82-year-old Grandpa Xia (pseudonym)
Sick for half a year,
Frequent fever due to lung infections,
Antibiotics are used to "use nothing",
What people didn't expect was that
Life-saving clues,
It was hidden in the TV series that my wife had watched!
The 82-year-old was infected with multi-drug-resistant bacteria
In June 2021, the 82-year-old Grandpa Xia accidentally choked on a meal, and the family did not pay attention to it. But since then, he has been unable to eat and has been lying in bed all day without getting up.
Ms. Xia, the daughter, said that her father was diagnosed with Alzheimer's disease two years ago and could not express exactly where she was uncomfortable. Three days after losing his appetite, Grandpa Xia was taken by Ms. Xia to a nearby hospital, where Grandpa Xia was diagnosed with aspiration pneumonia. At this time, his sputum was thick and thick, and he had begun to have a fever.
Grandpa Xia's treatment process can be described as a twist and turn. While suctioning and extracting tissue through bronchoscopy, he had tracheal bleeding, oxygen saturation was as low as 30%, and he was immediately intubated and rescued, and then transferred to the ICU for treatment for a week.
After coming out of the ICU, misfortune struck again. Grandpa Xia's sputum and alveolar lavage fluid were cultivated with multidrug-resistant Acinetobacter baumannii, multidrug-resistant Pseudomonas aeruginosa, and multidrug-resistant Staphylococcus aureus golden subspecies.
Multidrug-resistant bacteria refer to the results of drug-resistant bacteria, bacterial mutations and excessive use of antibacterial drugs in 3 or more classes of clinical use. Patients infected with multidrug-resistant bacteria will have much less room to do so than those infected with common bacteria.
A coincidence of fate! The TV series watched by the wife has become a "life-saving clue"
Just when Ms. Xia was worried about her father's illness, her mother said to Ms. Xia: "I recently watched a TV series, the male protagonist was infected with the drug-resistant Bowman like your father, and the female protagonist cured him with bacteriophages. ”
For Ms. Xia, as long as she can save her father, any method is worth trying. She immediately searched for information, consulted experts, and finally thought it was a reliable therapy. "My mother never watches a drama, and this time it really seems like a coincidence of fate." Ms. Xia said.
Unfortunately, the only hospital in China at that time that could perform phage cocktail therapy was the Shanghai Public Health Clinical Center, and Grandpa Xia was too thin and weak to support the distance from Shenzhen to Shanghai after a long period of gastric tube feeding and bed rest.
It took 600,000 antibiotics to be used without medication available
Unable to come to Shanghai to see a doctor, coupled with the fact that Grandpa Xia still has room for medication, Ms. Xia chose conservative treatment. However, the "superbugs" are too stubborn, and the level of antibiotics used by Grandpa Xia has been improved one level at a time, but he has never been able to completely kill them, and in the end, the antibiotics used alone will cost more than 4,000 yuan a day.
Ms. Xia did not think about transferring, but she believes that "all the medicines that can be used have been used, even if they are transferred to other general hospitals, there are no bacteriophages, and my father is not saved." ”
Fortunately, at this time, the "fateful coincidence" came again! She saw on the Internet that Professor Lu Hongzhou, the expert of phage cocktail therapy who wanted to take her father to see, and the secretary of the Party Committee of shanghai public health clinical center, came to shenzhen Third People's Hospital to become the president!
After Lu Hongzhou began to go out of the clinic, Ms. Xia hung up a specialist number. After evaluation, Lu Hongzhou believed that Grandpa Xia met the indications for phage cocktail therapy and could be transferred to the hospital for treatment. In the week before the end of 2021, Grandpa Xia was transferred from the hospital where he had lived for half a year to the Respiratory Medicine Department of the Third Hospital of Shenzhen. At this time, his physical condition is already very bad, in order to treat him, Ms. Xia's family has spent more than 600,000 yuan, of which more than 200,000 yuan is paid at their own expense.
What is the sacred phage that makes Ms. Xia so persistent? Kong Yingjun, director of the Department of Respiratory Medicine of the Third Hospital of Shenzhen, introduced that bacteriophage is a virus that invades bacteria, does not invade other organisms, including humans, and is generally used for multi-drug resistant and widely resistant bacteria. The phage was discovered in 1917 and first applied to the clinic, and shortly thereafter, broad-spectrum antibiotics were introduced, and phages that could only strike bacteria "one-on-one" precision failed to spread.
After Grandpa Xia was admitted to the hospital, the Shenzhen Third Hospital isolated and cultivated the strain, handed it over to the Shenzhen Institute of Advanced Technology to find and amplify the bacteriophage, and applied it to Grandpa Xia for the first time on December 31, 2021. Ms. Xia said: "The most obvious change is that after 3 days of using the phage, my father's phlegm became thinner. About the 10th of this month, the inflammation index declined; on the chest x-ray taken on the 11th, the lung inflammation has been controlled. ”
At present, Grandpa Xia is recovering well,
The amount of sputum is already very small.
Lu Hongzhou said,
In the future, it will continue to be carried out in the three hospitals in Shenzhen
New technology for bacteriophage cocktail therapy,
Benefit more patients.
(Guangzhou Daily)