When it comes to diabetes, for people who are not familiar with the disease, all that comes to mind is the simple symptoms of high blood sugar!
But for patients who have been diagnosed with diabetes, they are well aware of the bigger problems behind diabetes. It seems that it is just a blood glucose exceeding the standard, but once the blood glucose control is not good, as the patient's condition continues to progress, complications may occur in the later stage. Relevant research and surveys have shown that there are more than 100 complications related to diabetes.
In about 10 years of onset of diabetes, 30 to 40% of patients will have at least one complication. The more patients the disease is poorly controlled, the more likely they are to develop complications.
Moreover, once diabetic complications arise, it is difficult to achieve reversal with drug treatment. For example, kidney damage caused by diabetes will eventually develop into kidney failure and uremia.
Therefore, it is of great significance to prevent the emergence of diabetic nephropathy, and if you want to prevent the disease, you must first understand its cause. In the clinical view, the following four reasons are the real culprits behind the emergence of sugar kidneys:
1. Poor blood sugar control
As mentioned above, any diabetes-related disease is actually based on high blood sugar. The less ideal the blood glucose control, the greater the likelihood of complications.
Relevant research investigations have shown that hyperglycemia and glycosylation end product production increase, resulting in mesangial cell proliferation, extracellular matrix increase, mesangial expansion, and eventually the emergence of chronic kidney disease. If the blood sugar control is good, it can significantly delay the development of sugar kidney;
2. Abnormal renal hemodynamics
Relevant research and investigation show that renal blood flow motility plays a key role in the occurrence of sugar kidney, and may even be the fundamental factor in its occurrence.
In the process of continuous increase in blood glucose, the glomeruli are in a state of hyperperfusion and high filtration, at this time, the patient's capillary wall pressure increases, which will lead to mesangial cell expansion, glomerular epithelial cells are damaged and shed from the basement membrane, under repeated injury, gradually develop into diffuse, nodular lesions, and the glomeruli slowly harden;
3. Hypertension
According to the data available to the clinic, hypertension is actually not directly related to the occurrence of diabetic nephropathy. However, if the patient already has hypertension, or if microalbuminuria occurs during the course of the disease, an increase in blood pressure can accelerate the progression of diabetic nephropathy, promote the deterioration of kidney function, and aggravate the symptoms of proteinuria.
That is to say, once diabetes mellitus is combined with hypertension, it will increase the likelihood of kidney disease and accelerate the development of kidney disease;
4. Genetic factors
In mainland China, some patients with good long-term blood glucose control eventually developed diabetic nephropathy. There are also relevant studies that have found that diabetic nephropathy has a family cluster, and in some diabetic patients with a family history of hypertension, the probability of diabetic kidneys is significantly higher than that of other patients without family history.
In addition, there is evidence that there is also a disparity in the incidence of diabetic nephropathy between different ethnic groups. Judging from the various evidences, the emergence of diabetic nephropathy may be related to genetic factors, that is, genes affect the prevalence of the next generation.
In a word, the emergence and development of diabetic nephropathy, like other diabetic complications, is the result of the combined action of multiple factors. But its most fundamental factor is actually the long-term poor control of blood sugar.
Therefore, in the clinical view, as long as it is a patient diagnosed with diabetes, it is necessary to actively cooperate with the doctor for treatment to reduce the possibility of complications.