A few days ago, the team of academician Jia Weiping of shanghai Sixth People's Hospital published a latest research result online in the authoritative journal "Diabetes Care" (impact factor 19.11) in the field of diabetes - for the first time reported that osteocalcin (OC) can predict the occurrence of diabetic kidneydisease (DKD).
The research paper was co-authored by Academician Jia Weiping's doctoral student Ye Xiaoqi, master's student Yu Rong and Dr. Jiang Fusong of Lingang Campus as co-first authors, and Hou Xuhong and Jia Weiping as co-corresponding authors.
Osteocalcin is not only involved in bone metabolism processes, but also as an endocrine hormone, involved in the regulation of the body's energy metabolism and sugar metabolism, and can affect insulin secretion function.
Previous studies have reported that OC may be associated with the risk of developing diabetes, but whether it has an impact on the development of chronic complications of diabetes is unclear. DKD is the most common chronic complication of diabetes, and renal failure can occur in advanced stages, which seriously endangers human health. Therefore, it is extremely important for the early prediction, diagnosis and timely treatment of DKD.
The study followed up the established Shanghai Lingang Nicheng Community Chronic Disease Prevention and Treatment Cohort for an average of 4.6 years to explore the relationship between OC and diabetes mellitus and the risk of DKD. 5396 participants without diabetes and 1174 participants with diabetes but without DKD were included.
The results found that participants with higher levels of OC had a lower risk of developing diabetes and DKD, while those with lower levels of OC had a significantly increased risk of developing diabetes and CKD. Studies have further found that the effects of OC on diabetes may be mediated in part by adiponectin. This study is the first prospective study in the world to explore the relationship between OC and the risk of DKD.
The research results provide new perspectives and new ideas for the pathogenesis and early prediction of diabetes mellitus and DKD, which have important clinical significance.
Source: Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital