Ovulation induction is the most critical and important step in the entire IVF process, it is not only a science, but also an art, not only in the right quantity, but also in good quality. Some people will get more than 30 mature eggs, while others will only have a few eggs, so what factors affect the number of eggs obtained?
1. Aging factors
Women determine before birth how many egg cells they will have in their lifetime, and their quantity and quality decline with age. Ovarian reserve function begins to decline after the woman reaches the age of 35, resulting in a decrease in the number of sinus follicles, and egg quality is not easy to be optimistic even after multiple ovulation inductions. This is also the reason why it has always been advocated to do test tubes early.
2. Premature ovarian failure
Some women experience premature ovarian aging, resulting in fewer sinus follicles and fewer eggs for ovulation. It's like fishing, there are more fish in the pond, it's easy to catch, you can catch more, you can catch less; but if there are fewer fish in the pool, it's hard to catch, and it's impossible to catch a lot.
3. Low ovarian response
Sinus follicles respond poorly to exogenous follicle-stimulating growth hormone, are difficult to grow and mature, and can lead to fewer eggs being acquired.
4. Empty follicles
There is no problem with the number of sinus follicles, but the eggs in the follicles are missing. The number of follicles seen under B ultrasound and the number of obtained are not equal, such as the relationship between peanut shells and peanut grains, the follicles seen under B ultrasound are peanut shells, and the eggs obtained are peanut kernels, sometimes peanut shells look normal, but there may not be peanut grains in the middle. Among patients with low ovarian function, the number of eggs obtained will also be affected.
The eggs are invisible to the naked eye and need to be removed and microscopically examined under high magnification to be seen. Sometimes patients have uneven development of follicles after ovulation induction, and overripe follicles may have ovulated before egg retrieval, so empty follicles may occur. It's like an egg with only "egg whites" and no "yolks." After the egg retrieval, laboratory personnel were unable to find available eggs.