The country has launched a sequential strengthening of immunization, will Hangzhou follow suit? Who is it for?

On the 19th, the joint prevention and control mechanism of the State Council held a press conference to introduce the latest situation of the current round of epidemic situation in various places.

The epidemic situation in Guangxi Baise is in the stage of closing and clearing;

The new cases of the epidemic in Huludao, Liaoning Province, have been found mainly through centralized isolation and screening, the epidemic trend is good, and the risk of social transmission has been basically controlled;

At present, the epidemic situation in Heihe, Heilongjiang is mainly concentrated in Heihe City, there are multiple transmission chains, and further traceability and case investigation are being carried out in an orderly manner;

Guangdong's Shenzhen, Zhuhai and Dongguan have recently detected clusters of outbreaks caused by imports from abroad. The epidemic situation in Shenzhen Aomi Kerong has been basically controlled, and the epidemic situation in Dongguan and Zhuhai is strengthening the traceability of circulation;

In Wenshan, Honghe and Ruili, Yunnan, the source of infection is still unknown, and the local government is making every effort to accelerate nucleic acid screening in key areas;

The genetic sequencing results of the epidemic in Suzhou, Jiangsu Province, are the Aomi Kerong mutant strain, which is a local epidemic caused by a new overseas import source, which is still in a stage of rapid development, and the local government is accelerating the traceability of circulation;

The genetic sequencing results of the epidemic in Hohhot, Inner Mongolia, are Delta variants, and a local epidemic caused by a new overseas import source has spread to Baotou City. At present, the epidemic is in the early stages, the number of cases is growing rapidly, and there is a cluster of epidemics in crowded places such as units and wedding banquets, and there is a high risk of community transmission and spillover.

National Health Commission:

The mainland has initiated a sequential strengthening of immunization in key areas

Today (February 19) afternoon, the joint prevention and control mechanism of the State Council held a press conference. At the meeting, Wu Liangyou, deputy director of the Disease Control Bureau of the National Health Commission, said that recently, with the approval of the joint prevention and control mechanism of the State Council, the National Health Commission has begun to deploy a sequence to strengthen immunization.

Wang Huaqing, chief expert of the immunization program of the Chinese Center for Disease Control and Prevention, introduced that sequential immunization is a vaccination strategy adopted by using vaccines with different technical routes or different anti-prototype vaccines, according to certain intervals and doses, hoping to obtain better preventive effects and safety. Sequential immunization is a process of continuous improvement of immune strategies and a decision based on scientific evidence.

Previously, target groups over the age of 18 who had been vaccinated with Sinopharm Zhongsheng Beijing Company, Beijing Kexing Company, Sinopharm Zhongsheng Wuhan Company inactivated vaccine or Tianjin CanSino Company's adenovirus vector vaccine for 6 months could be given a dose of homologous enhanced immunization, that is, strengthened with the original vaccine. After the implementation of the sequential enhanced immunization strategy, the target population who has completed the full vaccination of the above three inactivated vaccines can also choose the recombinant protein vaccine of Zhifeilong Koma or the adenovirus vector vaccine of Cansino for sequential enhanced immunization. For the target population, homologous booster immunization and sequential booster immunization can be selected. In addition, the joint prevention and control mechanism of the State Council also approved the homologous enhanced immunization of the new coronavirus inactivated vaccine of Shenzhen Kangtai Company and the Institute of Biology of the Medical Academy. Whether it is homologous enhancement or sequential strengthening, it needs to be implemented in people over 18 years of age who have completed the full vaccination for 6 months.

The research data shows that homologous enhanced immunization and sequential enhanced immunization can further improve the immunization effect, and people who hope to meet the vaccination conditions can take the initiative to vaccinate and vaccinate early, increase health and fuel epidemic prevention.

What are the precautions for sequential immunization?

Hear what the experts have to say

Wang Huaqing, chief expert of the immunization program of the Chinese Center for Disease Control and Prevention, introduced that there are some special precautions for sequential vaccination.

The first is for people over 18 years old, and the second is to complete 2 doses of inactivated vaccination, and these 2 doses are the inactivated vaccine of the new crown virus of Sinopharm Zhongsheng Beijing Company, Beijing Kexing Company and Sinopharm Zhongsheng Wuhan Company. The third is to complete 2 doses of vaccination in the whole process, and the interval between vaccinations cannot be less than 6 months. The fourth is that there is no enhanced immunization, that is, the 3rd injection is not shot, so several conditions should be strictly grasped.

