"The new standard in the industry"
In the cosmetics industry, it is easy to follow the trend and enter the market, but it is even more difficult to expand the territory and lead the trend, and in the field of recombinant collagen, it is easy to "take it", but it is even more difficult to take root in research and development and achieve breakthroughs.
Although the road ahead is difficult, someone must open it up. Marubeni, which has been deeply involved in cosmetics research and development for more than 20 years, is gradually leading the in-depth application of recombinant collagen in the field of cosmetics as a leader and breakthrough.
Yesterday (April 27), the 4th Marubeni Recombinant Collagen Science Forum with the theme of "Collagen Core Growth" was successfully concluded in Guangzhou. At the forum, Marubeni not only launched the new recombinant collagen research and development results, officially announcing that the research and application of Marubeni's recombinant collagen has entered the 2.0 era, but also launched the formulation of the industry standard of "Recombinant Soluble Collagen" as one of the leaders of industry rules, and launched the "Recombinant Collagen High Quality Standard Initiative", handing over a successful "Marubeni answer sheet" to the industry.
Marubeni enters the era of collagen 2.0
As we age, the production of natural collagen in the human body decreases year by year, and the concentration of collagen in the reticuloderm decreases, which is one of the important reasons for the aging of human skin.
Bernard Mourieux, chief scientific advisor and chairman of the Academic Committee of Marubeni, academician of the French Academy of Sciences, and former president of the French National Academy of Sciences, mentioned that recombinant collagen integrates with the extracellular matrix, rebuilds the extracellular microenvironment, provides support for cells, and realizes cell autonomous regulation, thereby helping collagen regeneration and skin function reconstruction, and achieving anti-aging effects.
▍Bernard Mourieux, Chief Scientific Advisor and Chairman of the Academic Committee of Marubeni, Academician of the French Academy of Sciences, and former President of the French National Academy of Sciences
Because of this, recombinant collagen is gradually used in the field of skin care and has become a star ingredient in the anti-aging industry. However, there are still two difficulties in the research and application of recombinant collagen: how to ensure the high quality and stability of raw materials, and how to achieve large-scale mass production?
In fact, recombinant collagen has already entered the era of synthetic biology, and how to rely on genetic engineering technology to better transform chassis cells is an important direction for the future development of recombinant collagen. Pichia pastoris, as a second-generation yeast expression system, is widely used in protein preparation and industrial-scale production. The combination of the two has become an important breakthrough in the iteration of Marubeni's recombinant collagen technology.
Therefore, Marubeni's answer is to apply a new Pichia pastoris expression system with the blessing of synthetic biotechnology on the basis of retaining the classic double collagen sequence design.
"Pichia pastoris synthesis technology and application, so that recombinant collagen plugged into the wings of take-off, this step Marubeni has gone for more than 20 years. According to Lin Ying, co-chief scientist of Marubeni's recombinant collagen, professor and doctoral supervisor of South China University of Technology, and director of the Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering, the introduction of synthetic biology into Pichia pastoris research is like changing from a "black box" to a "white box", which can obtain more and more accurate preparation products, and also has a high level of recombinant collagen production capacity.
▍Lin Ying, Co-Chief Scientist of Marubeni Recombinant Collagen, Professor and Doctoral Supervisor of South China University of Technology, and Director of Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering
Under the collision of Pichia pastoris research and synthetic biotechnology, Marubeni's patented technology of "translation suspension", and "Marubeni's recombinant double collagen 2.0" made its debut at this forum. This not only represents a breakthrough research achievement for the industry, but also opens a new window for the research and application of recombinant collagen.
According to Xiong Sheng, chief scientist of Marubeni's recombinant collagen, the newly unveiled Marubeni recombinant double collagen 2.0 has the same degree of proline hydroxylation as natural collagen, and has formed a triple helix and collagen fiber precursor, which is more stable, more homologous, more active and more efficient than the 1.0 stage, and achieves all-round improvement in five aspects: structural activity, transdermal activity, anti-aging activity, soothing activity and moisturizing activity.
