CCTV news: Vaccination may be a common experience for most people in 2021. Everyone gave "one arm" to build an immune barrier for everyone. Behind this health barrier is a vaccine industry chain that can serve more than a billion people. Today's "I Move Forward with the Country", we will meet the people who compete with the virus. This group of people is the closest to the new crown virus, in addition to fighting the virus, they also have to race against time to provide the richest and most perfect virus for vaccine research and development, so as to ensure the production and supply of new crown vaccines. They are the ones who helped us put on the armor of the new crown virus. Let's walk into Li Na's team, which is responsible for the development of inactivated vaccines, and see what unusual stories they have experienced this year.
At eight o'clock in the morning, there was a lively discussion in the conference room, and Li Na and her team were discussing a plan for an urgent task of the mutant poison strain, Aomi Kerong, and immediately after the meeting, she set off for the Chinese Center for Disease Control and Prevention.
Li Na, head of the quality of the new crown vaccine of Sinopharm Group: "Because of the recent outbreak of Aomi Kerong, we have just received a notice that we also have cases in China, and then got this sample." We're going to go to cdc right away and talk to CDC experts about this cross-neutralization option. ”
On the way, Li Na did not care to rest, and kept in touch with all parties on the issue of Aomi Kerong.
Four hours after the meeting, Li Na returned to the unit from the Chinese Center for Disease Control and Prevention, and then led the team members to the production workshop to inspect.
Li Na introduced to reporters in the production workshop: "This is our P3 new crown (inactivated vaccine production) No. 3 workshop. This workshop from scratch, from the beginning of the foundation to the completion and production, it took only 100 days. ”
Because the new coronavirus is highly contagious, the culture of live viruses needs to be carried out in a P3-level biosafety laboratory. The so-called P3 laboratory refers to a laboratory that is in a state of negative pressure and is completely sealed. This is also the daily work position of Li Na's team.
As one of the leaders of the research and development team of the new crown inactivated vaccine, Li Na's core team has a total of 12 people, with an average age of 32 years old. They are mainly responsible for the establishment of the new crown virus poison seed bank and the identification of the virus seed bank, which is one of the most core tasks in the research and development process of the new crown inactivated vaccine.
Guan Xixi, a new crown vaccine developer at Sinopharm Group: "The cells we usually cultivate viruses are called vero cells, and its form is a fusiform shape, you see it in this field of vision, normal round, fat, very beautiful, is a normal cell state we raise." After being exposed to the new crown virus, this cell will be completely destroyed by the virus, and then it will become round and wrinkled, there are empty holes, and it can be seen that it is not as beautiful and round as before, but these are the seeds of our vaccine. We collected these densely packed fragmented cells, which were then inactivated and purified to form our vaccine. ”
In 2020, the coronavirus has disrupted the entire world, and the world is pinning its hopes on vaccines. In order to develop the vaccine as soon as possible, researchers usually work in the P3 laboratory for several hours, during which time they cannot eat, drink or go to the toilet.
Li Na, head of the quality of the new crown vaccine of Sinopharm Group: "In the P3 environment, because we wear glasses and then wear P3 goggles, look at the microscope for three or four hours, especially our culture plate is a very small kind of hole, 96 holes, each hole to observe its lesions, to see this plaque, staring for three or four hours, after coming out the whole eye is very dry." ”
Guan Xixi, a new crown vaccine researcher at Sinopharm Group, said: "The biggest problem is still lack of oxygen, basically some colleagues have to take oxygen when they come out, and then the mental state is also very tired, but we have overcome these." ”
Even if the working environment is very uncomfortable and the mental pressure is also very high, Li Na and her team still stick to the front line of the development of the new crown vaccine. In their hearts, only by developing a vaccine earlier can we improve the impact of the epidemic on people as soon as possible.
Li Na, head of the quality of the new crown vaccine of Sinopharm Group, said: "The more I see the news so serious, the more I feel that we who make vaccines must hurry to the front line." A race against time is really a race against time. ”
Racing against time and using science to defeat the epidemic, this is the sentence that Li Na said the most in the interview. Usually, the development of a vaccine, from the screening of the virus to the preclinical animal experiment will go through a long time, in the past several experiments to undertake one by one to do. But the development of a covid-19 vaccine was imminent, so the R&D team changed the order of the past and carried out more than ten experiments at the same time, so that the intensity of daily work was doubled several times.
