Pregnancy is a common thing between men and women, and pregnancy failure cannot all be attributed to women, but may also be related to men. Chromosomal abnormalities, poor lifestyle habits, sperm DNA damage, and advanced age can lead to pregnancy failure, so take a closer look at the causes.
What are the male factors for a wife's failure to conceive?
1. Micro-deletion of Y chromosome
Microdelexia of the Y chromosome is characterized by azoospermia, the absence of seminal cells, only support cells, accompanied by a shrinking testicular volume. Microdelecultures of the Y chromosome are prone to sexual chromosome instability, resulting in embryos being stopped or miscarried.
2. Chromosomal abnormalities
Abnormal number and structure of chromosomes will cause sperm meiosis disorders, affect sperm function, so that sperm cells apoptosis; there are abnormal sperm in the ejaculated semen, which can be combined with eggs after entering the body, which will lead to embryo suspension or miscarriage; abnormal chromosomal abnormalities after the split of the fertilized egg, resulting in pregnancy failure.
3. Infection
Infections with mycoplasma and chlamydia, or rubella virus and cytomegalovirus infections, can reduce sperm quality and lead to pregnancy failure in women.
4. Endocrine abnormalities
Abnormal adrenal function, thyroid gland, and gonadal abnormalities can disrupt hormone levels in the body, such as male hormone deficiency, estrogen levels are too high, resulting in the wife's failure to conceive.
5. Bad behavior habits
Men often wear tight pants, sauna or hot baths and other hot behaviors, long-term smoking and alcohol abuse, always stay up late, exposure to electromagnetic radiation, etc. can disrupt the endocrine system, damage reproductive health, leading to pregnancy failure.
6. Old age
Although men do not have spermatozoa, as they age, the quality of sperm becomes worse and worse, and they are prone to deformed sperm and weak sperm, increasing the risk of miscarriage and embryo infertility.
7. Sperm DNA is damaged
Mature sperm lack cytoplasm and have poor self-healing ability. But mature egg cells. DNA repair is better, can be repaired immediately after slight damage, and can still continue the pregnancy. Men who smoke and drink heavily, receive radiation therapy and chemotherapy, and varicocele can easily lead to serious damage to resting DNA, resulting in the miscarriage of wives or the cessation of embryos.
8. Abnormal epigenetics or modifications
Protamine integration into nuclear chromatin, methylation of DNA, and retention of directional histones will all affect sperm development. The role of sperm is not only to transport chromosomes, but also contains oocyte activation factors and centrosomes, as well as substances necessary for the development of a fertilized egg. Therefore, when there is an abnormality in epigenetics or modifications, it will affect the wife's pregnancy.
9. Genetic mutations
Base replacement can lead to changes in the type and sequence of amino acids in the polypeptide, resulting in a large number of abnormal protein molecules, thereby reducing the function of proteins; gene mutations can easily cause macrocephaly sperm malformations, which affects conception.
Tips
Wife pregnancy failure, repeated miscarriage, embryo suspension is greater than twice, then men should go to the hospital as soon as possible to do semen routine, infection indicator screening, to see what is the cause, as far as possible to maximize the natural success of pregnancy rate, to achieve eugenics. Men should adjust their living habits, choose loose and breathable underwear, maintain local cleaning and ventilation of the scrotum, avoid wearing tight pants, and reduce the number of saunas and hot baths. At the same time, moderate exercise should be maintained, drug abuse should be rejected, and adequate sleep should be ensured.
Family doctor online special article, unauthorized reproduction