Recently, the U.S. Department of Health and Human Services (HHS) released its 15th carcinogen report, in this new version of the carcinogen report, the relevant content has been further updated, and chronic infection caused by Helicobacter pylori is listed as a clear human carcinogen.
In this newly released carcinogen report, chronic infection caused by Helicobacter pylori is a clear carcinogenic risk, based on sufficient evidence of carcinogenicity in human and animal studies. Epidemiological investigation data show that Helicobacter pylori is the main culprit in the cause of non-cardia gastric cancer and lymphoid tissue lymphoma associated with gastric mucosa. Mechanistic studies have shown that Helicobacter pylori infection can cause cancer through biological pathways present in humans, while in animal experiments, Helicobacter pylori can cause adenocarcinoma and gastric lymphoma, similar to the type of cancer it causes in humans.
Statistics show that about 89% of non-cardia gastric cancers and more than 92% of gastric mucosal-associated tissue lymphomas are associated with Helicobacter pylori infection, which can cause 780,000 new cases (mainly stomach cancer) worldwide each year, accounting for about 6.2% of the total new cases of cancer worldwide.
Does Helicobacter pylori infection necessarily lead to stomach cancer? How can I eradicate Helicobacter pylori infection? In today's popular science article, I will introduce the relevant knowledge in this regard for you.
Is helicobacter pylori infection necessarily cancerous?
Although chronic infections caused by Helicobacter pylori, they have been listed as definitive human carcinogenic factors. But if you think that people with Helicobacter pylori infection will definitely suffer from stomach cancer, that is to scare themselves.
Infection caused by Helicobacter pylori is only a risk factor with carcinogenic effects, which means that people infected with Helicobacter pylori have a higher risk of stomach cancer than non-infected people, while people with obvious symptoms of Helicobacter pylori infection have a greater risk of cancer than asymptomatic people.
China is a big country infected with Helicobacter pylori, but there are many Helicobacter pylori infections are asymptomatic, whether the infected people will suffer from cancer, and the subtype of the strain infected Helicobacter pylori infection, the physical characteristics of the infected person, most of them have a close relationship.
In the report, it is pointed out that the significance of identifying carcinogens lies in determining the known or reasonably expected carcinogen substances or exposure environment, and whether a person will develop cancer is often closely related to a number of factors, including the carcinogenic efficacy of the substance, the level of exposure, the duration, and the individual's sensitivity to the carcinogenic effects of the substance, for example, people with impaired immune systems have a higher risk of cancer.
In addition, other studies have shown that in addition to Helicobacter pylori infection, diet, including factors such as high salt, processed foods, and red meat, may also increase the risk of cancer in infected people.
Therefore, for the problem of Helicobacter pylori infection, we must look at it rationally, do not care, nor should we worry about the sky, in addition to combining the situation, reasonable eradication of Helicobacter pylori infection, in daily life, improve autoimmunity, avoid the influence of some other carcinogenic factors, etc., is also very important.
How to eradicate Helicobacter pylori infection, it is important to grasp 3 key points
About 60% of adults in China have problems with Helicobacter pylori infection. Chronic infection caused by Helicobacter pylori is already a clear risk factor for cancer, so how should Helicobacter pylori infection be eradicated? Some friends take a lot of medicine, eradication is not successful, or eradication is successful but re-infected, how to avoid such a situation? Let's give you some dry goods.
For the eradication of Helicobacter pylori infection, quad therapy is currently a universal method, and two antibiotics, a gastric acid inhibitor and a bismuth agent can be selected to combine the drug to achieve the effect of eradicating Helicobacter pylori. In order to achieve the effect of complete eradication, rational use of drugs is the key, and rational use of drugs, there are many aspects -
1, the choice of drugs: antibiotics should try to choose drugs with low drug resistance rate, there are many regions, Helicobacter pylori to clarithromycin, metronidazole resistance rate is higher, levofloxacin resistance rate is also higher, therefore, in the first selection of drugs, usually can be less resistant to amoxicillin, plus a low rate of resistance to antibiotics, such as tetracycline, furazolidone, etc., of course, but also to comprehensively consider the drug contraindications and adverse reaction risks, gastric acid inhibitors usually choose pazolium drugs, Esomeprazole, rabeprazole, etc. with good gastric acid inhibition effect can be selected.
2, the reasonable choice of medication time: four drugs need to take four drugs, but in terms of medication time is also exquisite, usually two kinds of antibiotics are taken healthily after meals, while prazole drugs and bismuth citrate potassium and other bismuth agents should be taken half an hour before meals, such a time collocation, the effect will be more ideal.
3, dietary attention during taking drugs: during the medication, in addition to paying attention to the impact of drugs, you should also pay attention to the impact of diet and living habits, as far as possible should pay attention to a light diet, do not further stimulate the gastric mucosa, should strictly prohibit alcohol, avoid drinking alcohol to cause disulfiram reaction, life-threatening. At the same time, we must also pay attention to dietary hygiene, Helicobacter pylori can be transmitted through hand-mouth, fecal mouth and other ways, therefore, pay attention to frequent hand washing, while paying attention to moderate meal sharing, tableware special, the use of public chopsticks and spoons, etc., are good hygienic eating habits, help to strengthen the eradication rate of Helicobacter pylori.
If you can do the above 3 aspects, usually the probability of effective eradication of Helicobacter pylori is still relatively high, usually after a month of complete drug stoppage, you can go to C14 or C13 breath test review, if the review results are negative, it means that it has been eradicated successfully, after the eradication is successful, the same still pay attention to the diet, pay more attention to hygiene and protection, try to eat less to eat in restaurants with poor sanitary conditions, wash your hands before and after eating, divide meals moderately, pay attention to oral cleanliness and hygiene, both help to avoid the occurrence of secondary infections.
If the eradication is not complete, the review finds that Helicobacter pylori has not been successfully eradicated, and there is no need to be depressed or excessively worried, whether secondary eradication is needed, or should be considered in combination with the professional assessment of medicine, for asymptomatic infected people, it is not recommended to carry out repeated drug eradication, and for symptomatic infected people, especially patients with peptic ulcers, MALT lymphoma and other highly related diseases of Helicobacter pylori infection, it is recommended to carefully choose a drug regimen for secondary eradication and further eradication.
On the problem of Helicobacter pylori infection, we should understand its risk, do a good job of prevention and conditioning in daily life, if you find that you have been infected with Helicobacter pylori, do not have to panic too much, combined with the situation and personal wishes, you can reasonably use drugs to eradicate it, today's content, I hope to be able to understand and cure Helicobacter pylori infection for everyone, provide a little knowledge, we still have any problems or experience, also welcome to discuss and share together.