We all know that the success rate of IVF is not 100%. After a TUBE transplant, some people can succeed, but some people will face failure. If the implant fails, you need to wait for the next IVF transplant. So, what are the reasons for the failure of an IVF transplant? Today, Xiaobian will take stock of the top ten reasons for test tube transplantation failure.
1. Uterine environmental problems.
Inadequate endometrial tolerance is also a major cause of transplant failure. Endometrial thickness, intrauterine mass lesions, chronic endometritis, endometrial immune microenvironment, etc. May affect the tolerance of the endometrium. If the endometrium is not thick enough, the embryo often fails to implant. If the thickness of the endometrium is too thick or too thin, it is not conducive to embryo implantation, which ultimately leads to IVF failure; embryo transfer failure is associated with a decrease in the ability of the endometrium to accept embryos. If the endometrium does not accept embryos, it will lead to the failure of the transfer;
2. Endocrine abnormalities.
Uterine contractions after embryo transfer may leave the embryo in a free state after implantation or implantation. Therefore, luteal support is required to strengthen endometrial function and prevent ectopic pregnancy and miscarriage. If your own endocrine level does not meet the requirements, it is likely that the embryo will not implant after the transfer.
3. Embryo quality problems.
Poor sperm or egg quality (e.g., chromosomal abnormalities, etc.) After binding into fertilized eggs, the quality is poor, the developmental potential is low, the vitality is weak, and the implantation ability is poor. If transferred to a woman's uterus, there is a good chance that the embryo will not implant.
4. Embryonic chromosomal abnormalities.
Chromosomes are carriers of genetic material and are an important factor in determining embryonic development. In embryos cultured in vitro, the incidence of chromosomal abnormalities can reach 30-40%, and these chromosomally abnormal embryos tend to be indistinguishable in appearance from normal embryos. As a result, many of the seemingly high-quality embryos may actually be accompanied by chromosomal abnormalities.
5. Doctor technique.
IVF is a complex and precise technique that includes early check-up, planning, ovulation induction, egg retrieval, sperm retrieval, IVF-ova binding, embryo transfer, and other steps. Every link is important, and improper operation can affect the ultimate success. Therefore, the hardware equipment of the hospital and the doctor's technology can affect the transplant results. Therefore, patients should try their best to choose a hospital with professional qualifications within their own conditions, good hardware equipment and good technical and experienced doctors. If multiple transplants are unsuccessful but the cause cannot be found, it is recommended to change the hospital and doctor to try.
6. Psychological stress.
Many patients worry that the embryos will not implant after receiving an embryo transfer, so they will feel uneasy and be in a state of nervous tension all day long. Chronic anxiety. Restless psychology can lead to endocrine disorders that affect embryo implantation.
7. Post-transplant maintenance.
After the transfer, women should also pay more attention to avoid the embryos from being implanted because of inadequate protection. Dietary attention should be taken to avoid spicy and cold foods, which will affect the environment in which the embryo implants. In addition, the interior is not breathable. Manual labor, constipation and diarrhea are all factors that affect implantation. Therefore, special attention must be paid after embryo transfer.
8. Hydrosalpinx.
The hydrosalpinx contains a variety of inflammatory toxic substances that will wash away, drown, and poison the newly transferred embryos, greatly reducing the chances of embryo planting. Therefore, before the embryo transfer, if there is such a fallopian tube problem, it is recommended to treat it before the transfer so as not to affect the implantation.
9. Immune factors.
If the mother's immune mechanism is abnormal, resulting in the rejection of the embryo by the endometrium, there is an abnormal increase in the activity of systemic or local natural killer cells, which may be toxic to the embryo and hinder planting. Abnormalities in immune mechanisms can be treated with intravenous immunoglobulins or fatty milk.
10. Abnormal coagulation.
Embryo implantation depends on the blood supply to the endometrium, which is inadequate, and thrombosis of small blood vessels in the placenta can lead to a decrease in the chance of embryo implantation or an increased risk of miscarriage.
Summary: The above is a detailed introduction to the top ten reasons for IVF transplant failure. There must be a reason behind every tube failure. Be sure to pay attention to targeted symptomatic treatment, do not give up easily, and be fully prepared to welcome your IVF baby.