Li Na, head of the quality of the new crown vaccine of Sinopharm Group, said: "We have adopted a series change parallel approach, all experiments are carried out synchronously, a large number of data and results we analyze synchronously, and race against time." Sometimes the sample comes out, sent to the laboratory at two or three o'clock in the evening, our team of people are about to test, after the results of the whole research team also have to meet together, often at three or four o'clock in the morning, together to discuss today's batch of experiments out of this result. All 365 days are work, and basically everyone lives in the company. ”
After more than 100 days of hard work day and night, China has finally made significant progress in the research and development of inactivated vaccines. After completing phase III clinical trials, vaccination of high-risk groups began on July 23, 2020.
Li Na, head of covid-19 vaccine quality at Sinopharm Group, said: "I am very excited that the dream of putting on the armor of frontline medical staff has come true. ”
From the launch of the phase III clinical trial to the conditional approval of the new crown vaccine, it took only 168 days. On the evening of December 30, 2020, the State Food and Drug Administration approved the conditional listing of the inactivated covid-19 vaccine developed by Li Na's team in accordance with the law. On May 7, 2021, the World Health Organization added this inactivated vaccine to the emergency use list, the sixth COVID-19 vaccine to receive WHO certifications for safety, efficacy and quality.
The successful development of the COVID-19 inactivated vaccine has excited everyone on Li Na's team. However, their work is far from over and they continue to race against time. The cunning virus is constantly mutating, from last year's Alpha and Beta strains to Delta and the recently discovered Omiljung strain, every time the new coronavirus mutates, Li Na will lead the team to isolate the strain of the new virus.
Li Na, head of the quality of the new crown vaccine of Sinopharm Group, said: "It has always been this wartime state, waiting for orders at any time. As soon as there is a mutant, go back to the laboratory, repeat the preliminary work, and then re-study the nature of the mutant strain, as well as some manifestations of the virus. ”
For Li Na and her team, 2021 and 2020 have been running, and the pressure is also very high. The pressure in 2020 mainly comes from the need to develop a new crown vaccine as soon as possible, which is a process from scratch; while the pressure in 2021 mainly comes from two aspects, one is to deal with the constantly mutating virus, and the other is to ensure a steady supply of vaccine production.
Li Na, head of covid-19 vaccine quality at Sinopharm Group, said: "Before the new crown, the annual batch of vaccines issued in China was about 700 million, and then after the new crown, the monthly production volume of our company was 450 million, which is basically two months to produce the vaccine volume of the whole of China in one year." ”
Wartime speed, day and night. In order to ensure the steady supply of vaccines at home and abroad, on June 21, 2021, the world's largest COVID-19 vaccine production base was fully operational in China, taking only 98 days and with an annual production capacity of more than 5 billion doses.
Liu Jingzhen, chairman of Sinopharm Group, said: "We have built 3 P3 high-grade biosafety laboratories and 6 P3 high-grade biosecurity production workshops, which are also used as the national biosecurity strategic scientific and technological forces. ”
According to the latest data provided by the State Food and Drug Administration, as of December 15, 2021, the State Food and Drug Administration has approved the conditional listing of four new coronavirus vaccines, and urgently approved 27 vaccine varieties from 5 technical routes to enter clinical trials, actively promoting the inclusion of two new coronavirus vaccines in the World Health Organization's emergency use list and joining the implementation plan of new crown pneumonia vaccines. While vigorously promoting domestic vaccination, China has also provided 2 billion doses of COVID-19 vaccine to more than 120 countries and international organizations around the world, and more than 99% of the vaccines provided by China have arrived in developing countries.
Li Na, head of COVID-19 vaccine quality at Sinopharm Group, said: "What is the most gratifying moment for us, that is, how much the vaccination rate of our country has reached, and which country our vaccines can go to." To a certain extent, let everyone get rid of the biggest impact of the epidemic on everyone's entire life and work at the beginning, and we can get on track in some aspects, which I think is something we are very proud of. ”
Source: CCTV