With the continuous development of IVF technology, on the basis of the first generation and the second generation, there has been a third generation of IVF technology, and Hengjian Overseas will introduce its price and process in detail.
First, how much does it cost to have a third generation of IVF
A single cycle of medical costs generally need about 9-11 million yuan (pre-examination, conditioning, induction, matching, PGS/PGD screening, etc.), if the woman's follicles are relatively small, it may be necessary to carry out 2-3 times of stimulation, the cost is higher, and it is possible to double.
Second, the advantages of third-generation IVF
Although the third generation of IVF is a little expensive, but the technology is also much more advanced, called preimplantation genetic diagnosis, mainly for genetic patients with abnormal chromosomes or disease-causing genes. It is carried out on the basis of the first and second generations, and the third generation of IVF selects embryos with no chromosomal abnormalities or abnormal genes for intrauterine transfer, which blocks the genetic disease to future generations, so the cost is also higher.
Third, the process of third-generation IVF
1. Comprehensive inspection
Before the third-generation IVF transplant, both husband and wife need to do a comprehensive examination, such as routine blood draw to check for hepatitis B, syphilis, HIV, hepatitis C, hepatitis A, etc., through these tests, you can determine whether there are conditions for the third generation of IVF.
2. Formulate a detailed plan
Through relevant genetic counseling, medical history review, etc., a clear plan for third-generation IVF technology should be developed, because the program is different for different individuals.
3. Promote ovulation
The woman needs to be super-ovulatory injection, after 8-12 days of injection, the egg needs to be retrieved under the guidance of the B ultrasound, and then the man's semen is retained on the same day, so that the sperm and egg can be naturally fertilized in combination (the first generation) outside the body, and the sperm can also be directly injected into the woman's egg (second generation).
4. Culture embryos
Embryo culture needs to be carried out in vitro, generally to the 5th or 6th day of the blastocyst, the specific process is to select embryonic trophoblast ectoderm cells for relevant testing, to determine whether the embryonic chromosomes (23 pairs of chromosomes screened for PGS) are normal, whether to carry the pathogenic gene (genetic disease gene point is PGD). By screening the trophoblast layer, embryos detected as normal can be transferred, and abnormal abandonment. In the clinic, it is also possible that all embryos carry genetic disease genes/chromosomal abnormalities and cannot be transplanted, in which case they can continue to be matched and screened, or they can give up their sperm eggs to find someone to sperm or donor eggs.
Fourth, the third generation of IVF is suitable for the population
We must have a clear understanding of the third generation of IVF, not that it is more advanced than the first and second generations, but for different groups of people, take different methods:
1. The third generation is mainly for patients with single-gene genetic diseases who have identified the cause in advance, common such as thalassemia, albinism, hemophilia, etc., which can reduce the birth of children carrying pathogenic genes.
2. Patients with recurrent miscarriage due to Roche translocation and mutual translocation of chromosomes need to be tested for genetics before embryo transfer.
3. There are hereditary diseases that are transmitted from male to female (hemophilia, hypertrophic progressive muscular dystrophy, fava bean disease, red-green blindness, congenital gamma-no-gamlinosis, hereditary deafness, hereditary optic nerve atrophy, etc.) or female to male (type II diabetes, breast cancer, obesity, Reiter's disease, early-onset infant epileptic encephalopathy type 9, etc.), and the population needs to select gender.
V. Precautions for the third generation of IVF
1. The third generation of IVF takes about 50 days, of which chromosomal screening takes about 20 working days. Some people ask why some institutions are screening so fast? The results came out in a few days. That's not screening 23 pairs of chromosomes, it's the FISH technique of screening 5 pairs of chromosomes.
2. If it is clear that one of the husband and wife has a genetic disease or chromosomal abnormality, it is necessary to communicate with the doctor in detail to see whether it is a disease that is transmitted from man to woman or from woman to man. If not, it is possible that all embryos will be carried, there are no normal embryos to transfer, the money is spent, and there are no embryos to transfer.
3) Not everyone can do a third-generation IVF.