In addition, as with the precautions for receiving the new crown vaccine in the past, including understanding the relevant regulations of local vaccination before vaccination, because it is still the epidemic period, in this process, when everyone goes to the vaccination, they must do a good job of personal protection, including when they are vaccinated, they must truthfully reflect their health status to the vaccination doctor, and the vaccination doctor will judge whether there are contraindications or some delayed situations.

Finally, after vaccination, it is necessary to stay for 30 minutes, and when there is a suspected adverse reaction related to vaccination, if the duration is longer and the symptoms are more serious, one is to report to the vaccination unit, and the other is to seek medical treatment in time.

The World Health Organization supports flexible homologous vaccines and heterologous vaccination programmes

Wang Huaqing, chief expert of the immunization program of the Chinese Center for Disease Control and Prevention, said that there are still many technical routes for global vaccination of new crown vaccines, and the virus is also in the process of continuous change. Based on the research evidence, sequentially enhanced immunization has been implemented in the Americas, both in South and North America, as well as in Some countries in Europe and South-East Asia.

The World Health Organization supports flexible homologous vaccines and heterologous vaccination programmes. Of course, for countries considering heterologous vaccination regimens, the World Health Organization recommends follow-up vaccination with a new coronavirus vaccine with a different technical route from the first dose based on the background that heterologous vaccination and homologous vaccination have the same or higher immunogenicity or efficacy, as well as vaccine accessibility. At present, the World Health Organization is also constantly collecting and accumulating more clinical trial evidence, constantly improving homologous and heterologous basic immunity and strengthening immunization strategies.

Will Hangzhou launch a sequential boost to immunization?

The Municipal Health Commission responded to hot issues

Since the launch of the new crown virus vaccine enhancement immunization work in early October 2021, Hangzhou has received nearly 4 million doses of new crown virus vaccine booster injections, and the vaccination coverage rate of the vaccinable population (over 18 years old and the whole process of vaccination for 6 months) is among the highest in the province, and the enthusiasm of the people in our city to strengthen immunization is high. At the same time, the vaccination work of the elderly has also received great attention, and the following unified reply to the hot issues of concern to the masses is as follows:

Q

Is it necessary for older people to be vaccinated against COVID-19?

Very necessary. Although the scope of activities of the elderly is more limited than that of young people, they will also be infected with the virus through the younger generations at home and the people who are in contact with them, and there have been many elderly cases in the recent domestic epidemic, and in the "1.26" epidemic in our city, there are also elderly people who have been infected with the new crown virus through community activities or visits from relatives and friends. Data at home and abroad show that the risk of severe illness and death in the elderly after infection with the new crown virus is significantly higher than that of adults and children, and since 2021, the preliminary analysis of sporadic clusters of epidemics in many parts of the country shows that the risk of infection, severe illness and death in the elderly who are vaccinated is significantly lower than that of the unvaccinated elderly.

How safe is it to get covid-19 vaccines for the elderly?

The new coronavirus vaccine currently used in the mainland, in accordance with the relevant approval requirements, has carried out phase I, II and III clinical trials for the whole population, including the elderly population, before obtaining the approval of the relevant institutions for conditional listing or emergency use, showing that the vaccine has good safety. Up to now, the number of mainland new coronavirus vaccines has exceeded 500 million doses among the elderly over 60 years old at home and abroad, and the highest age of domestic vaccination against mainland new coronavirus vaccines is 106 years old. The vaccine has shown good safety in these more than 500 million doses and during the vaccination of the elderly, and the adverse reactions in the elderly are slightly lower than those in adults.

Is it necessary for the elderly to get a COVID-19 vaccine booster?

Due to differences in the body's immune function, the level of neutralizing antibodies produced by the elderly after vaccination with the new crown vaccine is lower than that of the young people, and all the population will also have a certain degree of decline in the level of neutralizing antibodies over time after receiving the new crown vaccine. At present, the new crown virus variant strain is repeatedly circulating around the world, and the pressure of "external prevention of import and internal prevention of rebound" in the mainland is increasing, and the risk of infection in the elderly is also increasing. Therefore, the elderly not only need to speed up vaccination, but also need to receive the booster injection as soon as possible in a timely manner.

How should the elderly have high blood pressure, diabetes and other underlying diseases to get the new crown vaccine booster injection?

If there is an underlying medical condition, vaccination is recommended during the plateau; if not sure, consult an vaccinator or clinician to see if your physical condition can be vaccinated with the COVID-19 vaccine.

In response to Omi kerong, how effective is the COVID-19 vaccine to strengthen immunity?

Studies at home and abroad show that on the basis of two inactivated vaccines, different COVID-19 vaccines can enhance the body's neutralization capacity for the Omiljung strain by 8-15 times. In the face of the Omiljung variant, vaccination with the COVID-19 vaccine has become an option for more and more countries.

