"Good inflammation, how can you say that cancer is cancer?!"
Mr. Zhang is 63 years old this year, and when he was young, he developed the habit of never leaving his cigarette and drinking at the table. More than two years ago, because of nausea, I went to the hospital for a gastroscopy, and the results showed reflux esophagitis.
But Mr. Zhang was very confident in his body, and he was not at ease with the results, so he should smoke and smoke after taking some medicine, and he should drink and drink until he found that he could not swallow until recently, so he rushed to the hospital.
This time, the pathological results changed drastically, showing that the lesion developed into a poorly differentiated squamous cell carcinoma of the esophagus, invaded the tissues, and missed the optimal time for treatment.
1. Direct evidence: long-term inflammation may "contribute" to the occurrence of cancer
Inflammation is actually not far away, and it is possible for everyone to have inflammation in their bodies. Improper diet, stress, stress and other unhealthy lifestyles can lead to the production of various inflammatory factors, which may accumulate and induce chronic inflammation.
More and more studies have found that there is a relationship between chronic inflammation and the occurrence of cancer.
In July 2023, researchers from the University of Oxford published a study in Nature Genetics, which said that chronic inflammation is an important driver of leukemia, and also found direct evidence between inflammation and cancer, which is related to the TP53 gene.
Hematopoietic stem cells are the most susceptible to chronic inflammation, and researchers took advantage of this to induce artificial inflammation in mice through targeted sequencing technology, and found that the number of hematopoietic stem cells with TP53 mutations increased significantly, and they were more likely to develop into blood cancer cells.
TP53 mutations can be detected in many types of tumors, suggesting that chronic inflammation has a broad impact on cancer development.
Wang Bojun, chief physician of the Department of Gastroenterology at the Affiliated Hospital of Ningbo University School of Medicine, said that chronic inflammation is a long-term disease, and when the body's internal environment is under a low level of inflammation for a long time, it will have an adverse impact on the immune system. Over time, DNA damage may occur, leading to cancer.
Yu Huiqing, director of the Department of Geriatric Oncology at the Affiliated Cancer Hospital of Chongqing University, also reminded that chronic inflammation is generally not easy to detect, but the harm it brings is great. It is related to the occurrence of cancer, diabetes, cardiovascular and cerebrovascular diseases, etc., if you feel often tired, weak, and in poor condition, it may be that there is chronic inflammation in the body, so you should pay attention.
2. One-sixth cancer is related to inflammation, and there are 4 common types of cancer
More than 100 years ago, the father of German pathology, Rudolf . Vilshaw hypothesized that cancer originated from inflammation. After so many years of development, we now certainly know that there are many causes of cancer, but it is indeed inseparable from inflammation.
According to a report released by the International Center for Research on Cancer, about 1/6 of all cancers worldwide are related to bacterial/viral infections, which are commonly known as inflammation. More and more studies have also found that there is a relationship between inflammation and tumor metastasis, and these four types of inflammation are "reduced" as soon as possible.
1. Chronic gastritis
Non-atrophic gastritis can evolve into chronic atrophic gastritis after a long time, and if the disease is not intervened in time, there is a risk that it will evolve into gastric cancer.
2. Chronic enteritis
Chronic inflammation of the colorectal mucosa can cause bulging lesions of the mucosa, which are colorectal polyps and adenomas, and polyps are generally benign. Adenomas have a chance to evolve into cancer, so it is necessary to intervene in time once they are found.
3. Chronic pancreatitis
Acute pancreatitis can cause severe pain and can develop into chronic inflammation without standardized treatment. Repeated episodes of chronic pancreatitis can lead to a significant increase in the probability of cancer.
4. Chronic cervicitis
The occurrence of cervicitis is related to the invasion of pathogens such as childbirth, miscarriage and surgery, and not all patients with cervicitis will develop cancer. However, if you have cervicitis and have HPV infection, you must be very vigilant.
3. Diet is closely related to inflammation, and 5 foods should be eaten sparingly
In 2020, a 32-year study involving 210,000 subjects published in the Journal of the American College of Cardiology noted that food exacerbated or improved inflammation in the body.
In other words, the food we eat every day will have an impact on "inflammation", and some of the foods may promote the development of inflammation and further induce cancer. Xue Qingxin, a member of the Chinese Nutrition Society, said that according to the dietary inflammation index, the following five kinds are all pro-inflammatory foods, and they can eat less if they can.
1. Excessive red meat
The pork, beef and mutton we often eat are red meat, and excessive intake of such meat products will promote the body's inflammatory response, and will also increase the risk of colorectal cancer and obesity.
2. Processed meat
Bacon, ham, sausages, etc. are all processed meats, and these foods will produce polycyclic aromatic hydrocarbons and heterocyclic amines during the production process, and excessive intake will increase the body's oxidative stress level and easily produce inflammatory reactions.
3. High-carb foods
Delicate staple foods and foods with high sugar content contain a lot of carbohydrates, and excessive intake of such foods can stimulate the expression of inflammatory molecules in the body and increase the risk of inflammation.
4. High-salt, pickled food
Pickles, salted fish and other foods contain a lot of salt, and excessive intake is not only easy to induce high blood pressure, but also stimulates severe inflammation in the body and causes damage to the target organs.
5. Trans fatty acids
Chocolate, margarine cakes and creamer milk teas containing cocoa butter substitutes contain a lot of trans fatty acids, and excessive intake can promote inflammation and lead to obesity.
The impact of chronic inflammation on the body is subtle, if chronic inflammation is found in the body during the daily physical examination, it must be actively treated and treated as soon as possible.
Resources:
[1] "From "Inflammation" to "Cancer" There are only three steps! Doctor: Give the body "anti-inflammatory", do these 4 points! 》. Popular Science China 2023-09-25
[2] "These Inflammations Are Cancer Accomplices!" If you don't "reduce inflammation", it's dangerous". Zhejiang Provincial Cancer Hospital 2024-05-06
[3] "Eat back the "inflammation" that comes out! Put away this list of "anti-inflammatory" foods! 》. Health Times 2023-07-13
Reproduction without the author's permission is prohibited