Qianjiang Evening News Hourly News Reporter Zhang Bingqing Correspondent Sun Meiyan
How to lift the "genetic curse" of the family with genetic diseases? Can cervical cancer, one of the most common cancers in women, be eliminated? In the face of these problems, the Obstetrics and Gynecology Hospital affiliated to Zhejiang University School of Medicine continues to lead the national major projects, and strives to implement the requirements of building a "medical peak" and a "life and health science and technology innovation highland", facing difficulties and overcoming difficulties.
On the long road of protecting women's reproductive health, the scientific research and clinical practice of Zhejiang University Women's Hospital go hand in hand. At present, the Zhejiang Provincial Obstetrics and Gynecology Discipline Innovation and Transformation Alliance led by Zhejiang University Women's Hospital has absorbed 29 top three hospitals and 12 medical science and technology innovation enterprises in the province. Qin Jiale, director of the Scientific Research Office of Zhejiang University Women's Hospital, said that since the establishment of the alliance, it has held two sessions of Zhejiang Obstetrics and Gynecology Innovation and Transformation Competition, and more than 30 medical and enterprise docking discussions have been held, and a number of scientific and technological achievements have been promoted to enter clinical trial verification and product production.
If you are born, you must also be born well
The path of fertility assistance for patients with reproductive disorders is more precise
Zhejiang University Women's Hospital is at the forefront of the world in terms of the causes, pathogenesis and clinical application of reproductive endocrine diseases, leading various research projects such as "863", "973", "Twelfth Five-Year Plan" and "Thirteenth Five-Year Plan" national major/key research and development projects, and has mature pre-implantation genetic diagnosis technology to avoid the risk of repeated abortion, eliminate tumor (genetic) risk, block the risk of rare genetic disease offspring, and create a "first case" in Zhejiang Province and even the whole country, and with the development of assisted reproductive technology, The goal of fertility technology has also gradually changed from "born" to "born well". He led the national "13th Five-Year Plan" key special research and development plan of "Research on the Occurrence Mechanism and Clinical Intervention of Ovulation Abnormalities" and "Research on the Genetic Safety of Assisted Reproduction".
Image source: Visual China
Academician Huang Hefeng accurately blocked the birth of children with a variety of rare genetic diseases through PGT technology, blocked the "genetic curse" for many families with genetic diseases, put forward the theory of "gamete-derived diseases" for the first time in the world, and conducted pioneering research on the intergenerational and intergenerational genetic/epigenetic mechanisms of sperm/ovidogenic diseases, and won a series of major awards.
Professor Zhu Yimin led the team to establish the first ART offspring health follow-up center in China, accumulated a cohort of nearly 7,000 cases of physical and mental development of ART births, and discovered that parental factors and in vivo and in vitro interventions on germ cells affect the IQ of ART births and the occurrence of metabolic diseases. In order to block the occurrence of birth defects, Professor Jin Fan's team has established a safety assessment and genetic defect blocking system for assisted reproduction offspring.
Cervical cancer is expected to be eliminated
Zhejiang experts are working towards this goal
In May 2018, the WHO Director-General called on all countries to take action: eliminate cervical cancer globally by 2030. In January 2019, the 13th meeting of the 144th Executive Committee of the WHO considered the decision: Draft Global Strategy to Accelerate the Elimination of Cervical Cancer (2010-2030). The World Health Organization currently advocates countries: the coverage rate of HPV vaccine for girls under 15 years of age should reach more than 90%, the coverage rate of adult women aged 35 to 45 with effective cervical cancer screening should reach more than 70%, and at least 90% of women with positive screening should receive reasonable treatment and reasonable management.
According to who statistics in 2020, there are 600,000 new cases of cervical cancer and about 340,000 deaths worldwide. Among them, the new cases of cervical cancer in China are close to 110,000, and the number of deaths is nearly 60,000.
