Many families who want to achieve a baby through the third generation of IVF are most reluctant to face the failure of IVF, what if IVF fails? After a failed IVF fertilization, many patients will fall into a sense of loss, and some will even be afraid of IVF and unwilling to try again.
In this regard, BeiLai fertility is hoping that families who choose IVF can understand that although IVF fertility has a remarkable effect, not everyone can succeed at once. If you fail once, don't be discouraged, you must first find the reason for the failure, in order to ensure the smooth progress of the next test tube.
You know, doing the third generation of IVF is not 100% successful, it will also be affected by many aspects, if the IVF fails, you must actively understand the reasons for the failure and how to avoid it next time. So what are the reasons for the failure of IVF?
First, the intimal factor
Intimal thickness is a commonly used clinical indicator to assess the quality of intimal membrane and the conditions required for transplantation. If the thickness of the inner membrane > 7-8 mm, it means that the quality of the intimal membrane is better, which is conducive to embryo implantation.
In addition to the thickness of the lining that can affect the outcome of the transfer, endometrial polyps and uterine cavity adhesions can also lead to embryo transfer failure.
Countermeasures: It is recommended that hysteroscopy be performed in families with repeated transplant failures. Hysteroscopy can find endometrial polyps and uterine adhesions, assess the severity of their condition, and at the same time remove endometrial polyps and isolate uterine adhesions.
Second, embryo quality and age factors
The success rate of the embryo transfer is directly related to the quality of the embryo itself, and if the embryo has quality problems and defects, it is also the possibility of failure of the transfer, such as abnormal chromosomal structure and other reasons. The older a woman gets, the fewer her eggs will be and the quality will decrease, which will inevitably affect the success rate of IVF. Among them, women aged between 25-35 years old have the highest IVF success rate, up to more than 45%; after the age of 35, their ovarian function and egg quality will have a more obvious decline, which leads to the success rate of IVF in women over 35 years old to about 26%-30%, and the success rate after the age of 40 is only about 20%-30%.
Countermeasures: Where couples have normal sexual life after marriage, do not use contraception, live together for 1 year and do not conceive are called infertility. Therefore, doctors recommend that infertile patients need to go to the hospital for infertility etiology screening as soon as possible, and carry out targeted treatment, choose appropriate assisted reproductive technology, and solve fertility problems as soon as possible.
3. Endocrine factors
Endocrine factors include abnormal thyroid function and hyperprolactinemia. Abnormal thyroid function, including hypothyroidism, hyperthyroidism, and abnormal increased activity of thyroid-related antibodies, are not conducive to embryo transfer.
Countermeasures: Maintain a peaceful and optimistic attitude, adhere to exercise, eat a reasonable diet, supplement vitamins and high-protein foods reasonably, and work and rest regularly.
4. Coagulation function factors
Antiphospholipid antibody syndrome, abnormal coagulation factors, etc. can easily lead to local microthrombosis, and insufficient local blood supply to the endometrium, which is not conducive to embryo transfer.
Countermeasures: Preventive interventions and regulatory therapy by injecting or taking drugs under the guidance of a doctor.
Fifth, immune factors
During embryo implantation, the immune function of the mother is abnormal, such as abnormal increase in the activity of natural killer cells, abnormal secretion of local immune antibodies, etc., which may be related to repeated implant failure.
Countermeasures: Treatment can be performed by intravenous infusion of immunoglobulins, increasing the success rate of IVF.
6. Chromosomal factors
Many early spontaneous abortions, some embryo implantation failures, is actually a kind of "survival of the fittest" in nature. Some patients learn after examination that there are indeed abnormalities in chromosomes or embryonic chromosomes.
Countermeasures: To solve the fertility problem caused by chromosomal abnormalities, the only way to use technology to screen embryos is IVF PGD technology. Embryos can also be screened, and healthy embryos without any diseases can be selected and artificially implanted into the uterus.
Seven, mentality, dietary factors
After transplantation, we must pay attention to the daily diet, because there is no good eating habits and the impact on the body, it is easy to affect the transplant results, in front of the test tube must control their emotions, if too worried and nervous, resulting in abnormalities will also lead to test tube failure.
Countermeasures: It is very important to relieve the patient's mental and psychological pressure, strengthen the full communication and communication between doctors and patients, and mutual understanding and encouragement between the husband and wife.
In fact, to do the third generation of IVF, one is to meet its conditions, and the other is to be fully prepared. Otherwise, if you take the risk of losing it, it is also an empty bamboo basket to hit the water. Because the success rate of the third generation of IVF is affected by many factors, any problem in any link will lead to failure, so it must not be ignored.