Long-term eating statin, must be eaten with aspirin?
When popularizing common drugs for cardiovascular diseases, many netizens left messages to ask this question, we will first summarize the 3 answers -
Eating statin for a long time does not have to be paired with aspirin.
Statin and aspirin are good partners, and in some cases they are taken for a long time to help reduce cardiovascular risk.
Friends who have been eating statins and aspirin for a long time should understand the precautions for taking medication and better reduce the risk of medication safety.
Regarding these three aspects, we will introduce them to you in detail.
Long-term eating statin, must take aspirin?
Although there are many times when statins and aspirin are good partners, and these two drugs are also important basic drugs for the prevention of cardiovascular disease, long-term use of statins does not necessarily have to be paired with aspirin.
To make this clear, we must understand the specific role of these two drugs.
The main role of statins is to strengthen lipid control. This type of drug by inhibiting the synthesis of cholesterol in the liver, reduce the production of blood lipids, so as to achieve the effect of reducing blood lipids, in various types of blood lipid indicators, mainly on LDL cholesterol has a clear control effect, and LDL cholesterol is the primary goal of controlling cardiovascular diseases, therefore, statins are a class of basic drugs that control blood lipids and reduce cardiovascular risk.
The role of aspirin is to prevent blood clots. When the atherosclerotic plaque ruptures, the ruptured plaque in the blood vessel will also cause the aggregation of clotting substances such as platelets, and if these coagulation substances form "blood clots", it will block the blood vessels, causing myocardial infarction, cerebral infarction and other major problems, aspirin for cardiovascular aspects, mainly to play its role in inhibiting the production of thromboxane A2, thereby reducing platelet aggregation and reducing the risk of thrombosis.
In terms of mechanism of action, statins are mainly to strengthen blood lipid control and stabilize plaque, while aspirin is to prevent the risk of thrombosis caused by plaque rupture. If the blood lipids are high, bringing a higher cardiovascular risk, through life conditioning, blood lipids can not be controlled to the target level, you should consider taking statins to strengthen control; and if there is a high risk of thrombosis or secondary thrombosis risk, you can consider taking aspirin; and if it is a simple high blood lipid need to take statin, and have not had a cardiovascular disease, assess a higher risk of bleeding, or no higher risk of thrombosis, it is not necessary to take aspirin.
Statin and aspirin are good partners
The clinical reality is that many times, statins and aspirin need to be taken together, especially some friends with existing cardiovascular diseases, often need to strictly control blood lipid levels, but also to prevent the risk of thrombosis, in this case, such as no contraindications, need to be taken with aspirin, these two drugs are the basic drugs for the secondary prevention of cardiovascular disease.
For those who do not have cardiovascular disease problems, through the assessment of blood lipids, blood pressure, blood sugar, plus risk factors such as smoking, obesity, kidney health, etc., it is a high-risk risk, whether to eat statin and aspirin at the same time, it is necessary to divide the situation:
No cardiovascular disease, but high risk, blood lipid levels through life conditioning, low-density lipoprotein also fell below 2.6mmol / L, need to take statins to control blood lipids.
If there is a high risk of cardiovascular risk, there is a higher risk of gastrointestinal bleeding or other bleeding risks, and if this risk cannot be controlled, do not take aspirin to prevent blood clots.
Without cardiovascular disease, cardiovascular is at high risk, accompanied by hypertension problems, blood pressure control is less than 150mmHg or less, do not take aspirin.
Those who have a high-risk cardiovascular risk, but through active lifestyle therapy and medication, can reduce the cardiovascular risk to a low- and medium-risk risk, do not have to take aspirin.
Long-term eating statins and aspirin, 5 precautions to understand
As mentioned earlier, for existing cardiovascular diseases, blood lipids need to be strictly controlled, and the need to control the risk of thrombosis, aspirin and statin with taking, is a very common combination, if you take these two drugs for a long time, understand a corresponding precaution, it is particularly important, today focus on 5 aspects.
