BeiLai Fertility Center said that the follicle growth mature does not rupture, resulting in ivory tube egg retrieval failure, then, the follicle does not rupture there are various factors, clinically difficult to have accurate diagnostic evidence, treatment will vary from person to person.
Several cases in which follicles do not rupture during IVF
1. Women have ovulation disorders
Female ovulation disorders mainly occur in the case of pelvic inflammation, polycystic ovary syndrome, pelvic inflammation will cause female ovarian cortical hyperplasia, causing the follicles not to rupture; Pcosystic ovary syndrome will stimulate ovarian fiber hyperplasia due to luteinizing hormone and high androgen levels, and abnormal proliferation of ovarian white membrane can easily lead to follicle non-rupture.
2. Abnormal endocrine hormones
Follicles secrete a large amount of estrogen during development, and the larger the follicle, the greater the estrogen secretion, and when the excessive secretion of estrogen exceeds the normal value, it will stimulate the hypothalamus and pituitary gland to release LH, forming the ovulation peak of luteinizing hormone. Follicles can grow rapidly in this case, but they cannot rupture. In addition, the emergence of common diseases such as hyperprolactinemia, decline in ovarian reserve function, and polycystic ovary syndrome will affect the normal rupture of follicles.
3. Loss of enzymes in the body
The production of enzymes is also the result of the action of LH and FSH, LH deficiency affects the increase of CAMP, so that the activity of fibrin and plasminogen activators in the ovaries is low, which can reduce the plasminogen activity on the follicle cells before ovulation, affecting the lysis of fibrin and the self-action of the follicle wall. Proteolytic enzymes also play a role in follicle rupture, and when these enzymes are lacking, they cause the follicle to not rupture.
4. The effect of ovulation-promoting drugs
When the development of follicles, the maturity of follicles and the natural cycle are inconsistent with the natural cycle in the process of IVF stimulation, the drug will cause LH peaks to appear early, or LH peaks will not match the development of follicles, causing a high incidence of flavinization, and the incidence of follicle non-rupture syndrome is significantly higher than that of the natural cycle. For example, clomiphene (CC) can significantly increase the syndrome, and it is believed that drugs such as CC can cause ovarian matrix and follicular luteinization.
5. The influence of psychological state
Couples of childbearing age who are plagued by infertility are in a long-term emotional state of high tension, depression, and negativity, which will affect the endocrine disorders of the human body, and the level of prolactin in the blood will repeatedly appear small peaks, thus affecting the normal discharge of follicles or causing follicles not to rupture.