Like many people,
I've always dreamed of having a baby of my own.
But I wasn't so lucky.
Because
I am a systemic lupus erythematosus (SLE) patient.
SLE has always been known as "undead cancer",
It is also one of the rumored "killers" in the fertility world.
So
I always thought I could be this life
There's no way to be a mom.
But just now, I actually identified the "squadron leader"!
Just when I went to consult jianka with joy,
My sky has fallen...
The joy of pregnancy was instantly shrouded in deep despair
Because the doctor told me,
Taking medicine may have an effect on your child...
My dreams were shattered
But I'm not reconciled,
Pluck up the courage to find the medicine man,
I want to do the last struggle...
ask
Can someone with SLE get pregnant?
answer
The disease itself does not affect the patient's fertility, so it cannot be killed with a stick, and it is determined that female patients with SLE cannot get pregnant normally. But there are more places for SLE patients to be aware of when getting pregnant than the average woman. For example, some drugs for the treatment of SLE, such as cyclophosphamide, triptolide, etc., will indeed affect women's fertility; blindly stopping drugs in order to get pregnant is more likely to lead to adverse outcomes such as miscarriage and stillbirth.
What do people with SLE need to prepare if they want to get pregnant?
First of all, we must face up to the disease and actively treat it! Control the disease in a relatively stable quiescent period (usually more than 6 months). Some expectant mothers will be more anxious, SLE has not been well controlled to start trying to conceive, once pregnant, it is easy to worsen SLE and induce complications (such as miscarriage, premature birth, eclampsia, fetal SLE, etc.), exacerbating the risk of pregnancy of expectant mothers, and even life-threatening. Therefore, in addition to the basic preconception examination, SLE patients who want to become pregnant should also go to a specialist to assess the disease state at the time of pregnancy, whether there is damage to important organs, such as kidneys (the third trimester will increase the burden on the kidneys, accelerate renal dysfunction, and even lead to kidney failure), if lupus nephritis has been diagnosed, it is recommended to postpone pregnancy and control renal function to a reasonable range before trying to conceive.
Secondly, if the drug cannot be completely stopped before pregnancy, you must find a specialist to adjust the drug, choose a drug that is relatively safe during pregnancy, and do not stop the drug as soon as you find out that you are pregnant. Some SLE mothers-to-be blindly stop the drug because they are overly worried about the impact of the drug on the fetus, and they do not expect to cause the recurrence or deterioration of SLE during pregnancy, and finally have to terminate the pregnancy.
What are the drugs that are relatively safe for patients with SLE during pregnancy?
If SLE expectant mothers need to take medication during pregnancy, the drug with the highest current safety is hydroxychloroquine, followed by low-dose aspirin. The effects of hydroxychloroquine on mothers, mainly ototoxicity, retinal bleeding, or pigmentation, require active monitoring and prevention. For the fetus, although it is still shown in animal experiments that hydroxychloroquine will pass through the placenta, in the current limited clinical data, it cannot be shown that hydroxychloroquine directly causes fetal dysplasia. The most common effect of aspirin is bleeding, which can also lead to anemia in expectant mothers, prenatal or postnatal haemorrhage, pregnancy or prolonged labour. However, there are also no data to show a direct correlation between low-dose aspirin and fetal malformations. It must be emphasized that whether to use drugs or not, and which kind of drugs to use, need to be evaluated by specialists and pharmacists.
SLE is terrible,
But when mom is every woman's right,
SLE Mom is also exceptionally great.
Follow the doctor's advice, monitor diligently,
Greet new life with a relaxed and pleasant mood.
May every SLE mom achieve what she wants,
Have your own little treasure.
Author: Yang Jia, Department of Pharmacy, Chengdu Women and Children's Central Hospital
Audit expert: Liu Chuangyang, chief pharmacist of the Department of Pharmacy and Pharmacology of the Fourth Medical Center of the PLA General Hospital
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