The Lancet series of journals has been committed to publishing high-quality clinical scientific research. COVID-19 is a key word in 2021, but what other topics are you focusing on? We have selected 10 WeChat articles in the 2021 Lancet series of periodicals with high reading volume in addition to COVID-19 to share with you.
1
A global study published in The Lancet Oncology showed that 4% of all new cancers in 2020 may be related to alcohol consumption, with men accounting for more than three-quarters of them. The study estimated that 77% (568,700) of alcohol-related cancer cases were males and 23% (172,600) were females, with the highest number of cases of esophageal, liver and breast cancers. It is estimated that dangerous drinking and heavy drinking lead to the highest number of cancer cases, but the number of cancer cases caused by moderate alcohol consumption (about two drinks a day) is also estimated to exceed 103,000 in 2020, accounting for nearly one-seventh of all alcohol-related cases. The proportion of alcohol-related new cancers in all emerging cancers varies widely across different regions of the world, with North Africa and West Asia being lowest and East Asia and Central and Eastern Europe being highest. The authors call for public awareness of the carcinogenesis of alcohol and increased government intervention to reduce alcohol intake in areas most affected by alcohol consumption.
2
The Lancet Psychiatry published "Epidemiological Status of Depressive Disorder Prevalence and Health Service Utilization in China," led by Professor Huang Yueqin of Peking University Sixth Hospital. This study, part of the China Mental Health Survey from 2012 to 2015, aims to provide socio-economic factors associated with depressive disorders and the status of health service utilization for depressive disorders. The distribution of depressive disorders in China is characterized by a higher prevalence among women than men, a higher prevalence of the unemployed than the employed, and a higher rate of separation, widowhood or divorce than those who are married or cohabiting. Most people with depressive disorders have social dysfunction. Depressive disorders have low utilization of health services and low rates of adequate treatment. National plans are needed to increase the availability, accessibility and acceptability of health resources to facilitate the use of health services for people with depressive disorders.
3
A study published in The Lancet confirmed that cervical cancer rates were 87 percent lower in women vaccinated against human papillomavirus (HPV) at age 12-13 than in previous generations who were not vaccinated. The study estimates that by June 2019, there will be about 450 fewer cervical cancer cases than expected and about 17,200 fewer cases of severe precancerous lesions (CIN3) of the neck compared to unvaccinated populations. The study provides the first direct evidence of the use of bivalent vaccines to prevent cervical cancer worldwide. The authors note that it is hoped that these new results will encourage people to get vaccinated, as the success of vaccination programs depends not only on the efficacy of vaccines, but also on the proportion of people who are vaccinated.
4
The Lancet published a report on changes in BMI indices and obesity trends in rural and urban areas of China, led by the Center for Chronic Diseases of the Chinese Center for Disease Control and Prevention. The study found that the growth rate of China's adult body mass index has slowed down, but it has shown a more diversified trend, especially urban-rural differences and gender differences, which puts forward new requirements and goals for the formulation of future prevention and control strategies. Study results: First, between 2004 and 2018, the average BMI of Chinese adults showed an overall upward trend, but after 2010, the growth rate of average BMI of Chinese adults has slowed down, and the average BMI growth rate is half of the growth rate from 2004 to 2010. Similarly, the annual increase in overweight and obesity rates after 2010 was slightly lower than before 2010. Second, between 2004 and 2018, men's average BMI, overweight rates, and obesity rates all grew faster than women's. Third, since 2010, the average BMI, overweight rate and obesity prevalence of adult men and women in urban areas of China have slowed down; the average BMI, overweight rate and obesity prevalence of men in rural China have risen slightly lower than in urban areas, but this continues to maintain a steady upward trend among women in rural China. Fourth, the number of obese adults aged 18 to 69 in China in 2018 was about 85 million, of which about 48 million were men and about 37 million were women. In fifteen years, the number of obese people has increased by about 3 times. Fifth, among women, the average BMI of highly educated adults has been lower than that of low-educated people, and as the number of years of schooling increases, the rate of overweight and obesity decreases, but the opposite is true for men.
