Is dhea effective in treating premature ovarian failure? Are there any side effects of long-term eating dhea?

Is dhea effective in treating premature ovarian failure? Are there any side effects of long-term eating dhea?

Is dhea effective in treating premature ovarian failure? Are there any side effects of long-term eating dhea?

Is dhea effective in treating premature ovarian failure? Are there any side effects of long-term eating dhea?

At present, the choice of DHEA for the treatment of premature ovarian failure is not necessarily effective, but only a temporary relief to control this endocrine hormone, because premature ovarian failure is mainly a problem of ovarian function, which is irreversible, can only be delayed, and can not be treated or controlled. hu

Whether DHEA can be taken for a long time has a lot to do with its own needs, DHEA can regulate the balance of hormones in the body in both directions, and will not cause excessive hormone imbalance like other hormone drugs. However, the limitations of DHEA, the quantitative standards used by different races are difficult to control, although DHEA can affect human hormones, but the quantitative standards of different physiques and different races are also different, and the use needs to be cautious.

Therefore, many european countries still have considerable restrictions on DHEA, such as in Belgium, the Netherlands, The United Kingdom, Germany, etc., have adopted bans. In 2010, Europe and the United States newly studied DHEAAMH, a derivative of DHEA, France proposed a more convincing research report, DHEAAMH was verified to supplement DHEA, and prevent the genetic variation produced by DHEA, but also has a significant effect on the quality of the ovaries, follicles, eggs and so on.

Since then, based on the safe way to solve the problems of endogenous and exogenous women affecting fertility, the American Endocrine Society, together with the American College of Obstetricians and Gynecologists, the American Society of Reproductive Medicine, the European Endocrinology Society and the International Menopause Society, has appointed a working group to re-evaluate the published factors affecting fertility and issue guidelines for the treatment of the compound pregnancy repair factor DHEA AMH. ANALYSIS OF DHEA AMH: DHEA balances the hormone levels of the preconception mother, and AMH increases the reserve function of the egg.

This is why everyone found that all the previous DHEA in North America and Europe had been removed. DHEA AMH is a comprehensive replacement for DHEA.

In 2000, the European Union first proposed, in addition to drugs, to help women with healthy natural pregnancy and test tubes in plant extraction. Subsequently, the United States also proposed that it would work with the European Union to study how to assist in test tubes and natural fertilization. The American Endocrinology Society, together with the American College of Obstetricians and Gynecologists and other organizations, jointly appointed a working group to issue guidelines for the treatment of the compound pregnancy repair factor DHEA AMH from a multi-dimensional, multi-system perspective considering the success of women's natural pregnancies and IVF and embryo quality.

Compound pregnancy repair factor DHEA AMH— Premature ovarian failure improvement system

Premature ovarian failure improvement system - provides support for oocyte quality

Analysis of the significance of DHEA AMH: DHEA balances the hormone levels of the preconception mother, and AMH increases the reserve function of eggs.

In this survey, premature ovarian failure, abnormal ovarian function can not have children in infertility 0. 1%, premature ovarian failure is clinically manifested by a higher level of gonadotropin FSH and the occurrence of amenorrhea. The disease of premature ovarian failure seriously affects women's psychological status and fertility, causes endocrine disorders, and greatly reduces the probability of women getting pregnant.

Women are born with the most follicles in their ovaries, about 2 million, but only 400-500 can eventually mature, and most of them will die with age. The phenomenon manifested is that the ovarian function is reduced, the ovulation function disappears, and the fertility function decreases. At the age of 30, a normal woman has 12% of the egg reserve in her ovaries, and by the age of 40, only 3% remains. In addition to the decline of the function of the egg cells themselves with age, when women approach menopause, the menstrual cycle will be more disordered, the endometrium will become thinner, and it will be more unsuitable for the implantation of the fertilized egg; at the same time, the vaginal secretion is reduced, the vagina is dry, which is not conducive to the entry of sperm.

