, the drug trial person felt that the drug should be quite safe, and soon it was full, and the more the drug head earned.
Having said all this, everyone may have to ask, how can the drug trial industry be so dark, how can it still be allowed to flourish?
Everything has two sides, drugs are ultimately used to treat diseases and save people, and the research and development of drugs must continue.
For healthy people, taking medicine to leave sequelae on the body will be very regrettable, but for some patients it is irrelevant - instead of facing the death date of the doctor's "judgment" and the sky-high treatment fee that cannot be paid, it is better to try the new drugs in the experimental stage, as the old saying goes, "dead horses are live horse doctors".
Moreover, more and more reports of "miracle" stories have encouraged patients to choose this path:
This has emerged, in clinical trials, the number of healthy people in the first phase of the drug trial is small, and they need to be recruited at high salaries, while the larger number of phase II and Phase III experimental subjects is overcrowded, all of which are patients waiting for the experimental drug to save their lives.
In particular, drugs for the treatment of "severe diseases" and "terminal diseases" such as cancer not only do not lack patients, but also have to entrust people or queue up to get the opportunity to try drugs:
This is not nothing, in order to survive, let alone give rewards, let alone free trials, not to mention when a guinea pig, some cancer patients in order to treat diseases, dog medicine is also willing to eat:
An old man named Joe Tippens in the United States once said on the Internet and in interviews that during the advanced treatment of lung cancer, he ate fenbendazole for two months under the recommendation of a veterinarian, and the tumor disappeared.
The news spread to the domestic cancer patient circle and quickly exploded, and many patients tried to eat while chemotherapy. This unpopular veterinary drug is also suddenly hot, imported drugs once increased in price month after month, and some domestic veterinary drug manufacturers also packaged it as an "anti-cancer package".
Although experts at home and abroad have questioned the conclusion of fenbendazole for the treatment of cancer, the number of cancer patients who have tried fenbendazole in China is increasing, and the number of people is as small as hundreds or thousands.
When people are desperate, they are willing to try anything in order to survive.
The world's pharmaceutical giants are concentrated in Europe and the United States, but due to the high per capita income of their own countries, the price of recruiting drug trialists is high.
In order to save costs, they prefer to look for drug trialists in other countries.
In the early years, pharmaceutical giants were very fond of conducting clinical trials in China, and the Us "Business Week" article entitled "Drug Testing In China" wrote: "The trials conducted by Western companies in China have benefited China a lot, and the Swiss Roach Pharmaceutical Company invested more than 50 million US dollars in trials in China last year (referring to 2006).
However, a drug trial accident in 2003 limited the drug tests conducted by pharmaceutical companies in China:
At that time, an American viral gene company found 36 AIDS patients for its thymus nuclear protein preparations, many of whom came from a place, Shuangmiao Village in Henan Province (a famous AIDS village), but 7 people died during the observation phase.
Then, regulators found that clinical trials of the drug were never approved and completely illegal.
After such a big accident, management naturally strengthened.
Coincidentally, in 2005, India relaxed restrictions on drug trials, and the pharmaceutical giants all went to India again.
From 2005 to 2010, more than 150,000 people tested drugs in India, and at least 1,730 people died.
In our country, in recent years, this industry has begun to rise again.
On the one hand, the research and development of new drugs in China has accelerated, and the annual R&D investment of the top 10 listed pharmaceutical companies in 2020 has been 27.2 billion, mainly generic drugs, the risk is not large, and a considerable proportion of these investments are spent on test drugs.
In addition, the development of the Internet has made information ubiquitous.
More than a decade ago, the drug test advertisement also had to post a notice, and now, there are not only posts on the Internet, but also internet celebrities who specialize in helping everyone analyze the risk of drug trial and the money is not worth it:
At the same time as the number of clicks is high, the comment area is full of people asking where to try drugs, which is equivalent to pulling a new one to the drug test circle.
The drug trial people who appear from time to time in the TV series have a happy and beautiful ending, and the risks are diluted by various kinds:
▲Image source: TV series "Family with Children"
In "Family with Children", dad, as a healthy person, goes to the institute to participate in experiments, saying that he is contributing to science.
These are easy to make people have an illusion that trying drugs is a routine operation, there is no risk, and it is easy to get money quickly, which attracts more young people to accept and pour into the industry. Many college students turn around after trying drugs and then go back to school to recruit classmates or students to try drugs and become medicine heads.
Fate has long secretly marked the price on each choice, and can only pray that you will not encounter the medicine that makes you regret it.