On April 11, 2018, a workaholic collapsed in a position he loved. Found that his colleagues also thought that he was too tired from overtime, lying on the sofa to rest, but waited for a long time but did not see him wake up, so that the colleague gradually felt that the situation was not right, after careful observation, he found that he had left.
This workaholic named Wang Yiping is an excellent party member and a "medicine god" with outstanding achievements. The drugs he developed have saved countless patients who are plagued by cardiovascular diseases, and have also made ancient Chinese medicine into modern medicine and have been recognized by the whole world.
Wang Yiping was only 55 years old when he left, and he had not yet reached the age of retirement. The newly developed drug has been recognized by many countries and is preparing for the next step of testing. And he was even more looking forward to developing more new drugs, which could benefit mankind and continue to promote Chinese medicine to the world, but his time stopped on that day.
At first, everyone thought that he often worked overtime obsessively because of the high load of operation, which led to sudden death, after all, such incidents also occur from time to time in today's fast-paced life. However, in the eyes of colleagues, although Wang Yiping is a workaholic, he also knows how to combine work and leisure, such as moving his home near the unit, and when he is tired or uncomfortable, he will lie on the sofa in the office to take a nap and recover his energy.
So what exactly ruthlessly took away Wang Yiping, who still had a lofty ambition?
Abandon medicine and medicine
The time goes back 30 years, when Wang Yiping was still a medical student and was preparing to pick up a scalpel and start his own path to medicine. But an unforgettable internship made him decide to revise the trajectory of his life.
A dying old man took his hand and said in his mouth: "The doctor saved me, I don't want to die." "But later I learned from the attending physician that this uncle had no cure because there was no medicine."
At that time, Wang Yiping felt very depressed, and he knew that he wanted to be a doctor to save people in the world, but there was no cure for diseases, so there was no way to save people. Think again, even if you become a world-famous divine doctor, the number of patients you can heal in your lifetime is also controlled to death by time.
How to use the limited time to save more people has become the direction of Wang Yiping's thinking. In the end, he made a bold decision to put aside his existing medical achievements and apply for a master's degree in pharmacology, and became a pharmacist from then on.
I am determined to devote my life's energy to pharmaceuticals, and to develop drugs that are the first choice for all clinicians as the biggest goal in life.
That year, Wang Yiping was only 25 years old, healthy and vigorous.
Speed up
In the blink of an eye, at the age of 30, Wang Yiping became the youngest research group leader of the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences. But the ruthless fate played a fatal joke with him, and he was proficient in pharmacology and suffered from Crohn's disease, which was difficult to cure at that time and even now.
This is a chronic disease that is afflicting and rare in the country. The main symptoms are abdominal pain, diarrhea, weight loss, the cause of the disease is still unclear, the feasible treatment plan is only to remove the lesion site, but there is also a great probability of recurrence, the most important thing is that there is no drug to treat. Wang Yiping removed the 80 cm terminal ileum and the 20 cm ascending colon successively, but unfortunately the scalpel was not able to cut off the connection between him and the disease.
After fully understanding his illness, Wang Yiping decided: Since he could not drive it away, let's coexist with him. He prepared a brand new notepad to record his illness, in addition to relying on drugs to maintain, and never went to the doctor for his body.
Because life seemed to him to be limited, he often admonished himself:
"A person has about 30,000 days in his life, and only 10,000 days can be used to work. Do something meaningful in a limited amount of time."
Now that my body has advanced this countdown, it will take more energy to put into work.
So he turned on the full acceleration mode, spending most of the holidays on work, seven days a week, every day at least twelve hours in the laboratory to repeated experiments.
Modernization of Chinese medicine
At that time, Wang Yiping's research project was to crack the secret of danshen used to treat cardiovascular diseases, although the ancients discovered the efficacy of danshen, but for patients with critical cardiovascular diseases, the treatment process of decoction of traditional Chinese medicine is time-consuming and slow, and the clinical application is obviously impractical.