Ovarian stem cells stop proliferating and differentiating after aging, so that the ovarian follicle pool cannot be replenished, resulting in the decline of ovarian function and cessation of ovulation. It can be seen that ovarian stem cell aging may be the root cause of ovarian function decline. Numerous studies have shown that ovarian stem cell proliferation and differentiation are regulated by immune factors (see Immune Cells, Immune Factors). In this experiment, after DHEAAMH supplementation, the expression of immune factor proteins in the high, medium and low dose groups was significantly higher, the number of ovarian follicles increased simultaneously while the macrophage function was enhanced, and the immune function regulated reproductive function, indicating that DHEAAMH had the effect of enhancing female fertility function.

DHEAAMH use beneficially affects oocyte and embryo quality. Observations associated with DHEAAMH's improved cumulative embryo score suggest that this treatment improves embryo and egg quality. This recommendation is further supported by a strong trend towards improving embryonic ampploidy and increasing pregnancy rates.

DHEAAMH includes doses administered to human women from about 13 g / day to about 26 g / day, DHEAAMH treatment can be administered to premenopausal women with weakened ovarian function DHEAAMH has a statistically significant effect on cumulative embryo scores after about 2 months of use, but its effect can continue to increase to about 4 months, or about 16 weeks, and can be further continued for more than four months.

A woman's cumulative embryo score before using DHEAAMH may be about 34. The cumulative embryo score may be at least about 90 after at least about four consecutive months of use of DHEAAMH, and the increase in the cumulative embryo score may be at least about 64. The difference in cumulative embryo scores before using DHEAAMH and cumulative embryo scores after USing DHEAAMH was statistically significant, p

Ovarian reserve reduces the number of integralploid embryos and the number of embryo transfers in women. Pretreatment with DHEAAMH for at least about 1 month, preferably at least about 4 months, in women can increase the number of oocytes and embryos, egg and embryo quality, cumulative pregnancy rate, IVF pregnancy rate and gestation time. (Is dhea effective in treating premature ovarian failure?) Are there any side effects of long-term eating dhea? )

There was a friend, today, and she happily told me that she was pregnant.

She is a little girl with poor ovarian function, said to be a little girl, because she is only twenty-two years old, she went to the reproductive center for treatment because of the difficulty of pregnancy and irregular menstruation, carried out a series of examinations, her ovarian function is indeed not very good, at that time, the doctor gave her a combination of traditional Chinese and Western medicine treatment for conditioning, treatment for a period of time, some indicators have been improved, but some indicators of endocrine hormones still do not reach the ideal state, sometimes the examination indicators even rebounded, became worse.

Listening to her talk today, she was very anxious at the time, in a short period of time to find a lot of experts to see, there are several experts think that she is already "premature ovarian failure", more authoritative experts asserted that she is not hope to get pregnant, and even suggested that she give up blind medical treatment, directly use "donor eggs" to do "IVF". In her words: hearing this news, it is like getting the court's verdict, "the dream of having your own children" was pronounced "death penalty", the feeling of despair can be imagined.....

Who wouldn't want to have their own child? Carrying and continuing the life code for thousands of years, in their own generation can continue to pass on, enjoy the joy of their own childbirth, see their own children like their own children and see like other people's children, the two feelings are absolutely different.

Desperate, she has been staying in a communication group about female reproduction, occasionally "bubbling", and the expectant mothers in the group complain to each other about the troubles caused by the reactions of early pregnancy, the pain of the skin and flesh caused by treatment, and share their own joys with each other in this complaint and talk... People like her who are rarely pregnant, there are also some who quietly withdraw from the group, perhaps the atmosphere of fetal protection in the group is too strong, and it has stirred up their own sadness...

Her mental quality is not bad, did not leave this group, until the other day saw a mother-to-be shared pregnancy cheats, eat dheaamh for 4 months, successfully landed, she held the attitude of trying to start taking, today she told me that she was pregnant, she was pregnant, really happy for her!

