Delayed pregnancy preparations, uterus? oviduct? Will something go wrong elsewhere in your body? There are also many sisters who are infertile due to advanced age. Speaking of which, we have to say that the impact of age on women's fertility is actually very large.
When a woman reaches a certain age, the function of the ovaries declines sharply after the age of 35. Therefore, for some elderly women, improving egg quality has become an important mission.
The use of certain drugs can effectively improve the quality of eggs to a certain extent. For elderly women, it is likely that growth hormone will be needed when trying to conceive or doing IVF.
I believe that everyone does not know so much about growth hormone. Growth hormone is actually a polypeptide hormone, which is secreted by the anterior lobe of the pituitary gland, and its main function is to regulate the upward development of vertebrates, through the muscles, bones, ovaries and other target organs. Growth hormone has a very important regulatory effect on ovarian function.
Eggs are released from follicles, which are the basic units of female reproductive biology, and if the follicles are poorly developed, they will affect the quality of the eggs released, thereby increasing the difficulty of conception. Even if a fertilized egg is formed, the chance of miscarriage or stillbirth increases. During the development and growth of follicles, growth hormone can act on them.
Therefore, for women with low ovarian function, it can actually be treated with growth hormone.
Proper use of growth hormone has these benefits for follicles!
1. Participate in the early recruitment of follicles;
2. Promote granule cell proliferation and expression of Gn receptors;
3. Improve the mitochondrial function of oocytes and improve the quality of oocytes;
4. Promote the expression of endometrial receptivity-related marker factors and improve endometrial receptivity.
In addition, when doing IVF, the use of growth hormone in the process of promoting excretion can improve the pregnancy rate and embryo implantation rate.
Many families who come to do IVF have low ovarian function. Therefore, some doctors will recommend the use of growth hormone therapy.
So what do you need to pay attention to in the process of using growth hormone therapy?
The administration is mainly by subcutaneous injection, but also by intrauterine perfusion. Timing of application, previously used simultaneously with ovulation induction drugs when initiating ovulation induction. But now most centers are starting to favor pre-ovulation pre-ovulation with long courses, because the weeks or even months before the ovulation induction cycle are the GH-sensitive phase of small sinus follicles, and a larger, higher-quality group of follicles is prepared before entering the ovulation induction phase, thereby increasing the number and quality of eggs. In the latest clinical trials, researchers have begun to try to initiate GH pretreatment at least 6 weeks before the start of ovulation induction to maximize the improvement of egg quality and improve clinical outcomes.