Roche translocation is the full name of the chromosome Robertson translocation, also known as filament fusion. It is a special form of mutual translocation of chromosomes, when two proximal centromere chromosomes are broken at or near the centromere, the long arms of the two are joined together at the centromere to form a derived chromosome composed of long arms, and the two broken arms constitute a small chromosome, which is often lost at the second division. It is named after being discovered by Robertson in 1916.
Is Roche translocation genetic?
Roche translocation is hereditary, its incidence in the population is 1, 23/1000, and it accounts for about 2% to 3% of infertility. This particular chromosomal weight row occurs mainly on chromosomes 13, 14, 15, 21, and 22, and carriers usually have 45 chromosomes, however, since the missing part is the short-arm heterochromatin part of the chromosome, most patients are phenotypes normal, but the vast majority of Roche translocations occur during the meiotic process of egg or sperm production, which can easily lead to offspring being Roche translocation carriers.
What are the causes of Roche translocations?
1. New mutations: If the embryo is affected by the outside world during the developmental stage, there may be chromosomal ectopic problems.
2, parental genetics: if one or both parents are Roche translocation carriers, then the child may also have chromosomal abnormalities, Roche ectopic if married to a normal person, theoretically produce a completely normal chromosome probability of embryonic probability of 1/6. Roche translocation also carries an embryo with a 1 in 6 probability. The remaining 4/6 probability is a chromosomal imbalance embryo.
Can Roche translocations produce healthy babies through three generations of IVF?
The answer is yes. If Roche translocation is found, the best thing to do is to choose to do a third-generation IVF. At present, the third generation of IVF PGS/PGD preimplantation gene screening technology effectively screens out embryos with abnormal chromosomal abnormalities, removes these unhealthy embryos, and only transfers embryos without chromosomal abnormalities, so as to achieve the purpose of eugenics.