Fructose, the name, sounds tall. Natural fructose, mainly found in fruits and honey. With the addition of fructose, it is widely used in beverages and food. In recent years, the total consumption of fructose has increased by 2 times, parallel to the phenomenon that the proportion of overweight and obesity has also risen sharply. This phenomenon has aroused great concern among scientists. The study found that the metabolic pathway of fructose is associated with obesity and tumor growth, and revealed the exact mechanisms in it, originally, because fructose changes the structure of the intestine. Let's now interpret the main points of the relevant research.
An important early conclusion about the health effects of fructose was that studies showed that fructose intake may cause brain changes that lead to overeating. For example, yale university research found that drinks with more fructose promote insulin resistance. Because glucose intake causes a decrease in the activity of the hypothalamus and striatum, these areas play a role in regulating appetite and reward mechanisms, and through functional linkage, increase satiety. However, fructose does not have such an effect, because fructose can not pass through the blood-brain barrier, therefore, ingestion of fructose, will silently increase the risk of obesity.
Scholars at the St. Lux Heart Institute found that about 40 percent of U.S. adults have some degree of insulin resistance, and artificial added sugar, especially fructose, increases these people's risk of diabetes and leads to worsening of the condition. Fructose, which is more potent than other carbohydrates, increases insulin resistance. Therefore, the World Health Organization recommends that calories from added sugars should not exceed 10% of the total calories per day, and it is best to control it below 5%. Specifically, men consume no more than 36 grams of added sugar per day and women no more than 24 grams. In addition, studies have also found that excess fructose can lead to increased triacylglycerol synthesis, resulting in accumulation of body fat. Therefore, people with elevated blood sugar levels should have a daily fruit intake of less than 200 grams.
After years of research, the team at Well Cornell School of Medicine in the United States finally confirmed the relevant mechanism of fructose causing obesity and tumor growth, and the paper of this study was published in the journal Nature. Studies have shown that fructose is transported by the type 5 glucose transporter GLUT5 in the epithelium of the small intestine and is phosphorylated, forming fructose phosphate, and accumulates within cells. The main metabolite of fructose, can increase the survival rate of intestinal epithelial cells, promote the growth of intestinal villi, thereby absorbing more nutrients and increasing body weight.
The team at The Well Cornell School of Medicine also found in earlier studies that increasing dietary fructose intake causes tumor volume in mouse models of colorectal cancer to increase, blocking fructose metabolism and inhibiting the progression of tumor growth. The latest research has found that the fructose diet will cause a significant increase in the length of the intestinal villi in mice, and lead to an increase in serum triglyceride levels, while the increase in the length of villi will lead to an increase in lipid absorption, fat accumulation, and weight gain, which are caused by increased cell survival.
Small intestinal villi, is present in the small intestine inside the elongated hair-like structure, villi can expand the area of the intestinal surface, promote food digestion and nutrient absorption, the result is to lead to fat accumulation and weight gain, if there is already a tumor in the body, it will promote the growth of tumors through related metabolic pathways, after all, tumor tissue also needs nutrition. The research team also found that under hypoxia conditions, fructose, the metabolite of fructose, inhibits the activity of pyruvate kinase, increases the survival rate of intestinal epithelial cells, and thus increases the length of villi. Reactivation of pyruvate kinase, reducing the increase in the length of intestinal villi, can inhibit tumor growth.
The conclusions of these studies suggest that by shortening the villi of the intestine, the absorption of fat can be reduced, thereby controlling body weight, and new targets can be found for the treatment of intestinal tumors. Ordinary people should realize that milk tea, juice, cake, and biscuits may bring temporary happiness, but the end result is to lead to obesity, and if there is a tumor in the body, the addition of fructose will promote tumor growth. I hope that the conclusions of scientific research can make everyone wake up, change their life behavior as soon as possible, and control the intake of added fructose.
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Your health, my concern. Professionals observe health from a scientific and humanistic perspective, including a series of express reports, details, reminders, doubts, observations, opinions, historical stories, etc., with the content of the original works of the author Wei Hongling and the team. All forms of misappropriation and reproduction without permission will be refused, otherwise they will be prosecuted in accordance with relevant laws.