Pingping is 35 years old this year, because she was busy with work when she was young, she thought that her work and life were stable and reached a certain level before considering having children, which dragged on to the age of 30.
Last year, Pingping and her husband began to prepare for pregnancy, but they have not been pregnant. She thought that she had never been pregnant, menstruation and everything were normal, the annual physical examination was fine, there was no reason why she couldn't get pregnant. Under the reminder of my girlfriend, I went to the hospital for the first time for a check-up.
Last week, Pingping went to the doctor with her examination report and asked the doctor how to prepare for pregnancy in her case.
Today we take a look at her pregnancy story.
Gynecological examination showed that Pingping was basically normal, the doctor suggested that she use B ultrasound to monitor ovulation, and the results of the three B ultrasound monitoring were as follows:
Pingping's ultrasound showed that on March 3, she had follicles that were close to maturity and could ovulate, but the urine test LH only showed weak positive, and the doctor considered letting her have sex that night. After the next day's monitoring, it was found that the follicles continued to grow. In this cycle of March, pingping's dominant follicle was not excreted, and the pregnancy preparation failed that month.
01. Only long and not row, mostly related to endocrine disorders
For Pingping's situation, her doctor analyzed it like this:
Nonovulation is the main cause of female infertility, and follicle development and ovulation are regulated by the hypothalamic-pituitary-ovarian gonadal axis, so many ovulation disorders are endocrine disorders of infertility.
There are many reasons for non-ovulation, some are follicular dysplasia, such as polycystic ovary syndrome, and some are follicular discharge disorders, such as pingping, which has a dominant follicle that grows but cannot rupture ovulation, most commonly in unruptured follicle flavinyl syndrome (LUFS).
Copyright: Guangzhou Wanfu Health Technology Co., Ltd
02. What is unruptured follicle flavinization?
Unruptured follicle flavinylation syndrome (LUFS) is when the follicle matures but does not rupture, the egg cells are not excreted and in situ flavinize, forming a corpus luteum and secreting progesterone, and a series of changes similar to the ovulation cycle occur in the body's effector organs.
LUFS often has no abnormal manifestations, patients have normal menstruation, biphasic basal body temperature, there is also secretory endometrium, in the luteal phase of blood progesterone (P) and estradiol (E2) levels and the normal ovulation cycle is not significantly different, only by consultation and general examination is no way to distinguish LUFS from the normal ovulation cycle.
For LUFS, it can be discovered by the following checks:
B-ultrasound examination
The follicles enlarge to 18 mm for 48 hours without rupturing, or the follicles do not collapse or disappear after 48 hours of HCG injection, but continue to grow.
Six items of sex hormones
On days 5-9 after the peak in LH, the serum P-value should > 31.8 nmol/L, and if the P-value is 9.54-31.8 nmol/L at this time, it is often indicative of lufs.
Depending on whether the follicle is mature or not, LUFS is divided into two types:
●MATURE FOLLICULAR LUFS: Refers to the fact that no peak LH is observed after the follicle diameter reaches the maturation standard, and the E2 level reaches 734pmol/L, P level
●Immature follicle type LUFS: refers to the follicle diameter is not up to standard, but the P-value has > 7.95 nmol/L.
Pingping's consultation and gynecological examination results are normal, only in the use of B ultrasound monitoring ovulation, only to find that the follicles can not be discharged, but because Pingping did not carry out sex hormone six tests, the doctor suggested that she in the next menstrual cycle, six sex hormone tests, to see LH, E2 and P value levels and changes.
03. Can I still get pregnant after follicle flavinization?
Normal women actually have 5%-7% of cycles of LUFS, so Pingping only did one B ultrasound monitoring is not enough to determine that LUFS caused her to be pregnant for 10 months without pregnancy. Pingping needs to be monitored continuously for several cycles and ruled out other possible diseases.
If it is indeed because of LUFS caused infertility, ovulation induction therapy is generally required, and pregnancy can be obtained after treatment. Clinically, western medicine can also use the method of combining ovulation promotion with traditional Chinese medicine conditioning.
If you are a patient with recurrent LUFS who has not been able to conceive after 3-4 cycles of multiple ovulation induction therapy, you may want to consider in vitro fertilization- embryo transfer (IVF).
For Pingping, the doctor's advice is also like this: after continuing to monitor ovulation, checking for sex hormones, and if LUFS is indeed present, it is recommended that she start ovulation induction therapy.
bibliography
Chen Linxin,Lin Qiufang. Research progress on unruptured follicular flavinylation syndrome[J].Massage and Rehabilitation Medicine,2019,10(01):53-54.