So how to integrate the wisdom of the ancients into modern medicine, so that these gifts of nature can be used more wonderfully? Find out the main medicinal ingredients in danshen and refine them, and then prescribe the right medicine in a way that is easier to absorb, so as to achieve the best efficacy, which is the goal that Wang Yiping wants to achieve.
Although what I say is very simple, in fact, it is not easy to develop a new drug, and the biomedical field has always been bound by the "double ten law", that is, "ten years of investment, one billion dollars" to develop a new drug. It can be seen that Wang Yiping's pharmaceutical road is still a long way to go, and the scientific research conditions at that time were not abundant, and the equipment and materials were shared by multiple research groups, which made the already difficult research even worse.
He often borrowed experimental equipment during the rest of other research groups, and then shut himself in the laboratory all night to study.
Fortunately, Wang Yiping is not alone in the battle, he met an important partner on the way to explore the mysteries of Danshen- Xuanli Jiang.
The process of developing new drugs can be described as quite boring, and it has undergone countless experiments to determine the active ingredient in danshen in the first step.
In 1994, Xuan Lijiang was studying for a doctorate at the Shanghai Institute of Medicine of the Chinese Academy of Sciences, and his research group was also involved in the research project of danshen. One day, Xuanlijiang sent some of the water-soluble ingredients of salvia isolated from his group to Wang Yiping for active screening.
They don't know how many times they've experienced the same thing, but this time they have unexpectedly made new discoveries, some active ingredients that have not been recorded before, and the long-awaited breakthrough has tied together two people who were originally just work intersections, and since then they have become friends, confidants, and even lifelong partners.
With the full cooperation of the two people, after repeated experiments of certification, magnesium salvia acetate with its super activity in thousands of sets of experimental data in the dust, stand out, basically can be identified as the most important medicinal ingredients in danshen. A new drug with magnesium salvia acetate as the quality control standard " salvia polyphenolate powder injection" was born. The next step is to confirm its efficacy through clinical trials, which will be a long process.
In the blink of an eye, 13 years have passed, and the new drug has "thrived" under the careful cultivation of the two people, and now it has grown into a "beautiful girl" who can proudly face the society. She also lived up to expectations, through repeated clinical trials to confirm that she has excellent efficacy on coronary heart disease, angina, so as to be recognized by the majority of patients, but also won the second prize of the National Technological Invention.
The secret of success
In this regard, although it has been medicinal for a hundred years, it does not know its reason, and finally has been unveiled a mysterious veil and has become a model for the modernization of traditional Chinese medicine in the mainland.
Until the moment of his death, danshen polyphenolate powder injection has been clinically applied in more than 5,000 hospitals across the country, with cumulative sales exceeding 25 billion yuan, benefiting more than 20 million patients.
In the eyes of their peers, their success is a complement of professionalism and luck. But only they know that success is made up of failure after failure, and there is no element of luck. When tens of thousands of failures are eliminated one by one, the rest will inevitably be closer to success.
Compared with luck, the spirit of "fighting another round" is the inevitable condition for their success, and this is Wang Yiping's consistent working attitude since he entered the pharmaceutical industry.
Selfless dedication
Wang Yiping is the "desperate three langs" in the research institute, which is well known in the institute. "Sleepy sleep on the sofa, sick to give yourself a needle, usually run to the toilet, do not like to drink much water." This is the daily life of Wang Yiping in the eyes of colleagues and students, they all know that he used to study medicine, thinking that he had a number in mind about his body, but he was in a hurry to produce results and desperately.
But a few more people know that he is really desperate. Sleep on the couch because you don't want to waste time on the way back and forth, and sometimes lie down because you can't stand up because of the pain. Painkillers and hormones are used to relieve the symptoms of Crohn's disease. His illness was destined to make him go to the toilet much more often than ordinary people, in order to reduce the number of diarrhea he drank as little water as possible, and thus got serious kidney stones, which aggravated the pain in the abdomen.