5
The Lancet's first global study of the impact of the COVID-19 pandemic on mental health shows that major depressive disorder and anxiety disorders worldwide increased by more than a quarter in 2020 as a result of the COVID-19 pandemic. In 2020, women and young people are most affected by depression and anxiety disorders. In the countries hardest hit by the pandemic in 2020, cases of depression and anxiety disorders increased the most. The authors call on governments and policymakers to take urgent action to strengthen the global mental health system to meet the growing demand for (mental health services) due to the pandemic.
6
The Lancet Infectious Diseases published a study by Professor Zhan Siyan's research group at peking university school of public health and Bian Jiaming, director of the Seventh Medical Center of the PLA General Hospital. The study, which analyzed 170 million outpatient prescriptions, is currently the largest outpatient antimicrobial prescription study in China. The results show that the outpatient antibacterial drug prescription rate in China's second- and third-level hospitals is about 11%, which is significantly lower than the standard of no more than 20% of the outpatient antibacterial drug prescription rate and no more than 40% of the emergency antibacterial drug prescription rate required by the 2011-2013 antibacterial special rectification activities. At the same time, the study also found that about 51% of the outpatient antibacterial drug prescriptions in China's second- and third-level hospitals still lack adequate drug indications, which is significantly higher than that of developed countries in Europe and the United States, but comparable to the level of Japan. The study also analyzes the use of antimicrobial drugs diagnosed by some common diseases, which provides a reference for further antimicrobial management plans and the formulation of measures to promote rational drug use in outpatient clinics in the future.
7
The Lancet Public Health publishes the results of an analysis of the risk and burden of cardia and non-cardia gastric cancers associated with Helicobacter pylori infection in China in collaboration with the University of Oxford, Peking University, the Chinese Academy of Medical Sciences and the International Health Organization's Cancer Research Center. This study shows that Helicobacter pylori infection increases the risk of non-cardia gastric cancer by 6 times and from cardia gastric cancer by 3 times. These relative risk estimates are twice as high as previous estimates in a study of Chinese adults. This study's estimate of the risk and burden of gastric cancer caused by Helicobacter pylori infection will help improve global burden of disease estimates and policymakers develop and implement local and globally adapted cancer prevention strategies. Combined with evidence from recent randomized controlled trials on the effect of radical H. pylori therapy on gastric cancer risk in China, this study recommends that population-based H. pylori screening and eradication should be considered as a key strategy for gastric cancer prevention in China and other high-risk countries prior to large-scale gastric cancer screening with barium fluorescent photography or endoscopy.
8
A study published in The Lancet showed that antihypertensive drugs prevented the development of severe cardiovascular disease, and found that drug treatment was effective in reducing the risk of cardiovascular adverse events in adults regardless of whether participants had a history of cardiovascular disease at the beginning of the study and their initial blood pressure levels. The authors say this is not to say that everyone must start medication, and whether or not to do it will depend on the patient's own cardiovascular risk factors, the likelihood of side effects, and the patient's choice. The authors call for changes to international clinical guidelines to make antihypertensive drugs available to all people at high risk of cardiovascular disease, regardless of their current blood pressure.
9
The Lancet Healthy Longevity published a study by Professor Wang Weiqing, director of the Department of Endocrinology at Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, on the spectrum of age-specific risk factors for diabetes in China. Studies have shown that metabolic risk factors contribute the most to diabetes risk at all ages, and as we age, the contribution of lifestyle risk factors to diabetes risk increases, especially unhealthy sleep. The authors emphasize that risk factors that contribute more to diabetes at different ages should be prioritized for effective prevention and management.
10
The Lancet Gastroenterology & Hepatology publishes the latest research by Professor Qin Renyi's team of Director of the Cholecreatic Surgery Center of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. The conclusion of the study suggests that for surgeons who cross the learning curve, laparoscopic pancreatic duodenectomy has certain advantages over open pancreatic duodenectomy, but the advantages are not as great as expected. Further research should focus on how to navigate the learning curve and explore which patients are more beneficial for laparoscopic pancreatic duodenal resection.
Chinese translations are for reference only, and all content is based on the original English text.