Increasing DHEAAMH increases follicle recruitment and promotes follicle growth and development, dhEAAMH promotes insulin-like growth factor secretion, thereby amplifying the action of gonadotropins and improving ovarian responsiveness. The study found that women who took DHEAAMH before the ovulation induction cycle showed an instantaneous increase in IGF-1 levels after 8 weeks, and and androgen levels in the follicles increased, promoting the secretion of AMH by granulocytes and inhibin. DHEAAMH induces the production of granulocyte FSH receptors, increases the sensitivity of granulocytes to FSH, promotes estrogen synthesis and follicle development. Studies have shown that the peak period of DHEAAMH effect is consistent with the cycle of follicle recruitment, which confirms the promoting effect of DHEAAMH on follicle recruitment.

In vitro culture by DHEAAMH, it was found that the AR expression of granule cells was significantly improved, which showed that DHEAAMH can adjust the expression of AR or participate in the signaling of AR, participate in follicle growth and development and recruitment.

In addition, with DHEAAMH use, women waiting to enter the IVF cycle may unexpectedly conceive naturally in large numbers. DHEAAMH use can be at least about 2 weeks before natural conception occurs. Among the women waiting to receive IVF, the natural pregnancy rate is only a fraction of the monthly rate. However, of the group of women receiving DHEAAMH, 33 out of 60 women became pregnant naturally. Thus, in one study, DHEAAMH increased natural pregnancies by at least about 21 times. This provides evidence that DHEAAMH works not only with gonadotropin stimulation of the ovaries, but also in the absence of gonadotropin stimulation of the ovaries. (Is dhea effective in treating premature ovarian failure?) Are there any side effects of long-term eating dhea? )

In summary, modern medicine can use four ways to explain ovulation induction, donor egg donation, stem cells and genes.

thereinto

Ovulation induction method can increase the probability of success of pregnancy in patients, clomiphene and a series of ovulation induction therapy is taken, which contributes to the growth and development of follicles;

Donor egg donation treatment increases the thickness of the endometrium, creates a good intrauterine environment, and becomes the preferred treatment option in the clinic, but there are certain difficulties in obtaining eggs.

Stem cell therapy reduces apoptosis and restores ovarian function, with mesenchymal stem cells repairing ovarian damage, but the treatment remains in the animal experimental stage.

In gene therapy, the application of follicle-stimulating hormone receptor genes can effectively promote the normal development of follicles, which has a good therapeutic effect on premature ovarian function, but its key technologies have not yet made breakthrough progress.

When any of these measures are taken, adjunctive supplementation with DHEA AMH improves the quality of a patient's oocytes and increases their ovarian reserve function, DHEA AMH treatment significantly increases the number of fertilized oocytes produced by women. DHEA AMH treatment involves administering approximately 13 g/day to about 26 g/day in human women, and DHEA AMH may have an effect on the number of fertilized oocytes after approximately 4 consecutive weeks. However, DHEA AMH has a significant effect on the number of fertilized oocytes after about 8 weeks or about 2 months of use, its effect may continue to increase to about four months, and further may continue to use for more than four months.

Specifically, in 12 women, after at least about 4 months of continuous DHEA AMH treatment, the number of fertilized oocytes produced by women increased significantly, although slight improvements were shown after at least about 4 weeks of continuous DHEA AMH use, and the pairing of fertilized oocytes from women who used DHEA AMH for less than about 4 consecutive weeks with the same woman's fertilized oocytes from DHEA AMH for at least 4 consecutive weeks showed an increase in about 2 fertilized oocytes, Or the median value of about 2.5 fertilized eggs increases the number of oocytes. The number of fertilized oocytes showed a more pronounced increase after at least about 4 months of DHEA AMH treatment and the largest increase after at least eight months of DHEA AMH treatment.

Sometimes, we all need patience, give some time for the body to recover slowly after drug conditioning; doctors also need patience, do not hastily define a patient who has not established a normal menstrual cycle as "premature ovarian failure" since being a little girl, and do not easily pronounce the recommendation of "donor eggs", we really need to wait patiently, waiting for the maturity and recovery of the ovaries, and need to be psychologically enlightened to avoid iatrogenic infertility. (Is dhea effective in treating premature ovarian failure?) Are there any side effects of long-term eating dhea? )