▍Marubeni Recombinant Collagen Chief Scientist Xiong Sheng
For example, third-party experiments showed that after 14 days of continuous use of Marubeni's recombinant double collagen 2.0 sample, the area of nasolabial folds, crow's feet, and under-eye lines was significantly reduced, and the skin elasticity, firmness, and radiance were significantly enhanced. In addition, Marubeni Recombinant Dual Collagen 2.0 can cause a rapid reduction in redness after 30 minutes, and after 14 days of use, the red areas on the face can be visibly reduced.
Recombinant Dual Collagen 2.0 is also one of the achievements of Marubeni's independent intellectual property system, which has applied for a total of 26 recombinant collagen-related patents, a full-type recombinant collagen yeast cell bank including 44 different polypeptide chains of 28 types of collagen, and more than 100 small molecule active collagen gene banks.
It can be said that Marubeni's research and development in the field of recombinant collagen has been at the forefront of the industry. As Sun Huaiqing, Chairman of the Board and CEO of Marubeni, said: "In terms of collagen anti-aging, Marubeni is once again far ahead!"
▍Sun Huaiqing, Chairman of the Board and CEO of Marubeni Co., Ltd
Three major advancements, comprehensive product iteration
Of course, no matter what kind of cutting-edge theoretical research, it ultimately needs to be implemented in the product in order to truly play the role of research and development. For a long time, Marubeni has always put the integration of production, education and research in the first place, therefore, at this forum, Marubeni launched the second-generation "Marubeni Collagen Small Golden Needle" with recombinant double collagen 2.0 as the core.
In fact, as early as 2021, Marubeni launched the first generation of "Marubeni Collagen Small Golden Needle". The product uses Marubeni's most cutting-edge patented human homologous chimeric recombinant double collagen, which can directly charge type I contour collagen and type III collagen to achieve a 10-day light wrinkle effect.
However, based on the advanced research and development of recombinant collagen in recent years, as well as a more complete insight into skin aging, Marubeni started from the systematic aging of collagen and the rigid characteristics of "collagen homeostasis", and matched a more systematic solution for the "Marubeni Collagen Golden Needle".
According to Chen Jiayang, deputy director of content marketing of Marubeni, the second-generation "Marubeni Collagen Little Golden Needle" has achieved three major functional advancements in the fields of collagen, anti-aging and repair. Among them, in terms of collagen, the second-generation "Marubeni Collagen Little Golden Needle" uses the latest Marubeni Double Collagen 2.0 mentioned above, on the basis of chimeric recombinant double collagen, using Pichia pastoris system, with C-pro buckle structure stable triple helix, which can achieve dual-channel transdermalization, directly participate in the assembly of human collagen fibers, and achieve a direct increase in efficacy from the core ingredients.
In terms of anti-aging advancement, in addition to Marubeni Double Collagen 2.0 as the foundation, the second-generation "Marubeni Collagen Little Golden Needle" also adds French helichrysum extract, which locks the collagen network with natural collagen molecules. At the same time, the new product also contains 3 star peptide complexes, including acetyl hexapeptide-8, snake-like peptide, and arginine/lysine polypeptide, which block the production of expression lines from 3 major targets.
The results of the third-party experiment showed that after 14 days of continuous use of the product, the nasolabial folds were reduced by 41.83%, the forehead wrinkles by 42.54%, the Sichuan wrinkles by 45.90%, the corners of the mouth by 33.66%, and the wrinkles at the corners of the eyes by 41.25%.
In terms of advanced repair, the second-generation "Marubeni Collagen Little Golden Needle" not only adds Marubeni's self-developed patented ingredient kapok extract, but also blends natural compound plant extract and ectoin, which can reduce the release of inflammatory factors and repair redness and soothe sensitiveness. Third-party experiments have shown that redness can be achieved after only 15 minutes of use, and after 7 days of use, skin scaling and red areas are visibly reduced.
In addition, at this forum, Marubeni also simultaneously released the Marubeni Xiaojin Needle Collagen Patch and Marubeni Collagen Elastic Mask Cream with Marubeni Double Collagen 2.0 as the core, from emergency relief to long-term care, to create a recombinant double collagen family, and provide users with a full range of anti-aging repair solutions.
