A: "Doctor, why are they both pregnant, but I am not pregnant?" ”
B: "Doctor, did I not succeed this time because of my bloated stomach?" C: "Doctor, is it not good if the embryos have been frozen, and the success rate is low?" D: "Doctor, I heard that the success rate of blastocysts is high, why don't you move the blastocysts for me?"
Reproductive medicine experts suggest that the reasons for transplant failure are very complex, and individual differences are large, specific to each patient, but also according to the patient's individual situation, do specific analysis, in order to take targeted diagnosis and treatment methods to improve pregnancy outcomes.
If embryo transfer is likened to a farmer's uncle planting crops, the reasons for the failure of the transfer can probably be considered in four aspects, namely seeds, soil, fertilizer and climatic conditions.
One is seeds
(Embryonic factors)
Without a good embryo, it is impossible to get a high success rate; conversely, if there is a "good embryo", it may not be certain to succeed. Because the conventional selection of transferred embryos is mainly through morphological scoring, the development process of the embryo is observed with a microscope (important nodes), and the embryos that look good are selected, and as for whether the embryo has internal (chromosomal abnormalities) abnormalities, it cannot be seen through microscopic observation.
For those who have a chromosomal disorder in one of the spouses, or recurrent miscarriages, or who have abnormal villectomy of the aborted tissue, the third generation of "IVF" technology, that is, preimplantation genetic diagnosis (PGD/PGS) technology, can improve the pregnancy rate. For both husband and wife with normal chromosomes, the main factors affecting embryo quality are: sperm and egg quality, age (the woman is still very serious), embryo culture conditions and the level of embryo culture technology.
The second is soil
(Endometrial factors)
Without good soil, even the best seeds cannot germinate. The main factors affecting the endometrium are: polyps, submucosal fibroids, uterine adhesions and thin lining caused by basal damage. Endometrial testing is mainly observed by ultrasound B, and treatment is mainly through hysteroscopy. Hysteroscopic probing prior to embryo transfer to address adverse factors affecting transfer can improve clinical outcomes.
The third is fertilizer
(Blood supply to the uterus)
Inadequate endometrial blood supply can cause a decline in embryo implant opportunities. Prevention and treatment can be achieved with the use of aspirin, corticosteroids, and low molecular weight heparin.
Fourth, climatic conditions
(Maternal immune mechanism)
Maternal immune mechanisms are abnormal, which can cause the uterus to reject embryo implantation. Increased activity of natural killer cells throughout the body or locally, which has an aggressive effect on the embryo and affects implantation. In addition, factors such as the patient's mood, daily work, living environment, etc. after embryo transfer may affect implantation.
Reproductive medicine experts say that for patients, every egg retrieval is an opportunity, and every transplant is an experience. But please believe that there will always be a reward for your efforts, and as long as you persevere, you will eventually reap the good news.