When the 93-year-old richest man on Hong Kong Island was still struggling overseas to find life-prolonging life technologies and spending trillions of dollars on it, Chinese scientists used grape seeds to find "natural senescent cell scavengers", extending the survival period by more than 64%, surprising the entire scientific community.
1. Chinese scientists use "grape seeds" to break down industry obstacles
On December 7, the authoritative journal Nature published joint scientific research results from the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences, buck aging institute, Mayo Clinic and other top scientific research institutions in the world, they found a substance called PPC1 from a specific grape seed, which can "accurately remove senescent cells", prolong the survival of organisms by 64.2%, and found no obvious side effects.
According to the experiment leader, the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences, the removal of senescent cells has always been considered by the scientific community to be one of the most promising means, but in the past, the removal accuracy was not high enough, and it will hurt normal cells, so it has not been landed for many years. In order to break through this obstacle, the team studied for a long time, roughly screened nearly a thousand substances, and then screened from the library of 46 natural raw materials of plants on a large scale, and finally discovered the utility of PCC1.
Firstly, the application of PCC1 in mice with tumors was explored. When PCC1 is used alone in tumor mice, it can only maintain the status quo of the tumor; but when PCC1 is used with chemotherapy drugs, the tumor volume is about 55.2% smaller than that of the previous drug alone, which is precisely because PCC1 clears the senescent cells and improves the drug environment.
When PCC1 was used in healthy mice, the life growth effect was very significant. After the research team gave nearly 100 24-month-old experimental animals (equivalent to 75 years old) PCC1, their maximum pace, grip strength and other external performance were improved, and the survival period was extended by 64.2%! It is worth mentioning that even if the experimental animals are exposed to strong radiation, strong magnetic fields and other strong intervention environments, PCC1 can still increase their survival time.
2． Not the usual "grape seed extract"
This achievement has been called an "industry milestone" by the industry, to know that before that, can extend the survival of more than 60% of the substances are rare, even the most important "dasatinib + quercetin" combination, only 36%, but also there are not enough to remove accurate, damage to healthy cells side effects.
In fact, people are no strangers to "grape seed extract" and think that there is no shortage of related supplements on the market, so it is not surprising that this discovery is not surprising. In this regard, researchers responded: In the past, people studied grape seeds from the perspectives of antioxidant, anti-inflammatory, and cardiovascular protection. But this study is the first to demonstrate its effect on anti-aging.
And PCC1 is also very different from the previous grape seed rough extract mixture, only a specific source, a specific batch of grape seeds can be extracted, and the relevant raw material suppliers have also applied for patent technology, is a veritable cutting-edge technology.
However, the researchers also said that at present, PCC1 has only succeeded in animal experiments, and there are still some levels to pass, and it will take a long time to land. It is understood that the domestic professional anti-aging science popularization institution "Time Pie" built by Fudan University doctor is the first batch to pay attention to PCC1 research, and has also reached cooperation with raw material suppliers, and may be recruited to try in the near future.
Researchers at the Harvard P.G Center for Aging Biology said that before pcc1 landed, there were also methods such as "Cylery" that were mass-produced. Although the 28% survival extension trial was less effective than PCC1, it was also supported by a series of trials such as the University of Tokyo, Tongji, King's College London and Swiss Polytechnic. In addition, due to the reduction of the technical threshold, "Cylery" is no longer the exclusive use of the rich in the past, and has entered the range of thousands of yuan, which is easily available in channels such as Beijing-East International.
3. Face the billions of investments of rich businessmen?
In recent years, some rich people, especially the elderly, have attracted much attention, including the 93-year-old former richest man, who has also begun a large investment in the field of life science and technology.
But most of what he supports are overseas projects: supporting the University of California, Berkeley for $50 million (about 320 million yuan) for the crispr-cas9 gene compilation tool known as the "anti-aging" scientific research; and then investing 180 million Hong Kong dollars to support the research and development of anti-aging substances by the US company CDXC... Nowadays, domestic scientists have brought amazing life extension results, which is inevitable to be a bit of a slap in the face.
In addition, before the international anti-aging field, the leader is mostly foreign teams, domestic research started late, but the Chinese people's hard work spirit does not lose any country, the discovery of PCC1 is a strong proof of catching up, it is foreseeable that Chinese scientists will have more say in this field in the future.