How safe is COVID-19 vaccine boosting immunization?

Relevant studies have shown that the enhanced immunization of the new crown vaccine does not increase the risk of adverse reactions compared with the basic immunity. At present, the mainland has more than 500 million doses of enhanced immunization, which further confirms the safety of enhanced immunization.

Will there be new changes in the way COVID-19 vaccines are enhanced?

Up to now, the city's new crown virus vaccine enhanced immunization mainly adopts the same homologous enhanced immunization method, that is, after completing 2 doses of inactivated vaccine, continue to receive the 3rd dose of inactivated vaccine to strengthen immunization. According to the latest deployment of the National Health Commission, the new crown vaccine heterologous (sequential) enhancement of immunization will be launched in the near future. At that time, the city will be in accordance with the unified deployment of the state and the province, and the new heterologous (sequential) enhanced immunization method will be added to boost the city's new crown virus vaccine to strengthen the immunization work.

What is heterologous (sequential) boosting immunity?

Sequential vaccination refers to the same vaccine of different technical routes of interval vaccination (alternating vaccination), as far as the new crown virus vaccine is concerned, if the new crown vaccination has previously completed two doses of inactivation process, and then any other non-inactivated process of the new crown vaccine is used when the subsequent strengthening injection is needed, then it is called "sequential enhanced immunization".

Who can carry out sequential booster immunization?

According to the unified requirements of the state, sequential enhanced immunization can be implemented in people over 18 years old who have been vaccinated with the inactivated COVID-19 vaccine of Sinopharm Zhongsheng Beijing, Kexing Zhongwei and Zhongsheng Wuhan for 6 months and have not completed homologous enhanced immunization.

Can older adults undergo sequential booster immunization?

People over the age of 60 who meet the requirements for sequential booster immunization may choose to have a sequential booster.

Is the SEQUENTIAL BOOSTER VACCINE FREE?

Implement a free vaccination policy for the sequential strengthening of immunization. People who meet the requirements for sequential booster immunization can choose one of the recombinant protein vaccines or adenovirus vector vaccines, and 1 dose of booster vaccination is free of charge.

Can I still perform sequential immunization after I have been vaccinated with booster injections?

Homologous booster immunization and sequential booster immunization should not be received at the same time.

The Omiljung variant has become the dominant strain of the mainland epidemic

The mainland has deployed vaccine research and development units

Carried out vaccine research and development of the Omi kerong variant

Today (February 19) afternoon, the joint prevention and control mechanism of the State Council held a press conference. At the meeting, Wu Liangyou, deputy director of the Disease Control Bureau of the National Health and Health Commission, said that the current Aomi Kerong variant strain has become the dominant strain of the mainland imported from abroad and the local epidemic, its transmission force is stronger, the transmission speed is faster, and the risk of imported epidemics and local epidemics in the mainland has increased significantly.

Guo Yanhong, supervisor of the Medical Administration Bureau of the National Health Commission, introduced that through the epidemiological analysis of existing cases, the intergeneration spacing between cases of Omicron infection is on average 3 days, which is further shortened by about 4 days of the Derta variant, and the transmission capacity of the Omicron variant is about 2 times that of the Delta variant, and the transmission capacity is stronger. Symptoms of Omiljung infection are atypical and the transmission process is more insidious. Case classification is mainly mild and ordinary, and the symptoms are relatively mild, and the imaging changes in patients are atypical.

Shao Yiming, a member of the expert group of the vaccine research and development special class, introduced that according to the real-world research that has been carried out in the mainland, the full vaccination of the new crown vaccine in the mainland can significantly reduce the risk of pneumonia and severe disease caused by the Omicron variant, and strengthening immunization can not only reduce the risk of pneumonia and severe illness, but also reduce the breakthrough infection rate caused by the Aomi kerong variant to a certain extent.

On the other hand, in order to be prepared, the mainland has deployed vaccine research and development units to carry out vaccine research and development of the Aomi Kerong variant. First, the inactivated vaccine research of the Omikeron strain has been carried out, and the preclinical research has been completed, and the clinical trial declaration materials have been submitted to the drug evaluation center with relatively rapid progress; the second is to carry out the broad-spectrum or multivalent recombinant protein vaccine research for the Omikeron strain, and the faster progress has also submitted clinical trial declaration data to the drug review center on a rolling basis; the third is to carry out the research and development of the adenovirus vector vaccine and nucleic acid vaccine for the Omiljung strain, and the animal efficacy and safety experiments have been completed with rapid progress, and are preparing to declare clinical trials Fourth, the relevant institutions have completed the guiding principles for the research and development and evaluation of vaccines of mutant strains, and issued them to vaccine research and development units from point to point.