1. Pay attention to the reasonable choice of drugs
There are many kinds of statins, reasonable choice is very important, such as renal insufficiency, optional atorvastatin, the elderly, can preferably resuvastatin, there is muscle pain, friends with elevated blood sugar risk, can consider not through liver metabolism, low risk of blood sugar pravastatin and so on.
The use of aspirin in the prevention of blood clots, the choice of low dose (about 100 mg) of enteric-coated tablets is the best, low dose and enteric solubility can help reduce the risk of adverse drug reactions.
2. Pay attention to the time of taking the drug
For the problem of taking the drug time, it is also worth noting.
Simvastatin, pravastatin and other short-acting drugs, it is more reasonable to take at night, simvastatin is generally recommended to take after dinner, and pravastatin can be considered before bedtime, and if it is atorvastatin, rosuvastatin and other long-acting statins, choose a fixed time to take it every day.
The time of taking aspirin enteric-coated tablets should be maintained on an empty stomach, and taking it on an empty stomach can make the drug quickly pass through the stomach into the intestine, reduce the disintegration of the stomach, thereby reducing the stimulation of the gastric mucosa. Regarding the question of taking it before going to bed or taking it in the morning, you can choose it according to the situation, without too much entanglement, such as friends who need to take statin late, and eat it with aspirin.
3. Pay attention to monitoring the effectiveness of drugs
The effectiveness of aspirin is difficult to evaluate through simple clinical examination indicators, but for statins, we must pay attention to regularly check blood lipids, we must understand our own blood lipid control goals, for friends who have cardiovascular diseases, LDL cholesterol levels should be reduced to at least 1.8 or less to be safe, regular examination to know whether blood lipid control standards, if not up to standard, should be adjusted in time to adjust the medication plan.
4. Pay attention to life conditioning
Taking medicine is only a means, not the ultimate goal, nor is it the only way to control cardiovascular risk, taking drugs is to reduce risk, and want to comprehensively reduce risk, actively do a good job in life conditioning intervention, long-term maintenance of a healthy lifestyle is an important basic prevention aspect, therefore, while adhering to medication, in life should also do a good job of scientific and reasonable diet, adhere to exercise and exercise, maintain a peaceful state of mind, quit smoking and alcohol, maintain adequate sleep and other aspects of conditioning, only from the two aspects of life and drug prevention are done well, In order to better reduce cardiovascular risk and reduce the probability of secondary attacks of cardiovascular disease.
5. Pay attention to drug risk control
Many friends are too worried about the risk of medication, in fact, it is not necessary, as long as they take active action, understand the possible drug safety problems, and actively control through usual attention, regular examination and other means, long-term use of aspirin and statin, the risk of drug safety problems is actually not high.
Statin drugs should pay attention to the main drug risks include elevated transaminases, muscle pain, long-term medication blood glucose increases, etc., regular or timely liver function, creatine kinase, blood glucose and other indicators of the examination, combined with the change of relevant indicators, timely discontinuation or adjustment of the medication regimen, and actively seek solutions, in most cases, long-term use of statins, can achieve safe medication.
The main risk of aspirin is the risk of bleeding, aspirin can inhibit platelet aggregation to prevent thrombosis, and at the same time this antiplatelet effect, will also bring about an increase in the risk of bleeding, especially the risk of gastrointestinal bleeding, it is worth paying special attention to, for friends with a high risk of gastrointestinal bleeding, when taking aspirin, you can pay attention to taking gastric mucosal protective agents (such as pazole, famotidine, etc.) for a period of time to reduce the risk of bleeding during taking the drug. In addition to the risk of gastrointestinal bleeding, the risks of subcutaneous hemorrhage and cerebral hemorrhage that aspirin may bring are also worth noting.
Having said so much, in fact, in the final analysis, it is still the problem of rational and safe use of drugs, the so-called rational and safe use of drugs, that is, the use of drugs in a timely manner, the use of drugs should not be used indiscriminately, during the use of drugs, actively understand the effectiveness of the drug, and pay attention to the risk of possible adverse reactions, do a good job in inspection and prevention, these aspects are done well, the safety and effectiveness of the drug will be more secure, and our health will be more secure.