Leading the formulation of industry standards
Marubeni enters a new era
When an enterprise has made considerable achievements in products and R&D, the next step is to look in a farther direction, that is, to build a healthier and more scientific industry standard with cutting-edge enterprises and institutions in the industry.
Tan Jianhua, a professor-level senior engineer of the National Cosmetics Quality Inspection and Testing Center and the Guangzhou Institute of Quality Supervision and Testing, mentioned that due to the lack of unified standards, the application of recombinant collagen in the field of cosmetics still has many uncontrollable safety risks, such as quality and safety, shoddy, opaque information, inconsistent product batches, etc., which urgently requires a unified national industry standard.
In fact, in the guidance of industry standardization, Marubeni has always been at the forefront. As early as the 2nd Recombinant Collagen Forum, Marubeni officially launched the standard formulation of recombinant collagen in five directions: skin care, medicine, food, cosmetic raw materials, and efficacy evaluation methods. This year, Marubeni's participation in the "General Requirements for Collagen Skin Care Products", "Oral Collagen Bioavailability Determination Method", "Medical Collagen Product Quality Requirements", "Recombinant Collagen Raw Material Efficacy Evaluation Method", and "Cosmetic Recombinant Collagen" five group standards were officially released, which is also the perfect answer sheet for the industry as a "leader".
This year, Marubeni once again launched a new round of standardization. At this forum, Marubeni, together with the China Biological Fermentation Industry Association and the National Cosmetics Quality Inspection and Testing Center (Guangzhou), launched the formulation of the national industry standard for "Recombinant Soluble Collagen".
Qingyan learned at the scene that the industry standard will define the terms and definitions of recombinant soluble collagen, safety requirements, and specify in detail its product classification, technical requirements, inspection rules, labeling, packaging, transportation and storage requirements, and corresponding experimental methods.
Tan Jianhua, Deputy Director of the Chemical Inspection Department of the National Cosmetics Quality Inspection and Testing Center (Guangzhou), commented: "The industry standard of "Recombinant Soluble Collagen" led by Marubeni has filled the vacuum of national standards and promoted the benign and sustainable development of the market, and firmly consolidated China's leading position in the world of recombinant collagen. ”
It can be said that the launch of industry standards not only means that recombinant soluble collagen will have standards to follow, but also is more conducive to the innovation and transformation of the industrial structure, as well as the benign and sustainable development of the market.
In addition, at this forum, Marubeni also put forward the "Recombinant Collagen High Quality Standard Initiative", which advocates that recombinant collagen should not only meet the requirements of "Recombinant Soluble Collagen", but also need to pass five verifications: collagen sequence, functional structure, transdermal absorption, human efficacy, and industrialization.
According to Guo Chaowan, deputy general manager of R&D of Marubeni Biologics, in terms of sequence, it is necessary to make it clear that the recombinant collagen is consistent with the sequence of human collagen; in terms of functional structure, it is necessary to ensure that the recombinant collagen has a protein higher order structure above the tertiary structure; in terms of transdermal absorption, it is necessary to ensure that the recombinant collagen can be well accepted by the skin; in terms of human efficacy certification, it is necessary to ensure that the recombinant collagen raw materials have a third-party human efficacy evaluation report and have real efficacy on the skin; in terms of industrialization, it is necessary to ensure that the recombinant collagen is prepared through a stable process and large-scale production, with stable quality and good quality control during the validity period。
▍Guo Chaowan, deputy general manager of R&D of Marubeni Biologics
Marubeni Biopharma would like to call on the whole industry to align with the five high-quality standards of recombinant collagen raw materials, standardize the production and application of recombinant collagen, and jointly promote the development of the recombinant collagen industry into a new era. Sun Huaiqing appealed at the scene.
Today, the Marubeni Recombinant Collagen Forum has entered its fourth session. As the research and application of Marubeni's recombinant collagen enters the 2.0 era, this is not only another milestone for Marubeni's deep cultivation in the field of anti-aging, but also means that Marubeni will come up with more new achievements and new products in the future to inject new momentum into the development of the industry.