On the mainland, one in every ten newborn babies is premature. Because their organs are not yet mature, they often have poor resistance to the outside world, are very prone to various complications, and the rate of disability and death is constantly rising. Among the various complications, "bronchopulmonary dysplasia (BPD)" is the word that premature families are most afraid to hear, because it represents too much pain.
The angels who arrived early are being tortured
Bronchopulmonary dysplasia is a chronic lung disease that causes persistent respiratory distress. Due to immature lung development. Premature babies can only be supported by mechanical ventilation with a bed. However, the ventilator is a double-edged sword, although it helps premature babies to breathe, but thus damage the baby's normal development of alveoli and microvessels, resulting in irreversible lung damage.
In the traditional treatment method, the doctor will release the drug through medical means, and control the time limit of use of the child's ventilator and pay attention to the supply of liquid nutrition, in order to achieve the purpose of protecting the child's lungs and inducing the child to develop a normal and complex alveolar structure. However, this does not allow the damaged alveoli to grow again, much less for weak children to gain the ability to resist other complications such as fungal sepsis [1].
How to open a breathing road and life path for premature children in medical treatment has become a big stone in the heart of every practitioner.
The doctor's tireless efforts have allowed families of premature babies to regain hope
In recent years, with the continuous development of cell science, cell therapy for neonatal diseases has become a hot topic in medical research.
In 2017, Dr. Won Soon Park and colleagues from Samsung Medical Center and the Samsung Institute of Biomedical Research in South Korea transplanted mesenchymal stem cells derived from human cord blood from the trachea into nine very preterm infants aged 24 to 26 weeks who were at higher risk of developing bronchopulmonary dysplasia in a Phase I clinical trial. In the end, the experimental results showed that the intratracheal injection of umbilical cord blood mesenchymal stem cells was safe and feasible for the treatment of BPD, and all 9 children survived smoothly. At the same time, studies have shown that systemic or endotracheal administration of cord blood mononuclear cells (CB-MNCs) is biologically active and regenerative in a variety of adult lung diseases [2].
Based on these two medical experiences, the Chinese the Bayi Children's Hospital of the Seventh Medical Center of the General Hospital of the People's Liberation Army of the Chinese People's Liberation Army, and after controlled treatment of BPD mice, the potential mechanism of umbilical cord blood mononuclear cells and umbilical cord mesenchymal stem cells for the treatment of BPD was further understood, and it was found that the transfusion of umbilical cord blood mononuclear cells had a prominent role in preventing alveolar simplification and pulmonary vascular loss, restoring lung respiratory function and regulating inflammation.
In clinical practice, cord blood really plays a strong role:
A baby of 25+ gestational age, who was diagnosed with severe BPD at birth, came to the world for four months but never evacuated the ventilator. After the infusion of cord blood, the child's airway hyperresponsiveness is alleviated, and the family finally does not have to panic for complications that may be sudden at any time; infants with a gestational age of 25 + w and a corrected gestational age of 36 weeks evacuate the invasive ventilator every other day after the infusion of umbilical cord blood, and change to a non-invasive ventilator to assist breathing, and the inhaled oxygen concentration drops from 40% to 20%. Now, the child has been successfully discharged from the hospital, and the word "premature birth" has left no trace in his life.
Medicine never stops. Although there have been cases confirming that cord blood has a significant effect on BPD, the Bayi Children's Hospital affiliated to the Seventh Medical Center of the General Hospital of the People's Liberation Army of the Chinese still plans to further carry out phase III clinical controlled studies of CB-MNC in the treatment of BPD premature infants, and follow up the children to the school age period in order to have a more comprehensive grasp of the prognosis effect of cord blood in the treatment of BPD.
The development of medicine has given the angels who arrive early the opportunity to live a normal life; and as the closest person to the child, the parents' decisions and choices during pregnancy are the key to the healthy birth of the child.
Focus on "preterm birth", starting with pregnancy
According to the British "Independent" newspaper, the number of premature babies around the world is increasing, especially in developed countries. Although fertility rates are decreasing, the proportion of premature babies remains high, and not only are children unable to have a normal life, but their families are also caught in increasing burdens and pressures [3].
Dr Lou Lou, an expert in obstetrics and gynecology at Run Run Run Shaw Hospital affiliated to Zhejiang University, said that although the birth rate of premature babies in the mainland is not as high as in developed countries, taking precautions is something that every family has to do [4].
So, how to plan ahead?
Doctors suggest that the majority of pregnant women and friends focus on the prevention of high-risk factors that cause preterm birth.
Pay attention to personal hygiene, if there is gynecological inflammation should be treated in time to avoid causing chorioamnionitis, which in turn causes premature rupture of amniotic fluid and causes premature birth.
Pay attention to sugar control during pregnancy, avoid excessive pressure in the amniotic cavity due to excessive amniotic fluid, stimulate the uterus to cause spontaneous contractions or premature rupture of membranes.
Pay attention to pregnancy discomfort such as cough and constipation, and avoid prolonged increased negative pressure leading to premature birth.
If you are pregnant with the help of scientific and technological means or have multiple preterm birth histories, you should seek medical attention in time and follow the doctor's instructions.
If the family's economic conditions permit, the umbilical cord blood can be stored during the mother's delivery, and a backup of the child's life can be saved to prevent the problem.
No family does not want the birth of a healthy baby, and no baby wants to be a burden on the family. While medical treatment breaks through the bottleneck of premature infant treatment, we must see the red power of umbilical cord blood, and together with it, we can support the baby with a sunny day that can breathe freely and grow up safely.
bibliography:
【1】Research Progress of Wang Lijuan Umbilical Cord Mesenchymal Stem Cells Journal of Inner Mongolia Medical College Vol. 32, No. 3, August 2010 (Advances in Medical Research)
【2】Bieback K，Kern S，Klüfiter H，etal.Critical Parameters forthe Isolation of Mesenchymal Stem Cells from Umbili-calCordBlood[J]. Stem Cells，2004：22(4):625-634
[3] Gao Jiejin, Wang Qi, Wang Dan, Qian Yan Clinical Analysis of Bronchopulmonary Dysplasia in Preterm Infants Chinese Journal of Eugenics and Genetics, Vol. 18, No. 12, 2010
[4] Why are there more and more premature babies in developed countries? - Parenting Network (ci123.com)
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