In the past, the well-known "three high" diseases were hypertension, high blood lipids and diabetes, which are the three most common chronic diseases in China.
However, in recent years, with the growth of China's economic level, diet and living habits and other aspects of the impact, there is a disease is quietly developing, becoming the fourth highest after the three high diseases, it is: hyperuricemia!
Relevant data surveys show that there are currently about 120 million patients with hyperuricemia in China, accounting for about 9% of the total population. The disease seems to be just a metabolic disorder of blood uric acid levels, but it will cause damage to multiple organs and tissues of the body, which is the basis for inducing gout;
Not only that, because uric acid needs to be metabolized through the kidneys, long-term blood uric acid index disorders can increase the metabolic burden of the kidneys and induce chronic kidney disease. Relevant data show that in patients with hyperuricemia, the risk of reduced renal function has reached about 21%, and the risk of death due to chronic kidney disease is even as high as 68%!
Hyperuricemia not only causes kidney damage and gout, it can also cause the following serious harms:
1. Diabetes
Relevant data show that the risk of diabetes in patients with hyperuricemia is more than 2 times higher than that of other healthy people, and both are metabolic diseases.
The reason why high uric acid may be combined with diabetes mellitus is because the continuously elevated blood uric acid level is easy to damage the function of islet cells, resulting in insulin secretion disorders, glucose can not be normal metabolic function, and gradually develop into cellular insulin resistance, and eventually diabetes mellitus appears;
2. High blood lipids
Studies have shown that hyperuricemia is closely associated with various metabolic syndromes, and in addition to the diabetes mellitus mentioned above, it can also cause disorders of blood lipid metabolism.
Patients with hyperuricemia have triglycerides and LDL cholesterol levels significantly exceed the standard, lipid metabolism and uric acid metabolism can interact with each other, uric acid will reduce the activity of lipoproteinase, resulting in lipid metabolism disorders, hyperlipidemia therefore attack. Not only that, hyperuric acid and hyperlipidemia are independent risk factors for inducing atherosclerosis;
3. Hypertension
Continuously elevated blood uric acid levels are easy to affect endocrine, activate the renin-angiotensin system, promote the secretion of a large number of epinephrine and catecholamines, and at the same time reduce the synthesis of nitric oxide in vascular endothelial cells, resulting in abnormal proliferation of vascular smooth muscle, causing vascular remodeling mechanism, and hypertension.
Once hypertension appears, the patient's glomerular arteries may gradually harden, affecting blood uric acid metabolism and eventually forming a vicious circle;
4. Atherosclerosis
Soluble uric acid causes irreversible damage to the endothelial cells of the blood vessels, and the higher the level of blood uric acid, the greater the damage to the endothelial cells. Not only that, the uric acid crystals precipitated from uric acid will gradually deposit on the walls of blood vessels, inducing vasculitis and further damaging the endothelium of the patient's blood vessels.
At the same time, hyperuricemia can also interact with the three high diseases, promote the formation of atherosclerosis, and lay major hidden dangers for cardiovascular and cerebrovascular diseases.
Written in the end: Hyperuricemia seems to be a metabolic disease, but it will cause damage to multiple systems, organs and tissues throughout the body, and even become a murderer who induces cardiovascular and cerebrovascular diseases and kidney failure. Therefore, as long as the diagnosis of hyperuricemia is confirmed, it should actively cooperate with the doctor for treatment, which includes two major aspects of life and diet adjustment, medication and so on.