As the national team and main force in the field of obstetrics and gynecology, Zhejiang University Women's Hospital actively focuses on the global strategy of accelerating the elimination of cervical cancer proposed by the World Health Organization, the national 2030 health strategy and the health Zhejiang strategy, actively undertakes the major national research tasks in the field of cervical cancer prevention and treatment, and strives to solve the field of card neck technology.
During the 13th Five-Year Plan period, Professor Lu Weiguo's team led the national key research and development project of "Research on New Technologies and Protocols for Cervical Cancer Screening and Intervention", established Chinese cervical cancer screening database, displayed the epidemiological data of HPV infection and subtype distribution in different regions of China, developed a high-throughput miRNA detection kit for cervical exfoliation cells based on RNA molecular markers, and completed large-scale population verification; and compared the kit with the COBAS kit, a first-line and primary screening tool in the United States. Prove its screening efficacy and effectively promote the localization process of HPV kits. The relevant achievements have won 1 first prize of science and technology progress of the Ministry of Education and 2 national invention patents, which have great scientific value for formulating cervical lesion screening strategies in line with China's national conditions.
In the first year of the 14th Five-Year Plan, Professor Wang Hui's team continued to conduct in-depth research on the basis of existing cervical cancer research in hospitals, and led the national key research and development program project "Research on accurate screening and prevention of cervical lesions", aiming to develop a new technology for the accurate screening of original cervical lesions based on the integration of high-risk HPV and establish a new strategy for precise targeted intervention for the malignant transformation of persistent infection of high-risk HPV, forming a comprehensive prevention and treatment guideline for cervical lesions based on Chinese research data.
The series of cervical cancer research carried out by Zhejiang University Women's Hospital provides an important basis for building a comprehensive prevention and control model for eliminating cervical cancer in line with China's national conditions, provides a direction for leading the development of bio-high-tech industry in the field of cervical cancer prevention in China, will promote the transformation of China's cervical cancer prevention and treatment technology from and running to the world's leading position, promote the significant reduction of the incidence and mortality rate of cervical cancer in China, further improve the quality of life of sick women, and effectively reduce the huge medical cost burden invested by the state in the prevention and treatment of cervical cancer.
Persistent disease of pelvic floor muscle relaxation in women with vaginal birth
New electrophysiological detection to crack
Every woman who has given birth, especially a vaginal birth, sooner or later will almost encounter a problem that is difficult to talk about - pelvic floor muscle relaxation, usually manifested as leakage of urine, urinary incontinence, uterine prolapse, etc., and even severe uterus will suddenly fall when going to the toilet.
At present, the number of patients with pelvic floor dysfunction diseases worldwide exceeds 30 million per year, which seriously affects women's health and quality of life. The team of chief physician Xie Zhenwei of Zhejiang University Women's Hospital has been committed to pelvic floor treatment research for many years to solve their unspeakable secrets.
The pelvic floor muscles of women are the muscle groups that enclose the pelvic floor, which is like a hammock, which encloses the organs such as the urethra, bladder, vagina, uterus, and rectum, so that they each belong to their place, perform their duties, and perform their functions normally. If the pelvic floor muscle is injured and the net is "loose", it may not be able to hold these organs, and leakage of urine, prolapse, etc. will occur.
Xie Zhenwei's team and Dong Shurong's team of the Institute of Intelligent Sensing of Zhejiang University jointly pioneered the design concept of "accurate collection of pelvic floor surface emography", through the combination of medical industry and information, designed an extendable electronic and inflatable device, which can provide a stable contact interface and maintain the accuracy of electrophysiological signals, solve the existing pelvic floor muscle bioelectric signal acquisition system Stability and accuracy are relatively low, can not achieve accurate diagnosis and treatment of the problem, for the early accurate diagnosis and treatment of female pelvic floor dysfunction diseases to lay a technical foundation.
While scientific research achievements have made breakthroughs, clinical transformation is also gradually promoting. At the inauguration ceremony of the Zhejiang Obstetrics and Gynecology Discipline Innovation and Transformation Alliance, the artificial intelligence pelvic floor disease diagnosis and treatment system (Bon Yikang) was successfully transformed and is docking with enterprises, taking a key step for future clinical application.
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