Zhang Wenhong: A record high of imported cases are preparing clinical trials for domestic covid-19 oral drugs

The Omiljunn variant is having a significant impact on the development of the global outbreak. From 0 to 24:00 on January 12, there were 124 new indigenous cases in China. There were 9 new suspected cases, all imported from abroad, all in Shanghai.

On the morning of January 13, Zhang Wenhong, director of the Department of Infectious Diseases of Huashan Hospital, posted on the official WeChat of Huashan Infection that the recent international community is in a very high-risk period of new crown. The pressure on imported outbreaks is enormous.

"During this period, the epidemic prevention troops in various places can be said to be 'walking on thin ice and waiting for the pillow'." Zhang Wenhong wrote, "Once there are local infected people, the epidemic prevention force does not stay overnight, and all close contacts and sub-close contacts will be controlled at the first time, and through meticulous and rapid work, the virus will be controlled." ”

On the morning of January 13, the new crown treatment team of Zhang Wenhong's hospital office once again sorted out all inpatient cases. Zhang Wenhong revealed that the number of imported infected people in the new crown ward of Shanghai Public Health Clinical Center has reached a record high.

On 11 January, a case of imported asymptomatic infection in Shanghai was concerned about the abnormal nucleic acid test results on the 7th day of nucleic acid testing during the 7-day health monitoring period after the expiration of the isolation period. In this regard, Zhang Wenhong believes that the situation during the monitoring period of such inbound personnel can be handled according to the norm, and there is no need to over-interpret it.

But he reminded: "Relevant personnel must conscientiously fulfill this health monitoring period in the future, make themselves safer, and make the people around them safer." ”

Recently, the characteristics of the Aomi Kerong mutant strain have also attracted great attention from the scientific community. Zhang Wenhong said that after comparing the clinical characteristics of the Olmi kerong mutant strain and the previous Delta variant, it was found that compared with the Delta, the Omicron spread faster and more covertly, but still has a lethality that cannot be ignored.

Zhang Wenhong's team also discussed with the scientific research team the recent progress of protective research on Aomi Kerong after vaccine enhancement injection, and prepared for the upcoming clinical research of a new class of oral anti-COVID-19 oral drugs developed and innovated by China itself.

Zhang Wenhong believes that vaccines and drugs will be the core scientific and technological support for us to survive the pandemic and return to normal life in the future. "China's scientific and technological forces, like the epidemic prevention forces, have been working tirelessly to smooth the global epidemic and save our people from the fear of infectious diseases." He wrote.

The team also had an in-depth discussion on WHO's newly summarized Recommendations for Prevention and Control of Omikeron. Based on the current global evidence, WHO has given new recommendations for prevention and control, which are of great reference for understanding the differences in the strategies of international countries to fight the epidemic.

According to a large study of 70,000 confirmed COVID-19 cases conducted by researchers at the University of California, Berkeley, Kaiser Permanente, and the Centers for Disease Control and Prevention (CDC), the risk of hospitalization and death caused by Omiqueron is greatly reduced compared to Delta, and the level of immunity in the population will also increase.

The study data suggest that people infected with Omeikron are half as likely to be hospitalized as delta cases; the risk of entering the intensive care unit is reduced by about 75 percent and the risk of death is reduced by more than 90 percent. Of the more than 52,000 cases infected with Omicron, no one needed life support, while of the 17,000 cases infected with Delta, 11 needed life support.

In addition, the median hospital stay for infection with Aomi Kerong was 1.5 days, while the median length of stay for infection with Delta was close to 5 days.

CDC Director Rochelle Walensky cited the study in detail at a news conference on Wednesday, interpreting: "Omi kerong is not as serious as Delta in nature, but its high contagiousness has led to a large number of hospitalizations, putting a strained care system that has been strained for two years." ”

The U.S. currently reports an average of 750,000 COVID-19 cases per day, with about 1,600 deaths per day. The number of COVID-19 hospitalizations has exceeded 150,000, a record high.

In France, the anti-epidemic situation is equally grim. According to a new study released wednesday by the Institut Pasteur in France, the outbreak in France has not yet peaked. In recent days, the number of new confirmed cases in France has continued to exceed 300,000. The Pasteur Institute researchers predict that the peak of infection is expected to occur in mid-January, and in any case, a peak in admissions is expected to occur in the second half of January, with the greatest impact on bed occupancy rates from late January to February.

In this regard, Zhang Wenhong said: "The Aomi Kerong mutant strain has replaced Delta, the old overlord of the new crown world, in evolution. The international prevention and control situation is in the midst of great uncertainty and rapid transformation of the prevention and control model. ”

Based on the information recently released by WHO, Zhang Wenhong judged that the global risk caused by the current new crown variant is still very high. Despite indications of lower severity, Ami kerong is spreading more quickly in the community than Indah, leading to a surge in hospitalizations, with serious consequences and burdens on the health system and other relevant sectors. Humanity's struggle with Aomi Kerong is still in its most difficult moment.

But he still said there were signs that things were also moving in the direction of humanity. "China's best strategy at this time is to maintain strategic determination and patience, maintain the strategy of strengthening vaccination and public health prevention and control strategies, exchange time for space, and finally at the most appropriate time node, successfully pass the pandemic period with a very low COVID-19 mortality rate, and gradually normalize life." Zhang Wenhong wrote.