Most of the colleagues and students learned that wang Yiping had been tortured by illness for many years after his deeds were published. Looking back, when talking to him, he would suddenly crouch down for a while, or take a dip in the bathtub filled with hot water in the hotel for a long time while traveling, and at the same time realize with the students that it was trying to relieve the pain. It's all very touching.
If you change into an ordinary person, in the face of your own short life, you may think of trying to enjoy life, enjoy the world, and improve your material living standards. But Wang Yiping was an exception, and luxury was almost unrelated to him. His life is full of all kinds of old things, driving an old car for more than ten years, wearing a jacket for more than ten years, Nokia with seriously painted digital buttons, and the yellowed notepad, the only thing that makes him feel luxurious may be a can of black tea purchased online.
Wang Yiping's notepad recorded in detail his more serious illness each time. A palm-sized small book has been used for 25 years, nearly 200 written records, painful awakening, blood in the stool, blood in the urine, etc. appear frequently, and the more frequent it is, the colleagues who have read it are all touched by the tenacious spirit.
And Xuan Lijiang, who knew that he was sick earlier, was even more full of mixed tastes in his heart. When asked about Wang Yiping's life, he sighed: "I knew he had Crohn's disease, but I didn't know that he was so miserable. Before, I joked with him about cutting off 1 meter of intestines, and even advised him to drink, but now I really regret it. ”
Although it was just an unintentional joke between colleagues, why didn't Wang Yiping ever want to be able to eat meat and drink wine like an ordinary person? However, his physical condition did not allow it, and he also wanted to devote more energy to scientific research and develop more new drugs to save people who faced death due to lack of cure.
Who can cure Wang Yiping's illness? He knew very well that the cause of his Crohn's disease had not yet been ascertained and what drugs could cure it, it was nothing more than using hormones and painkillers to force it. A few months before his death, he already had a premonition that he would soon die.
Wang Yiping sorted out all his life's research into written materials and stored them in the two cabinets in the office, only for himself that he was no longer there, and someone could take the stick in his hand and continue to run. In his last few records of the condition, it can be found that the effect of the drug has become weaker and weaker, the painkiller needle can not hold the pain at all, and several times he feels that his life has come to an end.
But as long as Wang Yiping still has a breath, he still continues to plan what to do next, continues to pay attention to the progress of new drug research and development, and continues to record the process of his incurable disease for future generations to refer to, until March 26, 2018, the last disease record:
"Intermittent pain in the upper abdomen has occurred from time to time this year, and spastic pain has often occurred after lunch."
Leave quietly
Half a month later, Wang Yiping came to his office early as usual, but this time he never came out again. He collapsed on the couch he used to relieve pain, on the post he had promised in his life, and on the ground not far away there was an exhausted painkiller.
May there be no pain in heaven, and Wang Yi calmly left the world that he thought he had not yet dedicated enough. On April 21, the Shanghai Institute of Materia Medica held a memorial service for Wang Yiping. More than 700 people spontaneously came to bid him farewell, including his students, his colleagues, and his decades-old partners.
The meaning of life
Although Wang Yiping is no longer there, but his unfinished business will not be stranded, he developed a new drug "shuxinidine sulfate" can effectively fight arrhythmias, has completed the second phase of clinical trials, obtained the invention patent authorization in China, the United States, Germany, France, Switzerland, Italy and Japan and other countries, will benefit more people who are troubled by cardiovascular diseases, and the development of oral agents of salvia polyphenolates has also made breakthrough progress.
The persistent Wang Yiping does not care how long the lifeline is in a single dimension, but strives to make life more fulfilling and have greater energy in multiple dimensions. And there's no doubt about that, he did. He has saved countless living lives with his limited time, and he is the "medicine god" of this era.
On November 16, 2018, the Central Propaganda Department publicly released Wang Yiping's advanced deeds to the whole society and posthumously awarded him the title of "Model of the Times".